Seminars in Nephrology
Volume 24, Issue 2 , Pages 115-119 , March 2004

AT1 receptor heterodimers and angiotensin II responsiveness in preeclampsia

  • Ursula Quitterer

      Affiliations

    • Institut für Pharmakologie, Versbacher Straße 9, Würzburg, D-97078, Germany
    • Corresponding Author InformationAddress reprint requests to Ursula Quitterer, PhD, Institut für Pharmakologie und Toxikologie, Versbacher Straße 9, D-97078 Würzburg, Germany
    • ,
  • Heinz Lother

      Affiliations

    • Heinrich-Pette-Institut, Martinistrasse 52, Hamburg, D-20251, Germany
    • ,
  • Said Abdalla

      Affiliations

    • Medical Research Center (MRC), Ain Shams University Hospital, Cairo, Egypt

References 

  1. Lain KY, Roberts JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002;287:3183–3186
  2. Abdul-Karim R, Assali NS. Pressor response to angiotonin in pregnant and nonpregnant women. Am J Obstet Gynecol. 1961;82:246–251
  3. Talledo OE, Chesley LC, Zuspan FP. Renin-angiotensin system in normal and toxemic pregnancies III. Differential sensitivity to angiotensin II and norepinephrine in toxemia of pregnancy. Am J Obstet Gynecol. 1968;100:218–221
  4. Aalkjaer C, Danielsen H, Johannesen P, et al.  Abnormal vascular function and morphology in preeclampsia (A study of isolated resistance vessels). Clin Sci. 1985;69:477–482
  5. Belfort MA, Saade GR, Suresh M, et al.  Effects of selected vasoconstrictor agonists on isolated omental artery from premenopausal nonpregnant women and from normal and preeclamptic pregnant women. Am J Obstet Gynecol. 1996;174:687–693
  6. Vedernikov YP, Belfort MA, Saade GR, et al.  Pre-eclampsia does not alter the response to endothelin-1 in human omental artery. J Cardiovasc Pharmacol. 1995;26:S233–S235
  7. Nakamura T, Ito M, Matsui K, et al.  Significance of angiotensin sensitivity test for prediction of pregnancy-induced hypertension. Obstet Gynecol. 1986;67:388–394
  8. Dekker GA, Makovitz JW, Wallenburg HC. Prediction of pregnancy-induced hypertensive disorders by angiotensin II sensitivity and supine pressor test. Br J Obstet Gynecol. 1990;97:817–821
  9. Oeney T, Kaulhausen H. The value of the angiotensin sensitivity test in the early diagnosis of hypertensive disorders in pregnancy. Am J Obstet Gynecol. 1982;142:17–20
  10. Haller H, Oeney T, Hauck U, et al.  Increased intracellular free calcium and sensitivity to angiotensin II in platelets of preeclamptic women. Am J Hypertens. 1989;2:238–243
  11. Langer B, Grima M, Coquard C, et al.  Plasma active renin, angiotensin I, and angiotensin II during pregnancy and in preeclampsia. Obstet Gynecol. 1998;91:196–202
  12. Brown MA, Reiter L, Rodger A, et al.  Impaired renin stimulation in pre-eclampsia. Clin Sci. 1994;86:575–581
  13. Mizutani S, Taira H, Kurauchi O, et al.  Angiotensin converting enzyme activity in normal pregnancy and pregnancy-induced hypertension. In:  Suzuki M,  Furuhashi N editor. Perinatal Care and Gestosis. Amsterdam: Elsevier; 1986;p. 385–388
  14. Ito M, Itakura A, Ohno Y, et al.  Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia. J Clin Endocrinol Metab. 2002;87:1871–1878
  15. Hanssens M, Keirse MJ, Spitz B, et al.  Angiotensin II levels in hypertensive and normotensive pregnancies. Br J Obstet Gynaecol. 1991;98:155–161
  16. Gordon RD, Symonds EM, Wilmshurst EG, et al.  Plasma renin activity, plasma angiotensin and plasma and urinary electrolytes in normal and toxaemic pregnancy, including a prospective study. Clin Sci. 1973;45:115–127
  17. Weir RJ, Brown JJ, Fraser R, et al.  Plasma renin, renin substrate, angiotensin II, and aldosterone in hypertensive disease of pregnancy. Lancet. 1973;1:291–294
  18. Masse J, Forest JC, Moutquin JM, et al.  A prospective longitudinal study of platelet angiotensin II receptors for the prediction of preeclampsia. Clin Biochem. 1998;31:251–255
  19. Pouliot L, Forest JC, Moutquin JM, et al.  Platelet angiotensin II binding sites and early detection of preeclampsia. Obstet Gynecol. 1998;91:591–595
  20. O’Brien PM, Walker TJ, Singh PK, et al.  Failure of platelet angiotensin II binding to predict pregnancy-induced hypertension. Obstet Gynecol. 1999;93:203–206
  21. Devi LA. G-protein-coupled receptor dimers in the lime light. Trends Pharmacol Sci. 2000;21:324–326
  22. Bouvier M. Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci. 2001;2:274–286
  23. AbdAlla S, Lother H, Quitterer U. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature. 2000;407:94–98
  24. AbdAlla S, Lother H, El Massiery A, et al.  Increased AT1 receptor heterodiemrs in preeclampsia mediate enhanced angiotensin II responsiveness. Nat Med. 2001;7:1003–1009
  25. Tschope C, Heringer-Walther S, Koch M, et al.  Myocardial bradykinin B2 receptor expression at different time points after induction of myocardial infarction. J Hypertens. 2000;18:223–238
  26. Haddad EB, Fox AJ, Rousell J, et al.  Post-transcriptional regulation of bradykinin B1 and B2 receptor gene expression in human lung fibroblasts by tumor necrosis factor-alpha (Modulation by dexamethasone). Mol Pharmacol. 2000;57:1123–1131
  27. Pesquero JB, Lindsey CJ, Paiva AC, et al.  Transcriptional regulatory elements in the rat bradykinin B2 receptor gene. Immunopharmacology. 1996;33:36–41
  28. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med. 1999;222:222–235
  29. Sullivan JM, Traynelis SF, Chen HS, et al.  Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron. 1994;13:929–936
  30. Akoev VR, Matveev AV, Belyaeva TV, et al.  The effect of oxidative stress on structural transitions of human erythrocyte ghost membranes. Biochim Biophys Acta. 1998;1371:284–294
  31. Bellomo G, Thor H, Orrenius S. Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes. J Biol Chem. 1987;262:1530–1534
  32. Reid JL. Vascular reactivity, adrenergic mechanisms, and arteriolar resistance in hypertension. J Cardiovasc Pharmacol. 1988;12:S114–S120
  33. Reid JL, Donnelly R, Meredith PA, et al.  Pressor responsiveness in essential hypertension and the effects of treatment with an alpha blocker, calcium antagonist or ACE inhibitor. Clin Exp Hypertens. 1989;11:247–256
  34. Touyz RM, Schiffrin EL. Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients (Role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways). J Hypertens. 2001;19:1245–1254
  35. Duggan J, Kilfeather S, O’Brien E, et al.  Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density. Am J Hypertens. 1992;5:687–693
  36. Ding YA, Kenyon CJ, Semple PF. Regulation of platelet receptors for angiotensin II in man. J Hypertens. 1985;3:209–212
  37. Roberts J. Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16:5–15
  38. Zizek B, Poredos P, Videcnik V. Endothelial dysfunction in hypertensive patients and in normotensive offspring of subjects with essential hypertension. Heart. 2001;85:215–217
  39. Sattar N, Greer IA. Pregnancy complications and maternal cardiovascular risk (Opportunities for intervention and screening?). BMJ. 2002;325:157–160
  40. Stamler J, Stamler R, Neaton JD. Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med. 1993;153:598–615
  41. Millar JG, Campbell SK, Albano JD, et al.  Early prediction of pre-eclcampsia by measurement of kallikrein and creatinine on a random urine sample. Br J Obstet Gynaecol. 1996;103:421–426
  42. Gainer JV, Nadeau JH, Ryder D, et al.  Increased sensitivity to bradykinin among African Americans. J Allergy Clin Immunol. 1996;98:283–287
  43. Drayer JI, Weber MA, Laragh JH, et al.  Renin subgroups in essential hypertension. Clin Exp Hypertens. 1982;4:1817–1834
  44. Schobel HP, Fischer T, Heuszer K, et al.  Preeclampsia—A state of sympathetic overactivity. N Engl J Med. 1996;335:1480–1485
  45. Mancia G, Grassi G, Giannattasio C, et al.  Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension. 1999;34:724–728
  46. Palczewski K, Kumasaka T, Hori T, et al.  Crystal structure of rhodopsin (A G protein-coupled receptor). Science. 2000;289:739–745
  47. Quitterer U, Zaki E, AbdAlla S. Investigation of the extracellular accessibility of the connecting loop between membrane domains I and II of the bradykinin B2 receptor. J Biol Chem. 1999;274:14773–14778
  48. Fortiadis D, Liang Y, Filipek S, et al.  Rhodopsin dimers in native disc membranes. Nature. 2003;421:127–128

PII: S0270-9295(03)00197-9

doi: 10.1016/j.semnephrol.2003.11.007

Seminars in Nephrology
Volume 24, Issue 2 , Pages 115-119 , March 2004

Article Tools

* Image Usage & Resolution