Seminars in Nephrology
Volume 25, Issue 5 , Pages 312-321 , September 2005

Hormonal and Nonhormonal Mechanisms of Regulation of the Na,K-Pump in Collecting Duct Principal Cells

References 

  1. Féraille E , Doucet A . Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney (Hormonal control) . Physiol Rev . 2001;81:345–418
  2. Skou JC . Nobel lecture. The identification of the sodium-potassium pump . Biosci Rep . 1998;18:155–169
  3. Verrey F , Schaerer E , Zoerkler  , et al.   Regulation by aldosterone of Na+, K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells . J Cell Biol . 1987;104:1231–1237
  4. Cheval L , Doucet A . Measurement of Na-K-ATPase-mediated rubidium influx in single segments of the rat nephron . Am J Physiol . 1990;259:F111–F121
  5. Kellenberger S , Gautschi I , Rossier BC , et al.   Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel . J Clin Invest . 1998;101:2741–2750
  6. Horisberger JD , Diezi J . Effect of mineralocorticoids on Na+ and K+ excretion in the adrenalectomized rat . Am J Physiol . 1983;245:F89–F99
  7. El Mernissi G , Doucet A . Short term effect of aldosterone on renal sodium transport and tubular Na,K-ATPase in the rat . Pflugers Arch . 1983;339:139–146
  8. Losel RM , Feuring M , Falkenstein E , et al.   Nongenomic effects of aldosterone (Cellular aspects and clinical implications) . Steroids . 2002;67:493–498
  9. Le Moëllic C , Ouvrard-Pascaud A , Capurro C , et al.   Early nongenomic events in aldosterone action in renal collecting duct cells (PKCα activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response) . J Am Soc Nephrol . 2004;15:1145–1160
  10. Verrey F , Beron J , Spindler B . Corticosteroid regulation of renal Na,K-ATPase . Miner Electrolyte Metab . 1996;22:279–292
  11. Barlet-Bas C , Khadouri C , Marsy S , et al.   Sodium-independent in vitro induction of Na,K-ATPase by aldosterone in renal target cells (Permissive effect of triiodothyronine) . Proc Natl Acad Sci U S A . 1988;85:1707–1711
  12. Johnson JP , Jones D , Wiesmann WP . Hormonal regulation of Na,K-ATPase in cultured epithelial cells . Am J Physiol . 1986;251:C186–C190
  13. Leal T , Crabbé J . Effect of aldosterone on (Na+ + K+)-ATPase of amphibian sodium-transporting epithelial cells (A6) in culture . J Steroid Biochem . 1989;34:581–584
  14. Yagawa Y , Kawakami K , Nagano K . Cloning and analysis of the 5′-flanking region of rat Na,K-ATPase α1 subunit gene . Biochim Biophys Acta . 1990;1049:286–292
  15. Ernst SA , Gaeggeler HP , Geering K , et al.   Differential effect of aldosterone on expression of apical membrane proteins and of basolateral membrane β-subunit of Na,K-ATPase . J Cell Biol . 1986;103:465a; (abstr)
  16. El Mernissi G , Doucet A . Specific activity of Na,K-ATPase after adrenalectomy and hormone replacement along the rabbit nephron . Pflugers Arch . 1984;402:258–263
  17. Horster M , Schmid H , Schmidt U . Aldosterone in vitro restores nephron Na,K-ATPase of distal segments from adrenalectomized rabbits . Pflugers Arch . 1980;384:203–206
  18. Barlet-Bas C , Khaodouri C , Marsy S , et al.   Enhanced intracellular sodium concentration in kidney cells recruits a latent pool of Na,K-ATPase whose size is modulated by corticosteroids . J Biol Chem . 1990;265:7799–7803
  19. Blot-Chabaud M , Wanstok F , Bonvalet JP , et al.   Cell sodium-induced recruitment of Na+-K+-ATPase pumps in rabbit cortical collecting tubules is aldosterone-dependent . J Biol Chem . 1990;265:11676–11681
  20. Summa V , Mordasini D , Roger F , et al.   Short term effect of aldosterone on Na,K-ATPase cell surface expression in kidney collecting duct cells . J Biol Chem . 2001;276:47087–47093
  21. Bens M , Vallet V , Cluzeaud F , et al.   Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line . J Am Soc Nephrol . 1999;20:923–934
  22. Vandewalle A , Bens M , Duong Van Huyen JP . Immortalized kidney epithelial cells as tools for hormonally regulated ion transport studie . Curr Opin Nephrol Hypertens . 1999;8:581–587
  23. Robert-Nicoud M , Flahaut M , Elalouf JM , et al.   Transcriptome of a mouse kidney cortical collecting duct cell line (Effects of aldosterone and vasopressin) . Proc Natl Acad Sci U S A . 2001;98:2712–2716
  24. Hasler U , Mordasini D , Bens M , et al.   Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells . J Biol Chem . 2002;277:10379–10386
  25. Gonin S , Deschenes G , Roger F , et al.   Cyclic cAMP increases cell surface expression of functional Na,K-ATPase units in mammalian cortical collecting duct principal cells . Mol Biol Cell . 2001;13:255–264
  26. Chibalin AV , Katz AI , Berggren PO , et al.   Receptor mediated inhibition of renal Na,K-ATPase is associated with endocytosis of its α- and β-subunits . Am J Physiol . 1997;273:C1458–C1465
  27. Attali B , Latter H , Rachamim N , et al.   A corticosteroid-induced gene expressing an “IsK-like” K+ channel activity in Xenopus oocytes . Proc Natl Acad Sci U S A . 1995;92:6092–6096
  28. Capurro C , Coutry N , Bonvalet JP , et al.   Cellular localization and regulation of CHIF in kidney and colon . Am J Physiol . 1996;271:C753–C762
  29. Beguin P , Crambert G , Guennoun S , et al.   CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit . EMBO J . 2001;20:3993–4002
  30. Wald H , Goldstein O , Asher C , et al.   Aldosterone induction and epithelial distribution of CHIF . Am J Physiol . 1996;271:F322–F329
  31. Spindler B , Mastroberardino L , Custer M , et al.   Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia . Pflugers Arch . 1997;434:323–331
  32. Mastroberardino L , Spindler B , Forster I , et al.   Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes . Mol Biol Cell . 1998;9:3417–3427
  33. Stockhand JD . New ideas about aldosterone signalling in epithelia . Am J Physiol . 2002;282:F559–F576
  34. Boulkroun S , Fay M , Zennaro MC , et al.   Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene . J Biol Chem . 2002;277:31506–31515
  35. Waldegger S , Barth P , Raber G , et al.   Cloning and characterization of a putative serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume . Proc Natl Acad Sci U S A . 1997;94:4440–4445
  36. Park J , Leong ML , Buse P , et al.   Serum- and glucocorticoid-inducible kinase (SGK) is a target of the PI3-kinase-stimulated signalling pathway . EMBO J . 1999;18:3024–3033
  37. Loffing J , Zecevic M , Féraille E , et al.   Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system (Possible role of SGK) . Am J Physiol . 2001;280:F675–F682
  38. Loffing J , Summa V , Zecevic M , et al.   Mediators of aldosterone action in the renal tubule . Curr Opin Nephrol Hypertens . 2001;10:667–675
  39. Chen SY , Bhargava A , Mastroberardino L , et al.   Epithelial sodium channel regulated by aldosterone-induced protein sgk . Proc Natl Acad Sci U S A . 1999;96:2514–2519
  40. Debonneville C , Flores SY , Kamynina E , et al.   Phosphorylation of Nedd4-2 by sgk1 regulates epithelial Na+ channel cell surface expression . EMBO J . 2001;20:7052–7059
  41. Snyder PM , Olson DR , Thomas BC . Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel . J Biol Chem . 2002;277:5–8
  42. Setiawan I , Henke G , Feng Y . Stimulation of Xenopus oocyte Na(+),K(+)ATPase by the serum and glucocorticoid-dependent kinase sgk1 . Pflugers Arch . 2002;444:426–431
  43. Zecevic M , Heitzmann D , Camargo SMR , et al.   SGK1 increases Na,K-ATPase cell-surface expression and function in Xenopus laevis oocytes . Pflugers Arch . 2004;448:29–35
  44. Wulff P , Vallon V , Huang DY . Impaired renal Na+ retention in the sgk1-knockout mouse . J Clin Invest . 2002;110:1263–1268
  45. Friedrich B , Feng Y , Cohen P , et al.   The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC . Pflugers Arch . 2003;445:693–696
  46. Summa V , Camargo SM , Bauch C , et al.   Isoform specificity of human Na+,K+-ATPase localization and aldosterone regulation in mouse kidney cells . J Physiol (London) . 2003;555:355–365
  47. Hawk CT , Kudo LH , Rouch AJ , et al.   Inhibition by epinephrine of AVP- and cAMP-stimulated Na and water transport in Dahl rat CCD . Am J Physiol . 1993;265:F449–F460
  48. Hawk CT , Li L , Schafer JA . AVP and aldosterone at physiological concentrations have synergistics effects on Na+ transport in rat CCD . Kidney Int . 1996;50:S35–S41
  49. Reif MC , Troutman SL , Schafer JA . Sustained response to vasopressin in isolated rat cortical collecting tubule . Kidney Int . 1984;26:725–732
  50. Reif MC , Troutman SL , Schafer JA . Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone . J Clin Invest . 1986;77:1291–1298
  51. Schafer JA , Troutman SL . cAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin . Am J Physiol . 1990;259:F823–F831
  52. Frindt G , Silver RB , Windhager EE , et al.   Feedback regulation of Na channels in rat CCT. III. Response to cAMP . Am J Physiol . 1995;268:F480–F489
  53. Kleyman TR , Ernst SA , Coupaye-Gerard B . Arginine vasopressin and forskolin regulate apical cell surface expression of epithelial Na channels in A6 cells . Am J Physiol . 1994;266:F506–F511
  54. Djelidi S , Fay M , Cluzeaud F , et al.   Transcriptional regulation of sodium transport by vasopressin in renal cells . J Biol Chem . 1997;272:32919–32924
  55. Ecelbarger CA , Kim GH , Terris J , et al.   Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney . Am J Physiol . 2000;279:F46–F53
  56. Satoh T , Cohen HT , Katz AI . Intracellular signalling in the regulation of renal Na,K-ATPase. I. Role of cyclic cAMP and phospholipase A2 . J Clin Invest . 1992;89:1496–1500
  57. Kiroytcheva M , Cheval L , Carranza ML , et al.   Effect of cAMP on the activity and phosphorylation of Na+,K+-ATPase in rat thick ascending limb of Henle . Kidney Int . 1999;55:1819–1831
  58. Deschenes G , Gonin S , Zolty E , et al.   Increased synthesis and AVP unresponsiveness of Na,K-ATPase in collecting duct from nephrotic rats . J Am Soc Nephrol . 2001;12:2241–2252
  59. Taylor SS , Buechler JA , Yonemoto W . cAMP-dependent protein kinase (Framework for a diverse family of regulatory enzymes) . Annu Rev Biochem . 1990;59:971–1005
  60. Prat AG , Ausiello DA , Cantiello HF . Vasopressin and protein kinase A activate G protein-sensitive epithelial Na channels . Am J Physiol . 1993;265:C218–C223
  61. Prat AG , Bertorello AM , Cantiello HF , et al.   Activation of epithelial Na channels by protein kinase A requires actin filaments . Am J Physiol . 1993;265:C224–C233
  62. Shimkets RA , Lifton R , Canessa CM . In vivo phosphorylation of the epithelial sodium channel . Proc Natl Acad Sci U S A . 1998;95:3301–3305
  63. Carranza ML , Rousselot M , Chibalin AV , et al.   Protein Kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule . J Physiol (London) . 1998;511:235–243
  64. Fisone G , Cheng SX , Nairn AC , et al.   Identification of the phosphorylation site for cAMP-dependent protein kinase on Na(+),K(+)-ATPase and effects of site-directed mutagenesis . J Biol Chem . 1994;269:9368–9373
  65. DeFronzo RA , Cooke CR , Andres R , et al.   The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man . J Clin Invest . 1975;55:845–855
  66. Nizet A , Lefebvre P , Crabbé J . Control by insulin of sodium potassium and water excretion by isolated dog kidney . Pflugers Arch . 1971;323:11–20
  67. Furuya H , Tabei K , Muto S , et al.   Effect of insulin on potassium secretion in rabbit cortical collecting ducts . Am J Physiol . 1992;262:F30–F35
  68. Féraille E , Marsy S , Cheval L , et al.   Sites of antinatriuretic action of insulin along rat nephron . Am J Physiol . 1992;263:F175–F179
  69. Féraille E , Rousselot M , Rajerison R , et al.   Effect of insulin on Na+,K+-ATPase in rat collecting duct . J Physiol (London) . 1995;488:171–180
  70. Marunaka Y , Hagiwara N , Tohda H . Insulin activates single amiloride-blockable Na channels in a distal nephron cell line (A6) . Am J Physiol . 1992;263:F392–F400
  71. Féraille E , Carranza ML , Rousselot M , et al.   Insulin enhances sodium sensitivity of Na,K-ATPase in isolated rat proximal convoluted tubule . Am J Physiol . 1994;267:F55–F62
  72. Féraille E , Carranza ML , Gonin S , et al.   Insulin-induced stimulation of Na+,K+-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the α-subunit at Tyr-10 . Mol Biol Cell . 1999;10:2847–2859
  73. Vinciguerra M , Deschenes G , Hasler U , et al.   Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells . Mol Biol Cell . 2003;14:2677–2688
  74. Zhong H , SuYang H , Erdjument-Bromage H , et al.   The transcriptional activity of NF-kB is regulated by the IkBα-associated PKAc subunit through a cyclic cAMP-independent mechanism . Cell . 1997;89:413–424
  75. Jaisser F , Bugeaon L , Blot-Chabaud M , et al.   Effect of AVP and dDAVP on PGE2 synthesis in superfused cortical collecting ducts . Am J Physiol . 1989;256:F1044–F1050
  76. Cordova HR , Kokko JP , Marver D . Chronic indomethacin increases rabbit cortical collecting tubule Na,K-ATPase activity . Am J Physiol . 1989;256:F570–F576
  77. Sun D , Schafer JA . Dopamine inhibits AVP-dependent Na+ transport and water permeability in rat CCD via a D4-like receptor . Am J Physiol . 1996;271:F391–F400
  78. Li L , Schafer JA . Dopamine inhibits vasopressin-dependent cAMP production in the rat cortical collecting duct . Am J Physiol . 1998;275:F62–F67
  79. Ohbu K , Felder RA . Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension . Am J Physiol . 1993;264:F274–F279
  80. Aperia AC . Intrarenal dopamine (A key signal in the interactive regulation of sodium metabolism) . Annu Rev Physiol . 2000;62:621–647
  81. Takemoto F , Cohen HT , Satoh T , et al.   Dopamine inhibits Na,K-ATPase in single tubules and cultured cells from distal nephron . Pflugers Arch . 1992;421:302–306
  82. Ogimoto G , Yudowski GA , Barker CJ , et al.   G protein-coupled receptors regulate Na,K-ATPase activity and endocytosis by modulating the recruitment of adaptor protein 2 and clathrin . Proc Natl Acad Sci U S A . 2000;97:3242–3247
  83. Efendiev R , Yudowski GA , Zwiller J , et al.   Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na,K-ATPase endocytosis . J Biol Chem . 2002;277:44108–44114
  84. Efendiev R , Budu CE , Cinelli AR , et al.   Intracellular Na+ regulates dopamine and angiotensin II receptor availability at the plasma membrane and their cellular responses in renal epithelia . J Biol Chem . 2003;278:28719–28726
  85. Narkar V , Hussain T , Lokhandwala M . Role of tyrosine kinase and p44/p42 MAPK in D(2)-like receptor-mediated stimulation of Na,K-ATPase in kidney . Am J Physiol . 2002;282:F697–F702
  86. Narkar V , Hussain T , Lokhandwala MF . Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney . Am J Physiol . 2002;283:F1290–F1295
  87. Chen M , Reif MC , Schafer JA . Clonidine and PGE2 have different effects on Na+ and water transport in rat and rabbit CCD . Am J Physiol . 1991;261:F126–F136
  88. Edwards RM , Stack EJ , Pullen M , et al.   Endothelin inhibits vasopressin action in rat inner medullary collecting duct via ETB receptor . J Pharmacol Exp Ther . 1993;267:1028–1033
  89. Chabardès D , Montégut M , Imbert-Teboul M , et al.   Inhibition of α2-adrenergic agonists on AVP-induced cAMP accumulation in isolated collecting tubule of the rat kidney . Mol Cell Endocrinol . 1984;37:263–275
  90. Tomita K , Nonoguchi H , Marumo F . Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat . J Clin Invest . 1990;85:2014–2018

 Supported in part by grant 31-067878.02 from the Swiss National Foundation and by a grant from the Carlos and Elsie de Reuter Foundation (E.F.).

PII: S0270-9295(05)00049-5

doi: 10.1016/j.semnephrol.2005.03.006

Seminars in Nephrology
Volume 25, Issue 5 , Pages 312-321 , September 2005