Nitric oxide and tubulointerstitial nephritides

Mattana, Joseph; Adamidis, Ananea; Singhal, Pravin C

doi:10.1016/j.semnephrol.2004.04.006

« Previous Next »Seminars in Nephrology
Volume 24, Issue 4 , Pages 345-353, July 2004

Nitric oxide and tubulointerstitial nephritides

Joseph Mattana
- Research Institute, North Shore-Long Island Jewish Health System, Manhasset, NY, USA
- Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, the Long Island Campus for the Albert Einstein College of Medicine, Bronx, NY, USA
- Address reprint requests to Joseph Mattana, MD, Division of Kidney Diseases/Hypertension, Long Island Jewish Medical Center, 410 Lakeville Rd, Suite 207, New Hyde Park, NY 11040 USA
Ananea Adamidis
- Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, the Long Island Campus for the Albert Einstein College of Medicine, Bronx, NY, USA
Pravin C Singhal
- Research Institute, North Shore-Long Island Jewish Health System, Manhasset, NY, USA
- Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, the Long Island Campus for the Albert Einstein College of Medicine, Bronx, NY, USA

Abstract

As part of the exponential growth in our understanding of nitric oxide (NO) in health and disease over the past 2 decades, the kidney has become appreciated as a major site where NO may play a number of important roles. Although earlier work on the kidney focused more on effects of NO at the level of larger blood vessels and glomeruli, there has been a rapidly growing body of work showing critical roles for NO in tubulointerstitial disease. In this review we discuss some of the recent contributions to this important field.