Seminars in Nephrology
Volume 24, Issue 5 , Pages 413-416 , September 2004

Uremic vasculopathy

  • Sharon M. Moe

      Affiliations

    • Indiana University School of Medicine, Indianapolis, INUSA
    • Corresponding Author InformationAddress reprint requests to: Sharon M. Moe, MD, FACP, Associate Professor of Medicine, Associate Dean for Research Support, Indiana University School of Medicine, 1001 W. 10th St, OPW 526, Indianapolis, IN 46260

References 

  1. Foley RN , Parfrey PS , Sarnak MJ . Clinical epidemiology of cardiovascular disease in chronic renal disease . Am J Kidney Dis . 1998;32(suppl 3):S112–S119
  2. Lindner A , Charra B , Sherrard DJ , et al.   Accelerated atherosclerosis in prolonged maintenance hemodialysis . N Engl J Med . 1974;290:697–701
  3. Parfrey PS . Is renal insufficiency an atherogenic state? Reflections on prevalence, incidence, and risk . Am J Kidney Dis . 2001;37:154–156
  4. Cheung AK , Sarnak MJ , Yan G , et al.   Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients . Kidney Int . 2000;58:353–362
  5. Stary HC . Natural history of calcium deposits in atherosclerosis progression and regression . Z Kardiol . 2000;89(suppl 2):28–35
  6. Shanahan CM , Cary NR , Salisbury JR , et al.   Medial localization of mineralization-regulating proteins in association with Monckeberg’s sclerosis (Evidence for smooth muscle cell-mediated vascular calcification) . Circulation . 1999;100:2168–2176
  7. H. Selye , G. Gabbiani , R. Strebel . In: Sensitization to calciphylaxis by endogenous parathyroid hormone . Chicago: University of Chicago Press; 1962;p. 554–558
  8. Coates T , Kirkland GS , Dymock RB , et al.   Cutaneous necrosis from calcific uremic arteriolopathy . [see comments] Am J Kidney Dis . 1998;32:384–391
  9. Ibels LS , Alfrey AC , Huffer WE , et al.   Arterial calcification and pathology in uremic patients undergoing dialysis . Am J Med . 1979;66:790–796
  10. Schwarz U , Buzello M , Ritz E , et al.   Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure . Nephrol Dial Transplant . 2000;15:218–223
  11. London GM , Guerin AP , Marchais SJ , et al.   Arterial media calcification in end-stage renal disease (Impact on all-cause and cardiovascular mortality) . Nephrol Dial Transplant . 2003;18:1731–1740
  12. Braun J , Oldendorf M , Moshage W , et al.   Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients . Am J Kidney Dis . 1996;27:394–401
  13. Goodman WG , Goldin J , Kuizon BD , et al.   Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis . N Engl J Med . 2000;342:1478–1483
  14. Guerin AP , London GM , Marchais SJ , et al.   Arterial stiffening and vascular calcifications in end-stage renal disease . Nephrol Dial Transplant . 2000;15:1014–1021
  15. Moe SM , O’Neill KD , Fineberg N , et al.   Assessment of vascular calcification in ESRD patients using spiral CT . Nephrol Dial Transplant . 2003;18:1152–1158
  16. Chertow GM , Burke SK , Raggi P . Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients . Kidney Int . 2002;62:245–252
  17. S.M. Moe , N.X. Chen . Calciphylaxis and vascular calcification (A continuum of extra-skeletal osteogenesis) . Pediatr Nephrol . 2003;18(10):969–975
  18. Raggi P , Boulay A , Chasan-Taber S , et al.   Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? . J Am Coll Cardiol . 2002;39:695–701
  19. Moe SM, O’Neill KD, Reselerova M, et al: Natural history of vascular calcification in dialysis and transplant patients. Nephrol Dial Transplant (in press)
  20. Ahmed S , O’Neill KD , Hood AF , et al.   Calciphylaxis is associated with hyperphosphatemia and increased osteopontin expression by vascular smooth muscle cells . Am J Kidney Dis . 2001;37:1267–1276
  21. Moe SM , O’Neill KD , Duan D , et al.   Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins . Kidney Int . 2002;61:638–647
  22. Bostrom K , Watson KE , Horn S , et al.   Bone morphogenetic protein expression in human atherosclerotic lesions . J Clin Invest . 1993;91:1800–1809
  23. Shanahan CM , Cary NR , Metcalfe JC , et al.   High expression of genes for calcification-regulating proteins in human atherosclerotic plaques . J Clin Invest . 1994;93:2393–2402
  24. Proudfoot D , Skepper JN , Shanahan CM , et al.   Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression . Arterioscler Thromb Vasc Biol . 1998;18:379–388
  25. Chen NX , O’Neill KD , Duan D , et al.   Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells . Kidney Int . 2002;62:1724–1731
  26. Jono S , McKee MD , Murry CE , et al.   Phosphate regulation of vascular smooth muscle cell calcification . Circ Res . 2000;87:E10–E17
  27. Moe SM , Duan D , Doehle BP , et al.   Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels . Kidney Int . 2003;63:1003–1011
  28. Jono S , Peinado C , Giachelli CM . Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcification . J Biol Chem . 2000;275:20197–20203
  29. Ducy P , Zhang R , Geoffroy V , et al.   Osf2/Cbfa1 (A transcriptional activator of osteoblast differentiation) . [see comments] Cell . 1997;89:747–754
  30. Komori T , Yagi H , Nomura S , et al.   Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts . [see comments] Cell . 1997;89:755–764
  31. Steitz SA , Speer MY , Curinga G , et al.   Smooth muscle cell phenotypic transition associated with calcification (Upregulation of Cbfa1 and downregulation of smooth muscle lineage markers) . Circ Res . 2001;89:1147–1154
  32. Tyson KL , Reynolds JL , McNair R , et al.   Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification . Arterioscler Thromb Vasc Biol . 2003;23:489–494
  33. Parhami F , Garfinkel A , Demer LL . Role of lipids in osteoporosis . Arterioscler Thromb Vasc Biol . 2000;20:2346–2348
  34. Ketteler M , Vermeer C , Wanner C , et al.   Novel insights into uremic vascular calcification (Role of matrix Gla protein and alpha-2Heremans Schmid glycoprotein/fetuin) . Blood Purif . 2002;20:473–476
  35. Ketteler M , Bongartz P , Westenfeld R , et al.   Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis (A cross-sectional study) . Lancet . 2003;361:827–833
  36. Mori K , Shioi A , Jono S , et al.   Expression of matrix Gla protein (MGP) in an in vitro model of vascular calcification . FEBS Lett . 1998;433:19–22
  37. Luo G , Ducy P , McKee MD , et al.   Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein . Nature . 1997;386:78–81
  38. Schafer C , Heiss A , Schwarz A , et al.   The serum protein alpha 2Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification . J Clin Invest . 2003;112:357–366

PII: S0270-9295(04)00098-1

doi: 10.1016/j.semnephrol.2004.06.015

Seminars in Nephrology
Volume 24, Issue 5 , Pages 413-416 , September 2004