Seminars in Nephrology
Volume 26, Issue 2 , Pages 105-113 , March 2006

Acute Renal Failure: Much More Than a Kidney Disease

  • K.J. Kelly

      Affiliations

    • Corresponding Author InformationAddress reprint requests to K. J. Kelly, MD, MSc, Division of Nephrology, Indiana University School of Medicine, 950 West Walnut St, R2-202, Indianapolis, IN 46202.

References 

  1. Bellomo R , Kellum JA , Mehta R , et al.   Acute Dialysis Quality Initiative II (the Vicenza conference) . Curr Opin Crit Care . 2002;8:505–508
  2. Nash K , Hafeez A , Hou S . Hospital-acquired renal insufficiency . Am J Kidney Dis . 2002;39:930–936
  3. Hou SH , Bushinsky DA , Wish JB . Hospital-acquired renal insufficiency (A prospective study) . Am J Med . 1983;74:243–248
  4. Bonventre JV , Weinberg JM . Recent advances in the pathophysiology of ischemic acute renal failure . J Am Soc Nephrol . 2003;14:2199–2210
  5. Schwilk B , Wiedeck H , Stein B , et al.   Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care . Intensive Care Med . 1997;23:1204–1211
  6. Kelly KJ , Molitoris BA . Acute renal failure in the new millennium (Time to consider combination therapy) . Semin Nephrol . 2000;20:4–19
  7. Chertow GM , Lazarus JM , Paganini EP , et al.  The auriculin anaritide acute renal failure study group   Predictors of mortality and the provision of dialysis in patients with acute tubular necrosis . J Am Soc Nephrol . 1998;9:692–698
  8. Brause M , Neumann A , Schumacher T , et al.   Effect of filtration volume of continuous venovenous hemofiltration in the treatment of patients with acute renal failure in intensive care units . Crit Care Med . 2003;31:841–846
  9. Ronco C , Bellomo R , Homel P , et al.   Effects of different doses in continuous veno-venous haemofiltration on outcomes of acute renal failure (A prospective randomised trial) . Lancet . 2000;356:26–30
  10. Benoit DD , Hoste EA , Depuydt PO , et al.   Outcome in critically ill medical patients treated with renal replacement therapy for acute renal failure (Comparison between patients with and those without haematological malignancies) . Nephrol Dial Transplant . 2005;20:552–558
  11. Hoste EA , Lameire NH , Vanholder RC , et al.   Acute renal failure in patients with sepsis in a surgical ICU (Predictive factors, incidence, comorbidity, and outcome) . J Am Soc Nephrol . 2003;14:1022–1030
  12. Mehta RL , McDonald B , Gabbai FB , et al.   A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure . Kidney Int . 2001;60:1154–1163
  13. Jacka MJ , Ivancinova X , Gibney RT . Continuous renal replacement therapy improves renal recovery from acute renal failure . Can J Anaesth . 2005;52:327–332
  14. Groeneveld AB , Tran DD , van der Meulen J , et al.   Acute renal failure in the medical intensive care unit (Predisposing, complicating factors and outcome) . Nephron . 1991;59:602–610
  15. Lien J , Chan V . Risk factors influencing survival in acute renal failure treated by hemodialysis . Arch Intern Med . 1985;145:2067–2069
  16. Lohr J , McFarlane M , Grantham J . A clinical index to predict survival in acute renal failure patients requiring dialysis . Am J Kidney Dis . 1988;11:254–259
  17. Star R . Treatment of acute renal failure . Kidney Int . 1998;54:1817–1831
  18. Chertow G , Christiansen C , Cleary P , et al.   Prognostic stratification in critically ill patients with acute renal failure requiring dialysis . Arch Intern Med . 1995;155:1505–1511
  19. Jorres A , Gahl G , Dobis C , et al.  International Multicentre Study Group   Haemodialysis-membrane biocompatibility and mortality of patients with dialysis-dependent acute renal failure (A prospective randomised multicentre trial) . Lancet . 1999;354:1337–1341
  20. Chertow GM , Levy EM , Hammermeister KE , et al.   Independent association between acute renal failure and mortality following cardiac surgery . Am J Med . 1998;104:343–348
  21. Thakar CV , Worley S , Arrigain S , et al.   Influence of renal dysfunction on mortality after cardiac surgery (Modifying effect of preoperative renal function) . Kidney Int . 2005;67:1112–1119
  22. Koreny M , Karth GD , Geppert A , et al.   Prognosis of patients who develop acute renal failure during the first 24 hours of cardiogenic shock after myocardial infarction . Am J Med . 2002;112:115–119
  23. Hamel M , Phillips R , Davis R , et al.  SUPPORT Investigators   Outcomes and cost-effectiveness of initiating dialysis and continuing aggressive care in seriously ill hospitalized adults . Study to understand prognoses and preferences for outcomes and risks of treatments. Ann Intern Med . 1997;127:195–202
  24. Ryckwaert F , Boccara G , Frappier JM , et al.   Incidence, risk factors, and prognosis of a moderate increase in plasma creatinine early after cardiac surgery . Crit Care Med . 2002;30:1495–1498
  25. Lassnigg A , Schmidlin D , Mouhieddine M , et al.   Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery (A prospective cohort study) . J Am Soc Nephrol . 2004;15:1597–1605
  26. Loef BG , Epema AH , Smilde TD , et al.   Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival . J Am Soc Nephrol . 2005;16:195–200
  27. Gruberg L , Mintz GS , Mehran R , et al.   The prognostic implications of further renal function deterioration within 48h of interventional coronary procedures in patients with pre-existent chronic renal insufficiency . J Am Coll Cardiol . 2000;36:1542–1548
  28. Hirschberg R , Kopple J , Lipsett P , et al.   Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure . Kidney Int . 1999;55:2423–2432
  29. Manns B , Doig CJ , Lee H , et al.   Cost of acute renal failure requiring dialysis in the intensive care unit (Clinical and resource implications of renal recovery) . Crit Care Med . 2003;31:449–455
  30. Basile DP , Donohoe D , Roethe K , et al.   Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function . Am J Physiol . 2001;281:F887–F899
  31. Morgera S , Kraft AK , Siebert G , et al.   Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies . Am J Kidney Dis . 2002;40:275–279
  32. Simmons EM , Himmelfarb J , Sezer MT , et al.   Plasma cytokine levels predict mortality in patients with acute renal failure . Kidney Int . 2004;65:1357–1365
  33. Okusa MD . The inflammatory cascade in acute ischemic renal failure . Nephron . 2002;90:133–138
  34. Hellberg POA , Kallskog OT , Ojteg G , et al.   Peritubular capillary permeability and intravascular RBC aggregation after ischemia (Effects of neutrophils) . Am J Physiol . 1990;258:F1018–F1025
  35. Forbes JM , Hewitson TD , Becker GJ , et al.   Ischemic acute renal failure (Long-term histology of cell and matrix changes in the rat) . Kidney Int . 2000;57:2375–2385
  36. Ysebaert DK , De Greef KE , Vercauteren SR , et al.   Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury . Nephrol Dial Transplant . 2000;15:1562–1574
  37. Linas SL , Whittenburg D , Parsons PE , et al.   Ischemia increases neutrophil retention and worsens acute renal failure (Role of oxygen metabolites and ICAM-1) . Kidney Int . 1995;48:1548–1591
  38. Kielar ML , Rohan Jeyarajah D , Lu CY . The regulation of ischemic acute renal failure by extrarenal organs . Curr Opin Nephrol Hypertens . 2002;11:451–457
  39. Fernandez M , Medina A , Santos F , et al.   Exacerbated inflammatory response induced by insulin-like growth factor I treatment in rats with ischemic acute renal failure . J Am Soc Nephrol . 2001;12:1900–1907
  40. Takala J , Ruokonen E , Webster NR , et al.   Increased mortality associated with growth hormone treatment in critically ill adults . N Engl J Med . 1999;341:785–792
  41. Kelly KJ , Williams WW , Colvin RB , et al.   Intercellular adhesion molecule-1 deficient mice are protected against ischemic renal injury . J Clin Invest . 1996;97:1056–1063
  42. Donnahoo KK , Meng X , Ayala A , et al.   Early kidney TNF-α expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion . Am J Physiol . 1999;277:R922–R929
  43. Serteser M , Koken T , Kahraman A , et al.   Changes in hepatic TNF-α levels, antioxidant status, and oxidation products after renal ischemia/reperfusion injury in mice . J Surg Res . 2002;107:234–240
  44. Kornhauser C , Dubey LA , Garay ME , et al.   Serum and urinary insulin-like growth factor-1 and tumor necrosis factor in neonates with and without acute renal failure . Pediatr Nephrol . 2002;17:332–336
  45. Mizutani A , Okajima K , Uchiba M , et al.   Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation . Blood . 2000;95:3781–3787
  46. Kwon O , Molitoris BA , Pescovitz M , et al.   Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts . Am J Kidney Dis . 2003;41:1074–1087
  47. Kumar S , Boehm J , Lee JC . p38 MAP kinases (Key signalling molecules as therapeutic targets for inflammatory diseases) . Nature Reviews. Drug Discovery . 2003;2:717–726
  48. Zingarelli B , Sheehan M , Wong HR . Nuclear factor-kappaB as a therapeutic target in critical care medicine . Crit Care Med . 2003;31:S105–S111
  49. Solez K , Kramer EC , Heptinstall RH . The pathology of acute renal failure (ARF) (Leukocyte accumulation in the vasa recta) . Am J Pathol . 1974;74:31a
  50. Hakim RM , Wingard RL , Parker RA . Effect of dialysis membrane in the treatment of patients with acute renal failure . N Engl J Med . 1994;331:1338–1342
  51. Springer TA . Traffic signals for lymphocyte recirculation and leukocyte emigration (The multistep paradigm) . Cell . 1994;76:301–314
  52. Kelly KJ , Williams WW , Colvin RB , et al.   Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury . Proc Natl Acad Sci U S A . 1994;91:812–816
  53. Rabb H , Mendiola C , Saba S , et al.   Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury . Biochem Biophys Res Commun . 1995;211:67–73
  54. Haller H , Dragun D , Miethke A , et al.   Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat . Kidney Int . 1996;50:473–480
  55. Azuma H , Nadeau K , Takada M , et al.   Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney . Transplantation . 1997;64:190–197
  56. Blake P , Hasegawa Y , Khosla MC , et al.   Isolation of “myocardial depressant factor(s)” from the ultrafiltrate of heart failure patients with acute renal failure . ASAIO J . 1996;42:M911–M915
  57. Forman MB , Virmani R , Puett DW . Mechanisms and therapy of myocardial reperfusion injury . Circulation . 1990;81:IV69–IV78
  58. Ma X-L , Lefer DJ , Lefer AM , et al.   Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion . Circulation . 1992;86:937–946
  59. Simpson PJ , Todd RF , Fantone JC . Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo-1 and anti-CD11b) that inhibits leukocyte adhesion . J Clin Invest . 1988;81:624–629
  60. Weyrich AS , Ma X-L , Lefer DJ , et al.   In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury . J Clin Invest . 1993;91:2620–2629
  61. Ernst E , Hammerschmidt DE , Bagge U , et al.   Leukocytes and the risk of ischemic diseases . JAMA . 1987;257:2318–2324
  62. Kronon MT , Allen BS , Halldorsson A , et al.   L-arginine, prostaglandin and white cell filtration equally improve myocardial protection in stressed neonatal hearts . J Thorac Cardiovasc Surg . 1999;118:665–672
  63. Kukielka GL , Hawkins HK , Michael L , et al.   Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium . J Clin Invest . 1993;92:1504–1516
  64. Mallick AA , Ishizaka A , Stephens KE , et al.   Multiple organ damage caused by tumor necrosis factor and prevented by prior neutrophil depletion . Chest . 1989;95:1114–1120
  65. Givertz MM , Colucci WS . New targets for heart-failure therapy (Endothelin, inflammatory cytokines, and oxidative stress) . Lancet . 1998;352(suppl 1):S134–S138
  66. Kapadia SR . Cytokines and heart failure . Cardiol Rev . 1999;7:196–206
  67. Recchia FA , Bernstein RD , Sehgal PB , et al.   Cytokines are not a requisite part of the pathophysiology leading to cardiac decompensation . Proc Soc Exp Biol Med . 2000;223:47–52
  68. Levine B , Kalman J , Mayer L , et al.   Elevated circulating levels of tumor necrosis factor in severe chronic heart failure . N Engl J Med . 1990;323:236–241
  69. Aukrust P , Ueland T , Lien E , et al.   Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy . Am J Cardiol . 1999;83:376–382
  70. Deswal A , Peterson NJ , Feldman AM , et al.   Cytokines and cytokine receptors in advanced heart failure (An analysis of the cytokine database from the Vesnarinone Trial (VEST)) . Circulation . 2001;103:2055–2059
  71. Mann DL . Mechanisms and models in heart failure (A combinatorial approach) . Circulation . 1999;100:999–1008
  72. Meldrum D . Tumor necrosis factor in the heart . Am J Physiol . 1998;274:R577–R595
  73. Nian M , Lee P , Khaper N , et al.   Inflammatory cytokines and postmyocardial infarction remodeling . Circ Res . 2004;94:1543–1553
  74. Seta Y , Shan K , Bozkurt B , et al.   Basic mechanisms in heart failure (the cytokine hypothesis) . J Card Fail . 1996;2:243–249
  75. Bozhurt B , Kribbs S , Clubb FJ , et al.   Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats . Circulation . 1998;97:1382–1391
  76. Pagani FD , Baker LS , Hsi C , et al.   Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-α in conscious dogs . J Clin Invest . 1992;90:389–398
  77. Bryant D , Becker L , Richardson J , et al.   Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α . Circulation . 1998;97:1375–1381
  78. Flesch M , Hoper A , Dell’Italia L , et al.   Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor . Circulation . 2003;108:598–604
  79. Edmunds NJ , Lal H , Woodward B . Effects of tumour necrosis factor-α on left ventricular function in the rat isolated perfused heart (Possible mechanisms for a decline in cardiac function) . Br J Pharmacol . 1999;126:189–196
  80. Ono K , Matsumori A , Shioi T , et al.   Cytokine gene expression after myocardial infarction in rat hearts (Possible implication in left ventricular remodeling) . Circulation . 1998;98:149–156
  81. Puhakka M , Magga J , Hietakorpi S , et al.   Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation . J Card Fail . 2003;9:325–332
  82. Momii H , Shimokawa H , Oyama J , et al.   Inhibition of adhesion molecules markedly ameliorates cytokine-induced sustained myocardial dysfunction in dogs in vivo . J Mol Cell Cardiol . 1998;30:2637–2650
  83. Anker SD , Coats AJ . How to RECOVER from RENAISSANCE? . The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH. Int J Cardiol . 2002;86:123–130
  84. Vasan RS , Sullivan LM , Roubenoff R , et al.   Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction (The Framingham Heart Study) . Circulation . 2003;107:1486–1491
  85. Wencker D , Chandra M , Nguyen K , et al.   A mechanistic role for cardiac myocyte apoptosis in heart failure . J Clin Invest . 2003;111:1497–1504
  86. Thornberry NA , Lazebnick Y . Caspases (Enemies within) . Science . 1998;281:1312–1316
  87. Lee P , Sata M , Lefer DJ , et al.   Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo . Am J Physiol . 2003;284:H456–H463
  88. Dbaibo GS , El-Assaad W , Krikorian A , et al.   Ceramide generation by two distinct pathways in tumor necrosis factor α-induced cell death . FEBS Lett . 2001;503:7–12
  89. Daemen MA , van’t Veer C , Denecker G , et al.   Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation . J Clin Invest . 1999;104:541–549
  90. Kang PM , Izumo S . Apoptosis and heart failure (A critical review of the literature) . Circ Res . 2000;86:1107–1113
  91. Olivetti G , Abbi R , Quaini F , et al.   Apoptosis in the failing human heart . N Engl J Med . 1997;336:1131–1141
  92. Narula J , Haider N , Virmani R , et al.   Apoptosis in myocytes in end-stage heart failure . N Engl J Med . 1996;335:1182–1189
  93. Guerra S , Leri A , Wang X , et al.   Myocyte death in the failing human heart is gender dependent . Circ Res . 1999;85:856–866
  94. Saraste A , Pulkki K , Kallajoki M , et al.   Cardiomyocyte apoptosis and progression of heart failure to transplantation . Eur J Clin Invest . 1999;29:380–386
  95. MacLellan WR . Advances in the molecular mechanisms of heart failure . Curr Opin Cardiol . 2000;15:128–135
  96. Yaoita H , Ogawa K , Maehara K , et al.   Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor . Circulation . 1998;97:276–281
  97. Mehta RL , Pascual MT , Soroko S , et al.   Diuretics, mortality and nonrecovery of renal function in acute renal failure . JAMA . 2002;288:2547–2553
  98. Nath KA , Grande JP , Croatt AJ , et al.   Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury . Am J Pathol . 2005;166:963–972
  99. Kramer AA , Postler G , Salhab KF , et al.   Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability . Kidney Int . 1999;55:2362–2367
  100. Deng J , Hu X , Yuen PS , et al.   α-melanocyte-stimulating hormone inhibits lung injury after renal ischemia/reperfusion . Am J Respir Crit Care Med . 2004;169:749–756
  101. Daemen MA , Heemskerk VH , van’t Veer C , et al.   Functional protection by acute phase proteins α1-acid glycoprotein and α1-antitrypsin against ischemia/reperfusion injury by preventing apoptosis and inflammation . Circulation . 2000;102:1420–1426
  102. Ding YF , Zhang XX , Shi GM , et al.   Renal ischemia enhances electrical activity and Fos protein expression of the rostral ventrolateral medullary neurons in rats . Sheng Li Xue Bao . 2001;53:369–374
  103. Sousa VR , Sousa AA , Petroianu A , et al.   Influence of acute renal failure on the mononuclear phagocytic system . Braz J Med Biol Res . 2001;34:1169–1174
  104. Kelly KJ . Distant effects of experimental renal ischemia/reperfusion injury . J Am Soc Nephrol . 2003;14:1549–1558
  105. Kuhar CG , Budihna MV , Pleskovic RZ . Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure . Eur J Pharmacol . 2004;488:137–146
  106. Clark LC , Farghaly H , Saba SR , et al.   Amelioration with vessel dilator of acute tubular necrosis and renal failure established for 2 days . Am J Physiol . 2000;278:H1555–H1564
  107. Nishigaki K , Minatoguchi S , Seishima M , et al.   Plasma Fas ligand, an inducer of apoptosis, and plasma soluble Fas, an inhibitor of apoptosis, in patients with chronic congestive heart failure . J Am Coll Cardiol . 1997;29:1214–1220
  108. Setsuta K , Seino Y , Ogawa T , et al.   Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system . Circ J . 2004;68:747–750
  109. Abbate A , Biondi-Zoccai GG , Bussani R , et al.   Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure . J Am Coll Cardiol . 2003;41:753–760
  110. Patten RD , Denofrio D , El-Zaru M , et al.   Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart . J Am Coll Cardiol . 2005;45:1419–1424
  111. Birks EJ , Latif N , Owen V , et al.   Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices . Circulation . 2001;104:I233–I240
  112. Li Y , Takemura G , Kosai K , et al.   Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure . Circ Res . 2004;95:627–636
  113. Hayakawa Y , Chandra M , Miao W , et al.   Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Gαq transgenic mice . Circulation . 2003;108:3036–3041
  114. Meldrum KK , Meldrum DR , Meng X , et al.   TNF-α-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion . Am J Physiol . 2002;282:H540–H546
  115. Liu Y , Tolbert EM , Lin L , et al.   Up-regulation of hepatocyte growth factor receptor (An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure) . Kidney Int . 1999;55:442–453
  116. Rossman JE , Caty MG , Zheng S , et al.   Mucosal protection from intestinal ischemia-reperfusion reduces oxidant injury to the lung . J Surg Res . 1997;73:41–46
  117. Patel S , Pachter HL , Yee H , et al.   Topical hepatic hypothermia attenuates pulmonary injury after hepatic ischemia and reperfusion . J Am Coll Surg . 2000;191:650–656
  118. Seekamp A , Till GO , Mulligan MS , et al.   Role of selectins in local and remote tissue injury following ischemia and reperfusion . Am J Pathol . 1994;144:592–598
  119. Watanabe A , Kawaharada N , Kusajima K , et al.   Contralateral lung injury associated with single-lung ischemia-reperfusion injury . Ann Thorac Surg . 1996;62:1644–1649
  120. Shin CS , Lee KY , Kim JL , et al.   Renal ischemia-reperfusion injury does not induce pulmonary dysfunction in sheep . Yonsei Med J . 1997;38:142–150
  121. Matsumoto K , Nakamura T . Hepatocyte growth factor (Renotropic role and potential therapeutics for renal diseases) . Kidney Int . 2001;59:2023–2038
  122. Yassin MM , Harkin DW , Barros D’Sa AA , et al.   Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction . World J Surg . 2002;26:115–121
  123. Lawlor DK , Brock RW , Harris KA , et al.   Cytokines contribute to early hepatic parenchymal injury and microvascular dysfunction after bilateral hindlimb ischemia . J Vasc Surg . 1999;30:533–541
  124. Yao YM , Bahrami S , Redl H , et al.   Monoclonal antibody to tumor necrosis factor-alpha attenuates hemodynamic dysfunction secondary to intestinal ischemia/reperfusion in rats . Crit Care Med . 1996;24:1547–1553
  125. Meyer K , Brown MF , Zibari G , et al.   ICAM-1 upregulation in distant tissues after hepatic ischemia/reperfusion (A clue to the mechanism of multiple organ failure) . J Pediatr Surg . 1998;33:350–353
  126. Roux S , Qiu C , Sprecher U , et al.   Protective effects of endothelin receptor antagonists in dogs with aortic cross-clamping . J Cardiovasc Pharmacol . 1999;34:199–205
  127. Allegren RL , Marbury TC , Rahman SN , et al.   Anaritide in acute tubular necrosis . N Engl J Med . 1997;336:828–834
  128. Humes HD , Weitzel WF , Bartlett RH , et al.   Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure . Kidney Int . 2004;66:1578–1588

 Supported in part by National Institutes of Health grant DK02364, the John Bower, MD, Clinical Scientist Award of the National Kidney Foundation, and awards from the American Heart Association Greater Midwest Affiliate (0255226N and 0455664Z).

PII: S0270-9295(05)00184-1

doi: 10.1016/j.semnephrol.2005.09.003

Seminars in Nephrology
Volume 26, Issue 2 , Pages 105-113 , March 2006

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