Seminars in Nephrology
Volume 25, Issue 6 , Pages 388-391 , November 2005

Erythropoietin as a Volume-Regulating Hormone: An Integrated View

  • Karl A. Kirsch

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.
    • Corresponding Author InformationAddress reprints requests to Karl Kirsch, MD, Charité-Universitätsmedizin Berlin, Department of Physiology, Center for Space Medicine, Arnimalle 22, 14195 Berlin, Germany.
  • ,
  • Matthias Schlemmer

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.
  • ,
  • Natale G. De Santo

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.
  • ,
  • Massimo Cirillo

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.
  • ,
  • Alessandra Perna

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.
  • ,
  • Hanns-Christian Gunga

      Affiliations

    • Department of Physiology, Charité-Universitätsmedizin and Center of Space Medicine, Berlin, Germany
    • First Chair of Nephrology, Second University of Naples, Naples, Italy.

References 

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  3. Gauer OH . In: Role of Cardiac Mechanoreceptors in the Control of Plasma Volume . 1978;p. 229–247 “Osmotic and Volume Regulation.” Munksgaard, Alfred Benzon Symposium XI
  4. Lappin TRJ . Classification and consequences of anemia . In:  Jelkmann W editors. Erythropoietin (Molecular Biology and Clinical Use) . Johnson City, TN: E.P. Graham Publishing Co; 2003;
  5. Hochachka PW , Gunga H-C , Kirsch K . Our ancestral physiological phenotype (An adaptation for hypoxia tolerance and for endurance performance?) . Proc Natl Acad Sci U S A . 1998;95:1915–1920
  6. In:  Jelkmann W editors. Erythropoietin (Molecular Biology and Clinical Use) . Johnson City, TN: E.P. Graham Publishing Co; 2003;
  7. Guyton AC , Jones CE , Coleman TG . Circulatory Physiology (Cardiac Output and its Regulation) . Philadelphia: W.B. Saunders; 1973;
  8. Guyton AC , Coleman TG . Longterm regulation of the circulation (Interrelationships with body fluid volumes) . In:  Reeve EB ,  Guyton AC editor. Physical Bases of Circulatory Transport; Regulation and Exchange . Philadelphia: W.B. Saunders; 1967;p. 179–201
  9. McDowell G , Shaw C , Buchanan KD , et al.   The natriuretic peptide family . Eur J Clin Invest . 1995;25:291–298
  10. Epstein M . Renal, endocrine, and hemodynamic effects of water immersion in humans . In:  Fregly MJ ,  Blatteis CM editor. Handbook of Physiology—Environmental Physiology . New York: Oxford University Press; 1996;p. 845–853
  11. Fortney SM , Schneider VS , Greenleaf JE . In: The Physiology of Bed Rest, Handbook of Physiology-Environmental Physiology . New York: Oxford University Press; 1996;p. 889–939
  12. Ameln von H , Laniado M , Röcker L , et al.   Effects of dehydration on the vasopressin response to immersion . J Appl Physiol . 1985;58:114–120
  13. Iwase S , Mano T , Saito M . Effects of graded head-up tilting on muscle sympathetic activities in man . Physiologist . 1987;30:S62–S63
  14. Kamiya A , Iwase S , Kitazawa H , et al.   Baroreflex control of muscle sympathetic nerve activity after 120 days of 6° head-down bed rest . Am J Physiol . 2000;278:R445–R452
  15. Kamiya A , Iwase S , Sugiyama Y , et al.   Vasomotor sympathetic nerve activity in men during bed rest and on orthostasis after bed rest . Aviat Space Environ Med . 2000;71:142–149
  16. Mano T , Iwase S , Saito M , et al.   Somatosensory-vestibular-sympathetic interactions in man under weightlessness simulated by head-out water immersion . In:  Hwang JC ,  Daunton NG ,  Wilson VJ editor. Basic and Applied Aspects of Vestibular Function . Hong Kong: Hong Kong University Press; 1988;
  17. Gunga HC , Kirsch K , Baartz F , et al.   Erythropoietin under real and simulated microgravity conditions in humans . J Appl Physiol . 1996;81:761–773
  18. Gunga HC , Kirsch KA , Roecker L , et al.   Erythropoietin regulation in humans during exercise and in extreme environments . In:  Jelkmann W editors. Erythropoietin (Molecular Biology and Clinical Use) . Johnson City, TN: E.P. Graham Publishing Co; 2003;
  19. Ehmke H , Just A , Eckardt K-U , et al.   Modulation of erythropoietin formation by changes in blood volume in conscious dogs . J Physiol . 1995;488:181–191
  20. Eckardt K-U . Cardiovascular consequences of renal anaemia and erythropoietin therapy . Nephrol Dial Transplant . 1999;14:1317–1323
  21. Heidenreich S , Rahn KH , Zideck W . Erythropoietin induces contraction of isolated renal small resistance vessels . Nephrol Dial Transplant . 1990;5:739–740
  22. Mann JFE . Hypertension and cardiovascular effects—long term safety and potential long-term benefits of r-HuEPO . Nephrol Dial Transplant . 1995;10:80–84
  23. Raine AEG , Roger SD . Effects of erythropoietin on blood pressure . Am J Kidney Dis . 1991;18:76–83
  24. Convertino VA , Mack GW , Nadel ER . Elevated central venous pressure (A consequence of exercise training-induced hypervolemia?) . Am J Physiol . 1991;260:R273–R277
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PII: S0270-9295(05)00102-6

doi: 10.1016/j.semnephrol.2005.05.007

Seminars in Nephrology
Volume 25, Issue 6 , Pages 388-391 , November 2005