Seminars in Nephrology
Volume 24, Issue 2 , Pages 93-100, March 2004

AT1 and AT2 receptor in the kidney: role in health and disease☆

  • Helmy M Siragy

      Affiliations

    • Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
    • Corresponding Author InformationAddress reprint requests to Helmy M. Siragy, MD, FACP, FAHA, Professor of Medicine and Endocrinology, University of Virginia Health System, P.O. Box 801409, Charlottesville, VA 22908 USA

Abstract 

The renin angiotensin system plays an important role in the control of body fluid and electrolyte homeostasis and blood pressure regulation. Angiotensin II is the most effector hormone of this system and functions mainly through stimulation of its subtype receptors, namely, the AT1 and AT2 receptors. Most of the known physiological and pathologic effects of angiotensin II are mediated through stimulation of the AT1 receptor. The knowledge about the involvement of the AT2 receptor in physiological and pathologic processes is still evolving. In the kidney, both the AT1 and AT2 receptors contribute to the regulation of renal hemodynamic and tubular functions. Also, these receptors regulate renal cellular growth and matrix formation. However, AT2 receptor possesses functions that counteract the effects of the AT1 receptor. The balance between the AT1 and AT2 receptors can determine the renal status in health and disease.

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☆ Supported in part by grants HL-57503 and DK-61400 to Helmy M. Siragy, MD, from the National Institutes of Health. Dr. Siragy was the recipient of the Research Career Development Award K04-HL-03006 from the National Institutes of Health.

PII: S0270-9295(03)00199-2

doi:10.1016/j.semnephrol.2003.11.009

Seminars in Nephrology
Volume 24, Issue 2 , Pages 93-100, March 2004

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