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Seminars in Nephrology
Volume 24, Issue 4
, Pages 333-344
, July 2004
Role of nitric oxide in diabetic nephropathy
References
- . Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage. J Clin Invest. 1992;90:278–281
-
L-arginine may mediate the therapeutic effects of low protein diets.
Proc Natl Acad Sci U S A. 1995;9:4552–4556
- . How does hyperglycemia predispose to diabetic nephropathy?. QJM. 1997;90:493
- Inhibition of nitric oxide synthase activity by early and advanced glycation end products in cultured rabbit proximal tubular epithelial cells. Biochim Biophys Acta. 2000;1502:481–494
- Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest. 2001;108:1341–1348
- . Impaired nitric oxide release by glomeruli from diabetic rats. Metabolism. 1995;44:695–698
- . Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of cholinergic response. J Clin Invest. 1994;93:311–320
- Diabetes-induced endothelial dysfunction in streptozotocin-treated rats (Role of prostaglandin endoperoxides and free radicals). J Am Soc Nephrol. 1993;4:1327–1336
- . The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes. Kidney Int. 2001;59:1859–1864
- . Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus. J Am Soc Nephrol. 1995;5:1559–1566
- . High glucose inhibits nitric oxide production in cultured rat mesangial cells. J Am Soc Nephrol. 1997;8:1276–1282
-
.
Tetrahydrobiopterin reverses the inhibition of nitric oxide by high glucose in cultured murine mesangial cells.
Am J Physiol. 2001;281:F179–F188
-
Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels (Possible mediation via protein kinase C).
Biochem Biophys Res Commun. 1995;6:80–88
- High glucose increases inducible NO production in cultured rat mesangial cells. Possible role in fibronectin production. Nephron. 2002;90:78–85
-
Mechanisms underlying endothelial dysfunction in diabetes mellitus.
Circ Res. 2001;88:E14–E22
-
Glucose scavenging of nitric oxide.
Am J Physiol. 2001;280:F480–F486
-
High glucose enhances growth factor-stimulated nitric oxide production by cultured rat mesangial cells.
Res Commun Mol Pathol Pharmocol. 1998;100:213–225
- Effect of vascular endothelial growth factor on nitric oxide production by cultured rat mesangial cells. Biochem Biophys Res Commun. 1998;245:443–446
-
Effect of D’glucose on nitric oxide release from glomerular endothelial cells.
Diabetes Metab Rev. 2001;17:217–222
- Nonenzymatically glycated albumin (Amadori adducts) enhances nitric oxide synthase activity and gene expression in endothelial cells. Kidney Int. 1997;51:27–35
- Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy. Diabetologia. 1998;41:1426–1434
- . Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metab. 2001;27:535–542
-
Regulation of eNOS expression by albumin derived advanced glycation end-products.
Circ Res. 2000;86:E50–E54
-
Workshop: Endothelial cell dysfunction leading to diabetic nephropathy: Focus on nitric oxide.
Hypertension. 2001;37:744–748
- Constitutive NOS expression in retinalvascular endothelial cells is suppressed by high glucose and advanced glycation end-products. Diabetes. 1998;47:945–952
- . Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest. 1991;87:432–438
- . Advanced glycosylation end products block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus. J Clin Invest. 1992;90:1110–1115
-
.
AGEs induce oxidative stress and activate protein kinase C-beta(II) in neonatal mesangial cells.
Am J Physiol. 2000;278:F676–F683
-
Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats.
Kidney Int. 1997;52(suppl 60):S23–S27
- Diabetes-induced microvascular dysfunction in the hydronephrotic kidney (Role of nitric oxide). Kidney Int. 2001;60:202–210
- Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy. J Am Soc Nephrol. 2000;11:71–79
- Nitric oxide synthesis and oxidative stress in the renal cortex of rats with diabetes mellitus. J Am Soc Nephrol. 2001;12:1630–1639
- Augmentation of diabetes-associated renal hyperfiltration and nitric oxide production by pregnancy in rats. J Endocrinol. 1999;161:15–23
- Renal nitric oxide production during the early phase of experimental diabetes mellitus. Kidney Int. 2000;58:740–747
- Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci U S A. 1992;89:11993–11997
- Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of 1diabetic nephropathy (Aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli). Diabetologia. 1999;42:878–886
- . An analysis of renal nitric oxide contribution to hyperfiltration in diabetic rats. J Lab Clin Med. 2001;137:107–114
- Effects of systemic inhibition of neuronal nitric oxide synthase in diabetic rats. Hypertension. 2000;34:655–661
-
Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes.
Am J Physiol. 2000;279:F573–F583
- Inhibition of neuronal nitric oxide synthase ameliorates renal hyperfiltration in streptozotocin-induced diabetic rat. J Lab Clin Med. 2001;138:177–185
-
.
Paradoxes of nitric oxide in the diabetic kidney.
Am J Physiol. 2003;284:F1121–F1137
- Role of nitric oxide in the early renal changes induced by high fructose diet in rats. Kidney Blood Press Res. 2002;25:363–369
- Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats. Diabetologia. 1997;40:1141–1151
-
.
Glucose-induced down-regulation of NO production and inducible NOS expression in cultured rat aortic vascular smooth muscle cells (Role of protein kinase C).
Biochem Biophys Res Commun. 1996;24:857–863
- High glucose inhibits expression of inducible and constitutive nitric oxide synthase in bovine aortic endothelial cells. Acta Pharmacol Sin. 2000;21:325–328
-
.
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK inactivation.
Am J Physiol. 2000;278:C81–C91
-
Chronic diabetic nephropathy (Role of inducible nitric oxide synthase).
Pediatric Nephrol. 2002;17:20–29
- Nitric oxide (A potential mediator of amino acid-induced renal hyperemia and hyperfiltration). J Am Soc Nephrol. 1991;1:1271–1277
- Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats (Role of NO). Am J Physiol. 1993;265:F886–F895
- . Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes. Diabetes. 1994;43:1190–1197
- . Role of EDRF (nitric oxide) in diabetic renal hyperfiltration. Kidney Int. 1993;43:1306–1312
- Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes. Nephron. 1996;74:136–143
- Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats. Diabetologia. 1996;39:1036–1040
- The effects of endothelin-1 and NG-nitro-L-arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol. 1991;103:1321–1326
- Role of nitric oxide in intrarenal hemodynamics in experimental diabetes mellitus in rats. Am J Physiol. 1999;277:R725–R733
- Role of nitric oxide in intrarenal hemodynamics in experimental diabetes mellitus in rats. Am J Physiol. 1999;277:R725–R733
- . Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats. Am J Physiol. 1993;264:R952–R956
-
.
Nitric oxide in diabetic nephropathy.
Kidney Int. 1997;52(suppl 60):S46–S53
- Nitric oxide synthase inhibition in a spontaneously hypertensive rat model of diabetic nephropathy. Clin Exp Pharmacol Physiol. 1997;24:451–453
- L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J Am Soc Nephrol. 1993;4:1039–1045
- Arginine reduces kidney collagen accumulation, cross-linking, lipid peroxidation, glycoxidation, kidney weight and albuminuria in the diabetic kk mouse. Nephron. 1997;75:213–218
- . Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy. J Am Soc Nephrol. 1995;5:1498–1507
- . Can L-arginine manipulation reduce renal disease?. Semin Nephrol. 1999;19:304–309
- Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes. Diabetes Res Clin Pract. 2001;53:149–159
- Nitric oxide modulation of renal and cardiac hemodynamics in type 2 diabetes. Eur J Endocrinol. 2002;146:687–694
- Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin. J Am Soc Nephrol. 2001;12:2125–2130
- Increased basal levels of plasma nitric oxide in type 2 diabetic subjects. Relationship to microvascular complications. J Diabetes Complications. 2001;15:135–143
- Endothelium-dependent relaxation in peripheral vasculature and kidney of non-insulin-dependent diabetes mellitus. J Diabetes Complications. 1995;9:203–207
- Duplex sonographic registration of age and diabetes-related loss of renal vasodilatory response to nitroglycerine. Nephrol Dial Transplant. 2000;15:827–832
- Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy. Kidney Int. 2000;57:1968–1972
- Endothelial nitric oxide synthase intron 4 polymorphism influences the progression of renal disease. Nephron. 2001;89:219–223
- . Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes. Diabetes. 2000;49:500–503
- Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases. Nephrol Dial Transplant. 1999;14:2898–2902
-
.
Angiotensin II signaling activities the NO-cGMP pathway in rat proximal tubules.
Life Sci. 1998;63:75–80
-
Changes in NOS activity and protein expression during acute and prolonged ANG II administration.
Am J Physiol. 2002;282:R31–R37
- Angiotensin II stimulates synthesis of endothelial nitric oxide synthase. Hypertension. 1998;31:283–288
- . Protective effect of angiotensin II induced increase in nitric oxide in renal medullary circulation. Hypertension. 1998;31:271–276
- Angiotensin II stimulates nitric oxide release in isolated perfused renal arteries. Pflugers Arch. 1998;435:432–434
- Angiotensin II inhibits interleukin-1β induced nitric oxide production in cultured rat mesangial cells. Kidney Int. 1999;55:1277–1283
- Angiotensin II inhibits inducible nitric oxide synthase in tubular MCT cells by a posttranscriptional mechanism. J Am Soc Nephrol. 1997;8:551–557
- Angiotensin II type 1 receptor-mediated inhibition of cytokine-stimulated inducible nitric oxide synthase expression in vascular smooth muscle cells. Blood Press. 1994;5(Suppl):32–37
- Oxidative stress and nitric oxide synthase in rat diabetic nephropathy (Effects of ACEI and ARB). Kidney Int. 2002;61:186–194
- Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy. Diabetes. 2002;51:3274–3282
- Renal and ocular hemodynamic effects of insulin. Diabetes. 1997;46:1868–1874
- . Effect of hyperinsulinemia on renal function and nitrate/nitrite excretion in healthy subjects. Clin Exp Pharmacol Physiol. 1999;26:336–341
-
.
Insulin stimulates inducible nitric oxide synthesis in normal human mesangial cells by augmenting cellular uptake of L-arginine.
Nephrol Dial Transplant. 2003;18:49
- Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Diabetes. 2002;51:3450–3460
-
.
Role of nitric oxide in the regulation of insulin secretion by pancreatic islet cells.
J Am Soc Nephrol. 2003;14:323A
- . Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes. 1994;43:1–8
- . A central role for protein kinase C overactivity in diabetic glomerulosclerosis (Implications for prevention with antioxidants, fish oil, and ACE inhibitors). Med Hypotheses. 1998;50:155–165
-
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase.
J Biol Chem. 2001;25:17625–17628
- Increased renal production of TGF-beta 1 in patients with type II diabetes mellitus. Diabetes. 1997;46:854–859
- . Diabetic nephropathy and transforming growth factor-beta (Transforming our view of glomerulosclerosis and fibrosis build-up). Semin Nephrol. 2003;23:532–543
- Angiotensin II stimulates extracellular matrix protein synthesis through induction of TGF-beta expression in rat glomerular mesangial cells. J Clin Invest. 1994;93:2431–2437
- Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells. J Biol Chem. 2002;277:9880–9888
- Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. Am J Kidney Dis. 2002;39:486–492
- T)-786)->C polymorphism of the endothelial nitric oxide synthase gene influences the progression of renal disease. Nephron. 2002;91:747–751
- Association of a missense Glu298Asp mutation of the endothelial nitric oxide synthase gene with end stage renal disease. Clin Chem. 2000;46:1858–1860
- A common Glu298->Asp (894G->T) mutation at exon 7 of the endothelial nitric oxide synthase gene and vascular complications in type 2 diabetes. Diabetes Care. 1998;21:2195–2196
- Association of eNOS Glu298Asp polymorphism with end stage renal disease. Hypertension. 2002;40:535–540
- . The association between polymorphism of endothelial nitric oxide synthase gene and diabetic nephropathy. Zhonghua Nei Ke Za Zhi. 2001;40:729–732
- Genetic analysis of nitric oxide and endothelin in end-stage renal disease. Nephrol Dial Transplant. 2000;15:1794–1800
- Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. Horm Metab Res. 2000;32:80–83
- Endothelial nitric oxide synthase gene and the development of diabetic nephropathy. Diabetes Res Clin Pract. 2002;58:179–185
- Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia. 2003;46:426–428
- Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int. 2000;57:405–413
- CCTTT-repeat polymorphism in the human NOS2- promoter confers low risk of diabetic nephropathy in type 1 diabetic patients. Diabetes Care. 2000;23:560–562
PII: S0270-9295(04)00053-1
doi: 10.1016/j.semnephrol.2004.04.005
© 2004 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 24, Issue 4
, Pages 333-344
, July 2004
