Seminars in Nephrology
Volume 26, Issue 2 , Pages 158-166 , March 2006

Amino Acid and Protein Kinetics in Renal Failure: An Integrated Approach

References 

  1. Waterlow JC , Garlick PJ , Millward DJ . In: Protein turnover in mammalian tissues and in whole body . New York: Elsevier; 1978;p. 117–176
  2. Miller LL . In: Amino acid pools . Amsterdam: Elsevier; 1961;p. 708–721
  3. Odessey R , Goldberg AL . Oxidation of leucine by rat skeletal muscle . Am J Physiol . 1972;223:1376–1383
  4. Tizianello A , Deferrari G , Garibotto G , et al.   Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency . J Clin Invest . 1980;65:1162–1173
  5. Wahren J , Felig P , Hagenfeldt L . Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus . J Clin Invest . 1976;57:987–999
  6. Garibotto G , Deferrari G , Robaudo C , et al.   Effects of a protein meal on blood amino acid profile in patients with chronic renal failure . Nephron . 1993;64:216–225
  7. Garibotto G , Deferrari G , Robaudo C , et al.   Effect of amino acid ingestion on blood amino acid profile in patients with chronic renal failure . Am J Clin Nutr . 1987;46:949–954
  8. Garibotto G , Deferrari G , Robaudo C , et al.   Disposal of exogenous amino acids by muscle in patients with chronic renal failure . Am J Clin Nutr . 1995;62:136–142
  9. Austin SA , Clemens MJ . The regulation of protein synthesis in mammalian cells by amino acid supply . Biosci Rep . 1981;1:35–44
  10. Lindholm B , Alvestrand A , Furst P , et al.   Plasma and muscle free amino acids during continuous ambulatory peritoneal dialysis . Kidney Int . 1989;35:1219–1226
  11. Raj DSC , Ouwendyk M , Francoeur R , et al.   Serum amino acid profile in nocturnal hemodialysis . Blood Purif . 2000;18:97–102
  12. Bergstrom J , Furst P , Noree LO , et al.   Intracellular free amino acid concentration in human muscle tissue . J Appl Physiol . 1974;36:393–397
  13. Chami J , Reidenberg MM , Wellner D , et al.   Pharmacokinetics of essential amino acids in chronic dialysis patients . Am J Clin Nutr . 1978;31:1652–1659
  14. Lund P , Williamson DH . Inter-tissue nitrogen fluxes . Br Med Bull . 1985;41:251–256
  15. Biolo G , Fleming RY , Maggi SP , et al.   Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle . Am J Physiol . 1995;268:E75–E84
  16. Abumrad NN , Williams P , Frexes-Steed M , et al.   Inter-organ metabolism of amino acids in vivo . Diabetes Metab Rev . 1989;5:213–226
  17. Kominz DR , Hough A , Symonds P , et al.   The amino acid composition of actin, myosin, tropomyosin and meromyosins . Arch Biochem Biophys . 1954;50:148–159
  18. Goldberg AL , Chang TW . Regulation and significance of amino acid metabolism in skeletal muscle . Fed Proc . 1978;37:2301–2307
  19. Raj DSC , Zager P , Shah VO , et al.   Protein turnover and amino acid transport kinetics in end-stage renal disease . Am J Physiol . 2004;286:E136–E143
  20. Raj DSC , Welbourne T , Dominic EA , et al.   Glutamine kinetics and protein turnover in end-stage renal disease . Am J Physiol . 2004;288:E37–E46
  21. Baliga R , George VT , Ray PE , et al.   Effects of reduced renal function and dietary protein on muscle protein synthesis . Kidney Int . 1991;39:831–835
  22. Garber AJ . Skeletal muscle protein and amino acid metabolism in experimental chronic uremia in the rat. Accelerated alanine and glutamine formation and release . J Clin Invest . 1978;62:623–632
  23. Grossman SB , Yap SH , Shafritz DA . Influence of chronic renal failure on protein synthesis and albumin metabolism in rat liver . J Clin Invest . 1977;59:869–878
  24. Goodship TH , Mitch W , Hoer RA , et al.   Adaptation to low protein diets in renal failure (Leucine turnvoer and nitrogen balance) . J Am Soc Nephrol . 1990;1:66–75
  25. Adey D , Kumar R , McCarthy JT , et al.   Reduced synthesis of muscle proteins in chronic renal failure . Am J Physiol . 2000;278:E219–E225
  26. Biolo G , Toigo G , Ciocchi B , et al.   Relationship between whole-body protein turnover and serum creatinine in chronically uremic patients . Miner Electrolyte Metab . 1998;24:267–272
  27. Castellino P , Solini A , Luzi L , et al.   Glucose and amino acid metabolism in chronic renal failure (Effect of insulin and amino acids) . Am J Physiol . 1992;262:F168–F176
  28. Kopple JD , Berg R , Houser H , et al.  Modification of Diet in Renal Disease (MDRD) Study Group   Nutritional status of patients with different levels of chronic renal insufficiency . Kidney Int Suppl . 1989;27:S184–S194
  29. Tom K , Young VR , Chapman T , et al.   Long term adaptive responses to dietary protein restriction in chronic renal failure . Am J Physiol . 1994;4:E668–E677
  30. May RC , Hara Y , Kelly RA , et al.   Branched chain amino acid metabolism in rats muscle (Abnormal regulation in acidosis) . Am J Physiol . 1987;252:E712–E718
  31. Greiber S , Mitch WE . Mechanisms for protein catabolism in uremia (Metabolic acidosis and activation of proteolytic pathways) . Miner Electrolyte Metab . 1992;18:233–236
  32. Collarini EJ , Oxender DL . Mechanisms of transport of amino acids across membranes . Ann Rev Nutr . 1987;7:75–90
  33. Garibotto G , Russo R , Sofia A , et al.   Skeletal muscle protein synthesis and degradation in patients with chronic renal failure . Kidney Int . 1994;45:1432–1439
  34. Graham KA , Reaich D , Channon SM , et al.   Correction of acidosis in CAPD decreases whole body protein degradation . Kidney Int . 1996;49:1396–1400
  35. Graham KA , Reaich D , Channon SM , et al.   Correction of acidosis in hemodialysis decreases whole-body protein degradation . J Am Soc Nephrol . 1997;8:632–637
  36. Guidotti GG , Gazzola GC . Amino acid transporters (Systematic approach and principles of controls) . In:  Kilberg MS ,  Haussinger D editor. Mammalian Amino Acid Transport . New York: Plenum; 1992;p. 9–29
  37. Himmelfarb J , Holbrook D , McMonagle E , et al.   Kt/v, nutritional parameters, serum cortisol, and insulin growth factor-1 levels and patient outcome in hemodialysis . Am J Kidney Dis . 1994;24:473–479
  38. DeFronzo RA , Alvestrand A , Smith D , et al.   Insulin resistance in uremia . J Clin Invest . 1981;67:563–568
  39. Arfvidsson B , Zachrisson H , Moller-Loswick AC , et al.   Effect of systemic hyperinsulinemia on amino acid flux across human legs in postabsorptive state . Am J Physiol . 1991;260:E46–E52
  40. Biolo G , Wolfe RR . Insulin action on protein metabolism . Baillieres Clin Endocrinol Metab . 1993;7:989–1005
  41. Lim VS , Yarasheski KE , Crowley JR , et al.   Insulin is protein-anabolic in chronic renal failure patients . J Am Soc Nephrol . 2003;14:2297–2304
  42. Sapir DG , Pozefsky T , Knochel JP , et al.   The role of alanine and glutamine in steroid-induced nitrogen wasting in man . Clin Sci Mol Med . 1977;53:215–220
  43. Gelfand RA , Matthews DE , Bier DM , et al.   Role of counterregulatory hormones in the catabolic response to stress . J Clin Invest . 1984;74:2238–2248
  44. Sun DF , Zheng Z , Tummala P , et al.   Chronic uremia attenuates growth hormone-induced signal transduction in skeletal muscle . J Am Soc Nephrol . 2004;15:2630–2636
  45. Ding H , Qing DP , Kopple JD . IGF-1 resistance in chronic renal failure (Current evidence and possible mechanisms) . Kidney Int Suppl . 1997;62:S45–S47
  46. Comty CA . Long term dietary management of dialysis patients . J Am Diet Assoc . 1968;54:439–444
  47. Schrimshaw NW . An analysis of past and present recommended daily allowances for protein in health and disease . N Engl J Med . 1976;294:136–142
  48. Kopple JD , Couburn JW . Metabolic studies of low protein diets in uremia. 1. Nitrogen and potassium . Medicine . 1973;52:583–595
  49. Kluthe R , Luttgen FM , Capetianu T , et al.   Protein requirement in maintenance hemodialysis . Am J Clin Nutr . 1978;31:1812–1820
  50. Borah MF , Schoenfeld PY , Gotch FA , et al.   Nitrogen balance during intermittent dialysis therapy of uremia . Kidney Int . 1978;14:491–500
  51. Berkelhammer CH , Baker JP , Leiter LA , et al.   Whole-body protein turnover in adult hemodialysis patients as measured by 13C-leucine . Am J Clin Nutr . 1987;46:778–783
  52. Conley SB , Rose GM , Robson AM , et al.   Effects of dietary intake and hemodialysis on protein turnover in uremic children . Kidney Int . 1980;17:837–846
  53. Lim VS , Yarasheski KE , Flanigan MJ . The effect of uraemia, acidosis, and dialysis treatment on protein metabolism (A longitudinal leucine kinetic study) . Nephrol Dial Transplant . 1998;13:1723–1730
  54. Lim VS , Bier DM , Flanigan MJ , et al.   The effect of hemodialysis on protein metabolism. A leucine kinetic study . J Clin Invest . 1993;91:2429–2436
  55. Ikizler TA , Pupim LB , Brouillette JR , et al.   Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation . Am J Physiol . 2002;282:E107–E116
  56. Raj DSC , Dominic EA , Wolfe RA , et al.   Co-ordinated increase in albumin, fibrinogen and muscle protein synthesis during hemodialysis (Role of cytokines) . Am J Physiol . 2004;286:E658–E664
  57. Kopple JD , Bernard D , Messana J , et al.   Treatment of malnourished CAPD patients with an amino acid based dialysate . Kidney Int . 1995;47:1148–1157
  58. Delarue J , Maingourd C , Objois M , et al.   Effects of an amino acid dialysate on leucine metabolism in continuous ambulatory peritoneal dialysis patients . Kidney Int . 1999;56:1934–1943
  59. Garibotto G , Sofia A , Canepa A , et al.   Acute effects of peritoneal dialysis with dialysates containing dextrose or dextrose and amino acids on muscle protein turnover in patients with chronic renal failure . J Am Soc Nephrol . 2001;12:557–567
  60. Castellino P , Luzi L , Giordano M , et al.   Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients . J Am Soc Nephrol . 1999;10:1050–1058
  61. Flores EA , Bistrian BR , Pomposelli JJ , et al.   Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1 . J Clin Invest . 1989;83:1614–1622
  62. Zamir O , O’Brien W , Thompson R , et al.   Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist . Int J Biochem . 1994;26:943–950
  63. Zamir O , Hasselgren PO , James H , et al.   Effect of tumor necrosis factor or interleukin-1 on muscle amino acid uptake and the role of glucocorticoids . Surg Gynecol Obstet . 1993;177:27–32
  64. Tsujinaka T , Ebisui C , Fujita J , et al.   Muscle undergoes atrophy in association with increase of lysosomal cathepsin activity in interleukin-6 transgenic mouse . Biochem Biophys Res Commun . 1995;207:168–174
  65. Fujita J , Tsujinaka T , Yano M , et al.   Anti-interleukin-6 receptor antibody prevents muscle atrophy in colon-26 adenocarcinoma-bearing mice with modulation of lysosomal and ATP-ubiquitin-dependent proteolytic pathways . Int J Cancer . 1996;68:637–643
  66. Reid MB , Li YP . Tumor necrosis factor-alpha and muscle wasting (A cellular perspective) . Respir Res . 2001;2:269–272
  67. Raj DSC , Dominic EA , Pai A , et al.   Skeletal muscle, cytokines and oxidative stress in End-stage renal disease . Kidney Int . 2005;68:2338–2344
  68. Raj DSC , Shah H , Shah V , et al.   Markers of inflammation, proteolysis and apoptosis in ESRD . Am J Kidney Dis . 2003;42:1212–1220
  69. Castell JV , Gomez-Lechon MJ , David M , et al.   Acute-phase response of human hepatocytes (Regulation of acute-phase protein synthesis by interleukin-6) . Hepatology . 1990;12:1179–1186
  70. Barle H , Januszkiewicz A , Hallstrom L , et al.   Albumin synthesis in humans increases immediately following the administration of endotoxin . Clin Sci . 2002;103:525–531
  71. Biolo G , Fleming RY , Maggi SP , et al.   Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients . J Clin Endocrinol Metab . 2002;87:3378–3384
  72. Pain VM . Initiation of protein synthesis in eukaryotic cells . Eur J Biochem . 1996;236:747–771
  73. Kimball SR , Horetsky RL , Jefferson LS . Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts . Am J Physiol . 1998;274:C221–C228
  74. Graves LM , Bornfeldt KE , Argast GM , et al.   cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells . Proc Natl Acad Sci U S A . 1995;92:7222–7226
  75. Lang CH , Frost RA , Nairn AC , et al.   TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation . Am J Physiol . 2002;282:E336–E347
  76. Kobayashi H , Borsheim E , Anthony TG , et al.   Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B . Am J Physiol . 2003;284:E488–E498
  77. Busquets S , Alvarez B , Lopez-Soriano FJ , et al.   Branched-chain amino acids (A role in skeletal muscle proteolysis in catabolic states?) . J Cell Physiol . 2002;191:283–289
  78. Mitch WE . Robert H Herman Memorial Award in Clinical Nutrition Lecture, 1997. Mechanisms causing loss of lean body mass in kidney disease . Am J Clin Nutr . 1998;67:359–366
  79. Mitch W , Goldberg AL . Mechanisms of muscle wasting. The role of ubiquitin-proteosome pathway . N Engl J Med . 1996;335:1897–1905
  80. Du J , Wang X , Miereles C , et al.   Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions . J Clin Invest . 2004;113:115–123
  81. Lee SW , Dai G , Hu Z , et al.   Regulation of muscle protein degradation (Coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase) . J Am Soc Nephrol . 2004;15:1537–1545
  82. Lecker SH , Jagoe RT , Gilbert A , et al.   Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression . FASEB J . 2004;18:39–51
  83. Shah V , Shah H , Morgan M , et al.   Hemodialysis activates genes regulating inflammation, apoptosis and muscle wasting . J Am Soc Nephrol . 2004;15:618A
  84. Song YH , Li Y , Du J , et al.   Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting . J Clin Invest . 2005;115:451–458
  85. Taylor WE , Bhasin S , Artaza J , et al.   Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells . Am J Physiol . 2001;280:E221–E228
  86. Kopple JD , Swendseid ME , Shinaberger JH , et al.   The free and bound amino acids removed by hemodialysis . Trans Am Soc Artif Int Org . 1973;19:309–313
  87. Ikizler TA , Flakoll PJ , Parker RA , et al.   Amino acid and albumin losses during hemodialysis . Kidney Int . 1994;46:830–837
  88. Biolo G , Tipton KD , Klein S , et al.   An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein . Am J Physiol . 1997;273:E122–E129
  89. Volpi E , Ferrando AA , Yeckel CW , et al.   Exogenous amino acids stimulate net muscle protein synthesis in the elderly . J Clin Invest . 1998;101:2000–2007
  90. Pupim LB , Flakoll PJ , Brouillette JR , et al.   Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients . J Clin Invest . 2002;110:483–492
  91. Saad E , Ferrando A , Oladipo A , et al.   Effect of amino acid replacement during hemodialysis on intracellular amino acid transport and protein turnover . J Am Soc Nephrol . 2003;14:230A
  92. Fryburg DA , Jahn LA , Hill SA , et al.   Insulin and insulin-like growth factor 1 enhance human skeletal muscle protein metabolism during hyperaminoacidemia by different mechanisms . J Clin Invest . 1995;96:1722–1729
  93. Fryburg DA , Barrett EJ . Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans . Metabolism . 1993;42:1223–1227
  94. Biolo G , Declan Fleming RY , Wolfe RR . Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle . J Clin Invest . 1995;95:811–819
  95. Ding H , Gao XL , Hirschberg R , et al.   Impaired actions of insulin-like growth factor 1 on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect . J Clin Invest . 1996;97:1064–1075
  96. Garibotto G , Barreca A , Russo R , et al.   Effects of recombinant human growth hormone on muscle protein turnover in malnourished hemodialysis patients . J Clin Invest . 1997;99:97–105
  97. Fouque D , Peng SC , Shamir E , et al.   Recombinant human insulin-like growth factor-1 induces an anabolic response in malnourished CAPD patients . Kidney Int . 2000;57:646–654
  98. Biolo G , Ciocchi B , Bosutti A , et al.   Pentoxifylline acutely reduces protein catabolism in chronically uremic patients . Am J Kidney Dis . 2002;40:1162–1172
  99. Kimball SR , Horetsky RL , Jefferson LS . Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts . J Biol Chem . 1998;273:30945–30953

PII: S0270-9295(05)00188-9

doi: 10.1016/j.semnephrol.2005.09.006

Seminars in Nephrology
Volume 26, Issue 2 , Pages 158-166 , March 2006

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