Seminars in Nephrology
Volume 24, Issue 5 , Pages 408-412 , September 2004

C-reactive protein is a significant predictor of vascular calcification of both aorta and hand arteries

  • Eiji Ishimura

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan
    • Corresponding Author InformationAddress reprint requests to: Eiji Ishimura, MD, PhD, Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    • ,
  • Senji Okuno

      Affiliations

    • Shirasagi Hospital Kidney Center, Osaka, Japan
    • ,
  • Kayoko Kitatani

      Affiliations

    • Shirasagi Hospital Kidney Center, Osaka, Japan
    • ,
  • Kiyoshi Maekawa

      Affiliations

    • Shirasagi Hospital Kidney Center, Osaka, Japan
    • ,
  • Tsuyoshi Izumotani

      Affiliations

    • Shirasagi Hospital Kidney Center, Osaka, Japan
    • ,
  • Tomoyuki Yamakawa

      Affiliations

    • Shirasagi Hospital Kidney Center, Osaka, Japan
    • ,
  • Shuichi Jono

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan
    • ,
  • Tetsuo Shoji

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan
    • ,
  • Atsushi Shioi

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan
    • ,
  • Masaaki Inaba

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan
    • ,
  • Shaul G. Massry

      Affiliations

    • Division of Nephrology, University of Southern California, Los Angeles, CAUSA
    • ,
  • Yoshiki Nishizawa

      Affiliations

    • Osaka City University Graduate School of Medicine, Osaka, Japan

References 

  1. Ridker PM , Cushman M , Stampfer MJ , et al.   Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men . N Engl J Med . 1997;336:973–979
  2. Shoji T , Emoto M , Shinohara K , et al.   Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease . J Am Soc Nephrol . 2001;12:2117–2124
  3. C. Wanner , J. Zimmermann , S. Schwedler , et al.   Inflammation and cardiovascular risk in dialysis patients . Kidney Int . 2002;61(suppl 80):S99–S102
  4. Ross R . Atherosclerosis—an inflammatory disease . N Engl J Med . 1999;340:115–126
  5. Simon HB . Atherosclerosis or atheroscleritis (What’s in a name?) . Cardiology . 2002;98:111–112
  6. Lagrand WK , Visser CA , Hermens WT , et al.   C-reactive protein as a cardiovascular risk factor (More than an epiphenomenon?) . Circulation . 1999;100:96–102
  7. Jarvisalo MJ , Harmoinen A , Hakanen M , et al.   Elevated serum C-reactive protein levels and early arterial changes in healthy children . Arterioscler Thromb Vasc Biol . 2002;22:1323–1328
  8. Christian RC , Fitzpatrick LA . Vascular calcification . Curr Opin Nephrol Hypertens . 1999;8:443–448
  9. Demer LL , Tintut Y , Parhami F . Novel mechanisms in accelerated vascular calcification in renal disease patients . Curr Opin Nephrol Hypertens . 2002;11:437–443
  10. Giachelli CM . Ectopic calcification (Gathering hard facts about soft tissue mineralization) . Am J Pathol . 1999;154:671–675
  11. Ishimura E , Okuno S , Kitatani K , et al.   Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients—importance of glycaemic control . Diabetologia . 2002;45:1446–1448
  12. Arici M , Walls J . End-stage renal disease, atherosclerosis, and cardiovascular mortality (Is C-reactive protein the missing link?) . Kidney Int . 2001;59:407–414
  13. Sezer S , Ozdemir FN , Arat Z , et al.   Triad of malnutrition, inflammation, and atherosclerosis in hemodialysis patients . Nephron . 2002;91:456–462
  14. Lehto S , Niskanen L , Suhonen M , et al.   Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus . Arterioscler Thromb Vasc Biol . 1996;16:978–983
  15. Davies MR , Hruska KA . Pathophysiological mechanisms of vascular calcification in end-stage renal disease . Kidney Int . 2001;60:472–479
  16. Cozzolino M , Dusso AS , Slatopolsky E . Role of calcium-phosphate product and bone-associated proteins on vascular calcification in renal failure . J Am Soc Nephrol . 2001;12:2511–2516
  17. Goodman WG , Salusky IB . Non-invasive assessments of cardiovascular disease in patients with renal failure . Curr Opin Nephrol Hypertens . 2001;10:365–369
  18. Goodman WG , Goldin J , Kuizon BD , et al.   Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis . N Engl J Med . 2000;342:1478–1483
  19. Nitta K , Akiba T , Uchida K , et al.   The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term hemodialysis . Am J Kidney Dis . 2003;42:303–309
  20. O’Hare AM , Hsu CY , Bacchetti P , et al.   Peripheral vascular disease risk factors among patients undergoing hemodialysis . J Am Soc Nephrol . 2002;13:497–503
  21. Raggi P , Boulay A , Chasan-Taber S , et al.   Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? . J Am Coll Cardiol . 2002;39:695–701
  22. Cheung AK , Sarnak MJ , Yan G , et al.   Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients . Kidney Int . 2000;58:353–362
  23. Edmonds ME . Medial arterial calcification and diabetes mellitus . Z Kardiol . 2000;89(suppl 2):101–104
  24. Ridker PM , Hennekens CH , Buring JE , et al.   C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women . N Engl J Med . 2000;342:836–843
  25. Rost NS , Wolf PA , Kase CS , et al.   Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack (The Framingham study) . Stroke . 2001;32:2575–2579
  26. Pasceri V , Willerson JT , Yeh ET . Direct proinflammatory effect of C-reactive protein on human endothelial cells . Circulation . 2000;102:2165–2168
  27. Zhang YX , Cliff WJ , Schoefl GI , et al.   Coronary C-reactive protein distribution (Its relation to development of atherosclerosis) . Atherosclerosis . 1999;145:375–379
  28. Torzewski M , Rist C , Mortensen RF , et al.   C-reactive protein in the arterial intima (Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis) . Arterioscler Thromb Vasc Biol . 2000;20:2094–2099
  29. Zwaka TP , Hombach V , Torzewski J . C-reactive protein-mediated low density lipoprotein uptake by macrophages (Implications for atherosclerosis) . Circulation . 2001;103:1194–1197
  30. Wang AY , Woo J , Wang M , et al.   Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients . J Am Soc Nephrol . 2001;12:1927–1936
  31. Tintut Y , Patel J , Territo M , et al.   Monocyte/macrophage regulation of vascular calcification in vitro . Circulation . 2002;105:650–655
  32. Nitta K , Ishizuka T , Horita S , et al.   Soluble osteopontin and vascular calcification in hemodialysis patients . Nephron . 2001;89:455–458

PII: S0270-9295(04)00091-9

doi: 10.1016/j.semnephrol.2004.06.008

Seminars in Nephrology
Volume 24, Issue 5 , Pages 408-412 , September 2004

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