Seminars in Nephrology
Volume 24, Issue 5 , Pages 396-400 , September 2004

Factors for increased morbidity and mortality in uremia: Hyperphosphatemia

  • Nathan W. Levin

      Affiliations

    • Renal Research Institute, New York, NY, USA
    • Corresponding Author InformationNathan W. Levin, MD, Medical and Research Director, Renal Research Institute, 207 E 94th St, Suite 303, New York, NY 10128
    • ,
  • Frank A. Gotch

      Affiliations

    • Renal Research Institute, New York, NY, USA
    • ,
  • Martin K. Kuhlmann

      Affiliations

    • Renal Research Institute, New York, NY, USA

References 

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  3. Blacher J , Guerin AP , Pannier B , et al.   Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease . Hypertension . 2001;38:938–942
  4. Slatopolsky E , Brown A , Dusso A . Role of phosphorus in the pathogenesis of secondary hyperparathyroidism . Am J Kidney Dis . 2001;37(suppl 2):S54–S57
  5. Goodman WG , Goldin J , Kuizon BD , et al.   Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis . N Engl J Med . 2000;342:1478–1483
  6. Taylor AJ , Burke AP , O’Malley PG , et al.   A comparison of the Framingham risk index, coronary artery calcification, and culprit plaque morphology in sudden cardiac death . Circulation . 2000;101:1243–1248
  7. Jono S , McKee MD , Murry CE , et al.   Phosphate regulation of vascular smooth muscle cell calcification . Circ Res . 2000;87:E10–E17
  8. Giachelli CM . Vascular calcification (In vitro evidence for the role of inorganic phosphate) . J Am Soc Nephrol . 2003;14(suppl 4):S300–S304
  9. NKF-K/DOQI clinical practice guidelines for nutrition in chronic renal failure . Am J Kidney Dis . 2000;35(suppl):S1–s140
  10. Bleyer AJ , Burke SK , Dillon M , et al.   A comparison of the calcium-free phosphate binder sevelamer hydrochloride with calcium acetate in the treatment of hyperphosphatemia in hemodialysis patients . Am J Kidney Dis . 1999;33:694–701
  11. Backenroth R . Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients . Kidney Int . 2003;64:1533
  12. Chertow GM , Burke SK , Raggi P . Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients . Kidney Int . 2002;62:245–252
  13. Katsumata K , Kusano K , Hirata M . Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats . Kidney Int . 2003;64:441–450
  14. Chertow GM , Burke SK , Dillon MA , et al.   Long-term effects of sevelamer hydrochloride on the calcium × phosphate product and lipid profile of hemodialysis patients . Nephrol Dial Transplant . 1999;14:2907–2914
  15. Braunlin W , Zhorov E , Guo A , et al.   Bile acid binding to sevelamer HCl . Kidney Int . 2002;62:611–619
  16. Joy MS , Finn WF . Randomized, double blind, placebo-controlled, dose titration, phase III study assessing the efficacy and tolerability of lanthanum carbonate (A new phosphate binder for the treatment of hyperphosphatemia) . Am J Kidney Dis . 2003;42:96–107
  17. Hou SH , Zhao J , Ellman CF , et al.   Calcium and phosphorus fluxes during hemodialysis with low calcium dialysate . Am J Kidney Dis . 1991;18:217–224
  18. Fernandez E , Borras M , Pais B , et al.   Low calcium dialysate stimulates parathormon secretion and its long term use worsens secondary hyperparathyroidism . J Am Soc Nephrol . 1995;6:132–135
  19. Yokoyama K , Kagami S , Ohkido I , et al.   The negative calcium balance is involved in the stimulation of PTH secretion . Nephron . 2002;92:86–90
  20. DeSoi CA , Umans JG . Phosphate kinetics during high-flux hemodialysis . J Am Soc Nephrol . 1993;4:1214–1218
  21. Spalding EM , Chamney PW , Farrington K . Phosphate kinetics during hemodialysis (Evidence for biphasic regulation) . Kidney Int . 2002;61:655–667
  22. Minutolo R , Bellizzi V , Cioffi M , et al.   Postdialytic rebound of serum phosphorus (Pathogenetic and clinical insights) . J Am Soc Nephrol . 2002;13:1046–1054
  23. Mucsi I , Hercz G , Uldall R , et al.   Control of serum phosphate without any phosphate binders in patients treated with nocturnal hemodialysis . Kidney Int . 1998;53:1399–1404
  24. Gotch FA , Panlilio F , Sergeyeva O , et al.   A kinetic model of inorganic phosphorus mass balance in hemodialysis therapy . Blood Purif . 2003;21:51–57

PII: S0270-9295(04)00094-4

doi: 10.1016/j.semnephrol.2004.06.011

Seminars in Nephrology
Volume 24, Issue 5 , Pages 396-400 , September 2004

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