Seminars in Nephrology
Volume 25, Issue 1 , Pages 56-60 , January 2005

Uric acid and preeclampsia

  • Chun Lam

      Affiliations

    • Department of Medicine and the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
    • ,
  • Kee-Hak Lim

      Affiliations

    • Department of Medicine and the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
    • ,
  • Duk-Hee Kang

      Affiliations

    • Department of Medicine and the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
    • ,
  • S. Ananth Karumanchi

      Affiliations

    • Department of Medicine and the Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
    • Corresponding Author InformationAddress reprint requests to S. Ananth Karumanchi, MD, Beth Israel Deaconess Medical Center, Renal Division, Dana 517, 330 Brookline Ave, Boston, MA 02215.

References 

  1. Slemons J , Bogert L . The uric acid content of maternal and fetal blood . J Biol Chem . 1917;32:63–69
  2. Stander H , Cadden J . Blood chemistry in preeclampsia and eclampsia . Am J Obstet Gynecol . 1934;28:856–871
  3. Redman CW , Beilin LJ , Bonnar J , et al.   Plasma-urate measurements in predicting fetal death in hypertensive pregnancy . Lancet . 1976;1:1370–1373
  4. Nochy D , Birembaut P , Hinglais N , et al.   Renal lesions in the hypertensive syndromes of pregnancy (Immunomorphological and ultrastructural studies in 114 cases) . Clin Nephrol . 1980;13:155–162
  5. Weerasekera DS , Peiris H . The significance of serum uric acid, creatinine and urinary microprotein levels in predicting pre-eclampsia . J Obstet Gynaecol . 2003;23:17–19
  6. Williams KP , Galerneau F . The role of serum uric acid as a prognostic indicator of the severity of maternal and fetal complications in hypertensive pregnancies . J Obstet Gynaecol Can . 2002;24:628–632
  7. Redman CW , Bonnar J . Plasma urate changes in pre-eclampsia . BMJ . 1978;1:1484–1485
  8. Kang D , Finch J , Nakagawa T , et al.   Uric acid, endothelial dysfunction and pre-eclampsia (searching for a pathogenetic link) . J Hypertens . 2004;22:229–235
  9. Watanabe S , Kang DH , Feng L , et al.   Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity . Hypertension . 2002;40:355–360
  10. Maynard SE , Min JY , Merchan J , et al.   Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia . J Clin Invest . 2003;111:649–658
  11. Many A , Hubel CA , Roberts JM . Hyperuricemia and xanthine oxidase in preeclampsia, revisited . Am J Obstet Gynecol . 1996;174:288–291
  12. Johnson RJ , Kang DH , Feig D , et al.   Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? . Hypertension . 2003;41:1183–1190
  13. Maesaka JK , Fishbane S . Regulation of renal urate excretion (A critical review) . Am J Kidney Dis . 1998;32:917–933
  14. Merviel P , Ba R , Beaufils M , et al.   Lone hyperuricemia during pregnancy (Maternal and fetal outcomes) . Eur J Obstet Gynecol Reprod Biol . 1998;77:145–150
  15. Cohen SB , Kreiser D , Erez I , et al.   Effect of fetal number on maternal serum uric acid concentration . Am J Perinatol . 2002;19:291–296
  16. Simmonds HA , Stutchbury JH , Webster DR , et al.   Pregnancy and xanthinuria (Demonstration of fetal uric acid production?) . J Inherit Metab Dis . 1984;7:77–79
  17. Ferris TF , Gorden P . Effect of angiotensin and norepinephrine upon urate clearance in man . Am J Med . 1968;44:359–365
  18. Guidi E , Magni M , di Belgiojoso GB , et al.   Blood pressure in patients with four different primary glomerulopathies . Clin Exp Hypertens . 1984;6:1357–1366
  19. Saugstad OD . Hypoxanthine as measurement of hypoxia . Pediatr Res . 1975;9:158–161
  20. Lee FI , Loeffler FE . Gout and pregnancy . J Obstet Gynaecol Br Emp . 1962;69:299–304
  21. Kelsall JT , O’Hanlon DP . Gout during pregnancy . J Rheumatol . 1994;21:1365–1366
  22. Irgens HU , Reisaeter L , Irgens LM , et al.   Long term mortality of mothers and fathers after pre-eclampsia (Population based cohort study) . BMJ . 2001;323:1213–1217
  23. Sibai BM , el-Nazer A , Gonzalez-Ruiz A . Severe preeclampsia-eclampsia in young primigravid women (Subsequent pregnancy outcome and remote prognosis) . Am J Obstet Gynecol . 1986;155:1011–1016
  24. Mazzali M , Kanellis J , Han L , et al.   Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism . Am J Physiol . 2002;282:F991–F997
  25. Sanchez-Lozada LG , Tapia E , Avila-Casado C , et al.   Mild hyperuricemia induces glomerular hypertension in normal rats . Am J Physiol . 2002;283:F1105–F1110
  26. Mazzali M , Hughes J , Kim YG , et al.   Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism . Hypertension . 2001;38:1101–1106
  27. Kang DH , Nakagawa T , Feng L , et al.   A role for uric acid in the progression of renal disease . J Am Soc Nephrol . 2002;13:2888–2897
  28. Kanabrocki EL , Third JL , Ryan MD , et al.   Circadian relationship of serum uric acid and nitric oxide . JAMA . 2000;283:2240–2241
  29. Doehner W , Schoene N , Rauchhaus M , et al.   Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure (results from 2 placebo-controlled studies) . Circulation . 2002;105:2619–2624
  30. Farquharson CA , Butler R , Hill A , et al.   Allopurinol improves endothelial dysfunction in chronic heart failure . Circulation . 2002;106:221–226
  31. Kanellis J , Watanabe S , Li JH , et al.   Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2 . Hypertension . 2003;41:1287–1293
  32. Shi Y , Evans JE , Rock KL . Molecular identification of a danger signal that alerts the immune system to dying cells . Nature . 2003;425:516–521
  33. Bowen RS , Moodley J , Dutton MF , et al.   Oxidative stress in pre-eclampsia . Acta Obstet Gynecol Scand . 2001;80:719–725
  34. Many A , Westerhausen-Larson A , Kanbour-Shakir A , et al.   Xanthine oxidase/dehydrogenase is present in human placenta . Placenta . 1996;17:361–365
  35. Zhang Z , Blake DR , Stevens CR , et al.   A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury (The role of NADH as an electron donor) . Free Radic Res . 1998;28:151–164
  36. Kharb S . Total free radical trapping antioxidant potential in pre-eclampsia . Int J Gynaecol Obstet . 2000;69:23–26
  37. Santos CX , Anjos EI , Augusto O . Uric acid oxidation by peroxynitrite (Multiple reactions, free radical formation, and amplification of lipid oxidation) . Arch Biochem Biophys . 1999;372:285–294
  38. Toescu V , Nuttall SL , Martin U , et al.   Oxidative stress and normal pregnancy . Clin Endocrinol (Oxf) . 2002;57:609–613
  39. Walsh SW . Maternal-placental interactions of oxidative stress and antioxidants in preeclampsia . Semin Reprod Endocrinol . 1998;16:93–104
  40. Hink HU , Santanam N , Dikalov S , et al.   Peroxidase properties of extracellular superoxide dismutase (role of uric acid in modulating in vivo activity) . Arterioscler Thromb Vasc Biol . 2002;22:1402–1408
  41. Landmesser U , Drexler H . Toward understanding of extracellular superoxide dismutase regulation in atherosclerosis (A novel role of uric acid?) . Arterioscler Thromb Vasc Biol . 2002;22:1367–1368
  42. Mugge A , Elwell JH , Peterson TE , et al.   Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity . Am J Physiol . 1991;260:C219–C225
  43. Omar HA , Cherry PD , Mortelliti MP , et al.   Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation . Circ Res . 1991;69:601–608
  44. Thomas SR , Davies MJ , Stocker R . Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite . Chem Res Toxicol . 1998;11:484–494
  45. Patterson RA , Horsley ET , Leake DS . Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL (Important role of uric acid) . J Lipid Res . 2003;44:512–521
  46. Talosi G , Nemeth I , Pinter S . Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes . Eur J Obstet Gynecol Reprod Biol . 2001;99:25–32
  47. Gulmezoglu AM , Hofmeyr GJ , Oosthuisen MM . Antioxidants in the treatment of severe pre-eclampsia (an explanatory randomised controlled trial) . Br J Obstet Gynaecol . 1997;104:689–696

 Supported by National Institutes of Health grants (DK002825, DK64255) and the Carl Gottschalk award by the American Society of Nephrology (S.A.K.); and by a grant of the Korea Health 21 R & D Project, Ministry of Health & Welfare, Republic of Korea (02-PJ1-PG3-20599-0014) (D.-H.K.).

PII: S0270-9295(04)00152-4

doi: 10.1016/j.semnephrol.2004.09.009

Seminars in Nephrology
Volume 25, Issue 1 , Pages 56-60 , January 2005

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