Seminars in Nephrology
Volume 24, Issue 5 , Pages 431-436 , September 2004

Inflammation: Cause of vascular disease and malnutrition in dialysis patients

  • George A. Kaysen

      Affiliations

    • Division of Nephrology, Department of Medicine University of California Davis, Davis, CA, USA
    • Department of Veteran’s Affairs Northern California Health Care System, Mather, CA, USA
    • Corresponding Author InformationAddress reprint requests to George A. Kaysen, MD, PhD, Chief, Division of Nephrology, University of California Davis, TB 136, Davis, CA 95616

References 

  1. United States Renal Data System (1995 Annual Data Report) . Am J Kidney Dis . 1995;26:509–594
  2. Yeun JY , Levine RA , Mantadilok V , et al.   C-reactive protein predicts all cause and cardiovascular mortality in hemodialysis patients . Am J Kidney Dis . 2000;35:469–476
  3. Avram MM , Goldwasser P , Erroa M , et al.   Predictors of survival in continuous ambulatory peritoneal dialysis patients (The importance of prealbumin and other nutritional and metabolic markers) . Am J Kidney Dis . 1994;23:91–98
  4. Sreedhara R , Avram MM , Blanco M, et al.   Prealbumin is the best nutritional predictor of survival in hemodialysis and peritoneal dialysis . Am J Kidney Dis . 1996;28:937–942
  5. Lowrie EG , Lew NL . Death risk in hemodialysis patients (The predictive value of commonly measured variables and an evaluation of death rate differences between facilities) . Am J Kidney Dis . 1990;15:458–482
  6. Rigaud D , Hassid J , Meulemans A , et al.   A paradoxical increase in resting energy expenditure in malnourished patients near death (The king penguin syndrome) . Am J Clin Nutr . 2000;72:355–360
  7. Moldawer LL , Copeland EM . Proinflammatory cytokines, nutritional support, and the cachexia syndrome (Interactions and therapeutic options) . Cancer . 1997;79:1828–1839
  8. Michie HR . Metabolism of sepsis and multiple organ failure . World J Surg . 1996;20:460–464
  9. Fung WP , Thomas T , Dickson PW , et al.   Structure and expression of the rat transthyretin (prealbumin) gene . J Biol Chem . 1988;263:480–488
  10. Samadani U , Qian X , Costa RH . Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform . Gene Expr . 1996;6:23–33
  11. Banks RE , Forbes MA , Storr M , et al.   The acute phase protein response in patients receiving subcutaneous IL-6 . Clin Exp Immunol . 1995;102:217–223
  12. Clark GH , Fraser CG . Biological variation of acute phase proteins . Ann Clin Biochem . 1993;30:373–376
  13. Milland J , Tsykin A , Thomas T , et al.   Gene expression in regenerating and acute-phase rat liver . Am J Physiol . 1990;259:G340–G347
  14. Moshage HJ , Janssen JAM , Franssen JH , et al.   Study of the molecular mechanisms of decreased liver synthesis of albumin in inflammation . J Clin Invest . 1987;79:1635–1641
  15. Kaysen GA , Rathore V , Shearer GC , et al.   Mechanisms of hypoalbuminemia in hemodialysis patients . Kidney Int . 1995;48:510–516
  16. Yeun JY , Kaysen GA . Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients . Am J Kidney Dis . 1997;30:923–927
  17. Jensen LE , Whitehead AS . Regulation of serum amyloid A protein expression during the acute-phase response . Biochem J . 1998;334:489–503
  18. Wang Y , Ripperger J , Fey GH , et al.   Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells . Hepatology . 1999;30:682–697
  19. Stenvinkel P , Heimburger O , Paultre F , et al.   Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure . Kidney Int . 1999;55:1899–1911
  20. Zimmermann J , Herrlinger S , Pruy A , et al.   Inflammation enhances cardiovascular risk and mortality in hemodialysis patients . Kidney Int . 1999;55:648–658
  21. Li YP , Lecker SH , Chen Y , et al.   TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k . FASEB J . 2003;17:1048–1057
  22. Guttridge DC , Mayo MW , Madrid LV , et al.   NF-kappaB-induced loss of MyoD messenger RNA (Possible role in muscle decay and cachexia) . Science . 2000;289:2363–2366
  23. Wang ZM , Sun YG , Heymsfield SB . Urinary creatinine-skeletal muscle mass method (A prediction equation based on computerized axial tomography) . Biomed Environ Sci . 1996;9:185–190
  24. Michael J . Tisdale protein loss in cancer cachexia . Science . 2000;29:2293–2294
  25. Kaysen GA , Chertow GM , Adhikarla R , et al.   Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients . Kidney Int . 2001;60:333–340
  26. Ferrucci L , Penninx BW , Volpato S , et al.   Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels . J Am Geriatr Soc . 2002;50:1947–1954
  27. Yeun JY , Kaysen GA . Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients . Am J Kidney Dis . 1997;30:923–927
  28. Kim H , Bologa R , Parker T , et al.   Serum IL-6 level as an indicator of survival outcome in CAPD patients . J Am Soc Nephrol . 1999;10:246A; (abstr)
  29. Ridker PM , Glynn RJ , Hennekens CH . C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction . Circulation . 1998;97:2007–2011
  30. Danesh J , Collins R , Appleby P , et al.   Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease (Meta-analyses of prospective studies) . JAMA . 1998;279:1477–1482
  31. Ridker PM , Buring JE , Shih J , et al.   Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women . Circulation . 1998;98:731–733
  32. Koenig W , Sund M , Frohlich M , et al.   C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men (Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992) . Circulation . 1999;99:237–242
  33. Ridker PM , Cushman M , Stampfer MJ , et al.   Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men . N Engl J Med . 1997;336:973–979
  34. Danesh J , Collins R , Appleby P , et al.   Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease (Meta-analyses of prospective studies) . JAMA . 1998;279:1477–1482
  35. Suzuki K , Kuriyama M , Saito T , et al.   Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5′-flanking region . J Clin Invest . 1997;15:1361–1366
  36. Dieplinger H , Lackner C , Kronenberg F , et al.   Elevated plasma concentrations of lipoprotein(a) in patients with end-stage renal disease are not related to the size polymorphism of apolipoprotein(a) . J Clin Invest . 1993;91:397–401
  37. Van Lenten BJ , Hama SY , de Beer FC , et al.   Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures . J Clin Invest . 1995;96:2758–2767
  38. Pruzanski W , Stefanski E , de Beer FC , et al.   Comparative analysis of lipid composition of normal and acute-phase high density lipoproteins . J Lipid Res . 2000;41:1035–1047
  39. De Beer FC , Fagan EA , Hughes GRV , et al.   Serum amyloid-A protein concentration in inflammatory diseases and its relationship to the incidence of reactive systemic amyloidosis . Lancet . 1982;2:231–234
  40. Cockerill GW , Huehns TY , Weerasinghe A , et al.   Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation . Circulation . 2001;103:108–112
  41. Cockerill GW , Saklatvala J , Ridley SH , et al.   High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2 . Arterioscler Thromb Vasc Biol . 1999;19:910–917
  42. Pruzanski W , Stefanski E , Kopilov J , et al.   Mitogenic effect of lipoproteins on human vascular smooth muscle cells (The impact of hydrolysis by gr II A phospholipase A(2)) . Lab Invest . 2001;81:757–765
  43. Cockerill GW , Huehns TY , Weerasinghe A , et al.   Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation . Circulation . 2001;103:108–112
  44. Pruzanski W , Stefanski E , de Beer FC , et al.   Comparative analysis of lipid composition of normal and acute-phase high density lipoproteins . J Lipid Res . 2000;41:1035–1047
  45. Herbelin A , Urena P , Nguyen AT , et al.   Elevated circulating levels of interleukin-6 in patients with chronic renal failure . Kidney Int . 1991;39:954–960
  46. Pereira BJ , Shapiro L , King AJ , et al.   Plasma levels of IL-1 beta, TNF alpha and their specific inhibitors in undialyzed chronic renal failure, CAPD and hemodialysis patients . Kidney Int . 1994;45:890–896
  47. Cavaillon JM , Poignet JL , Fitting C , et al.   Serum interleukin-6 in long-term hemodialyzed patients . Nephron . 1992;60:307–313
  48. Ceballos-Picot I , Witko-Sarsat V , Merad-Boudia M , et al.   Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure . Free Radic Biol Med . 1996;21:845–853
  49. Loughrey CM , Young IS , Lightbody JH , et al.   Oxidative stress in haemodialysis . QJM . 1994;87:679–683
  50. Odetti P , Cosso L , Pronzato MA , et al.   Plasma advanced glycosylation end-products in maintenance haemodialysis patients . Nephrol Dial Transplant . 1995;10:2110–2113
  51. Miyata T , van Ypersele de Strihou C , Kurokawa K , et al.   Alterations in nonenzymatic biochemistry in uremia (Origin and significance of “carbonyl stress” in long-term uremic complications) . Kidney Int . 1999;55:389–399
  52. Bologa RM , Levine DM , Parker TS , et al.   Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients . Am J Kidney Dis . 1998;32:107–114
  53. Kaysen GA , Stevenson FT , Depner TA . Determinants of albumin concentration in hemodialysis patients . Am J Kidney Dis . 1997;29:658–668
  54. Parker TF , Wingard RL , Husni L , et al.   Effect of the membrane biocompatibility on nutritional parameters in chronic hemodialysis patients . Kidney Int . 1996;49:551–556
  55. Tielemans C , Husson C , Schurmans T , et al.   Effects of ultrapure and non-sterile dialysate on the inflammatory response during in vitro hemodialysis . Kidney Int . 1996;49:236–243
  56. David S , Tetta C , Canino F , et al.   Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate . ASAIO J . 1993;39:M773–M777
  57. Kaysen GA , Dubin JA , Müller HG , et al.  HEMO Group   The acute-phase response varies with time and predicts serum albumin levels in hemodialysis patients . Kidney Int . 2000;58:346–352
  58. Keys A , Brozek J , Henschel A , et al.   The Biology of Human Starvation . Minneapolis: University of Minnesota Press; 1950;

 Supported in part by the research service of the United States Department of Veterans Affairs, in part by a grant from the National Institutes of Health RO1 DK 50777, and in part by a gift from Dialysis Clinics Incorporated, Nashville, TN.

PII: S0270-9295(04)00092-0

doi: 10.1016/j.semnephrol.2004.06.009

Seminars in Nephrology
Volume 24, Issue 5 , Pages 431-436 , September 2004