Seminars in Nephrology
Volume 26, Issue 2 , Pages 173-181 , March 2006

The Role of Aldosterone in Renal Sodium Transport

  • David J. Rozansky

      Affiliations

    • Corresponding Author InformationAddress reprint requests to David J. Rozansky, MD, PhD, Assistant Professor, Division of Nephrology, Department of Pediatrics, Oregon Health and Science University, Mailcode CDRCP, 3181 Sam Jackson Park Rd, Portland, OR 97239.

References 

  1. Liddle GWBT , Coppage WS . A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion . Trans Am Assoc Phys . 1963;76:199–213
  2. Cheek DB , Perry JW . A salt wasting syndrome in infancy . Arch Dis Child . 1958;33:252–256
  3. Lifton RP , Gharavi AG , Geller DS . Molecular mechanisms of human hypertension . Cell . 2001;104:545–556
  4. Hajjar I , Kotchen TA . Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000 . JAMA . 2003;290:199–206
  5. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents . The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents . Pediatrics . 2004;114:555–576
  6. Wang XY , Masilamani S , Nielsen J , et al.   The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon . J Clin Invest . 2001;108:215–222
  7. Meneton P , Loffing J , Warnock DG . Sodium and potassium handling by the aldosterone-sensitive distal nephron (The pivotal role of the distal and connecting tubule) . Am J Physiol . 2004;287:F593–F601
  8. Halperin ML , Kamel KS . Dynamic interactions between integrative physiology and molecular medicine (The key to understand the mechanism of action of aldosterone in the kidney) . Can J Physiol Pharmacol . 2000;78:587–594
  9. Funder JW , Pearce PT , Smith R , et al.   Mineralocorticoid action (Target tissue specificity is enzyme, not receptor, mediated) . Science . 1988;242:583–585
  10. Struthers AD . Aldosterone blockade in heart failure . J Renin Angiotensin Aldosterone Syst . 2004;5(suppl 1):S23–S27
  11. Pitt B , Zannad F , Remme WJ , et al.  Randomized Aldactone Evaluation Study Investigators   The effect of spironolactone on morbidity and mortality in patients with severe heart failure . N Engl J Med . 1999;341:709–717
  12. Pascual-Le Tallec L , Lombes M . The mineralocorticoid receptor (A journey exploring its diversity and specificity of action) . Mol Endocrinol . 2005;19:2211–2221
  13. Losel R , Schultz A , Wehling M . A quick glance at rapid aldosterone action . Mol Cell Endocrinol . 2004;217:137–141
  14. Mune T , Rogerson FM , Nikkila H , et al.   Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase . Nat Genet . 1995;10:394–399
  15. Sartorato P , Khaldi Y , Lapeyraque AL , et al.   Inactivating mutations of the mineralocorticoid receptor in type I pseudohypoaldosteronism . Mol Cell Endocrinol . 2004;217:119–125
  16. Geller DS , Rodriguez-Soriano J , Vallo Boado A , et al.   Mutations in the mineralocorticoid receptor gene cause autosomal dominant pseudohypoaldosteronism type I . Nat Genet . 1998;19:279–281
  17. Canessa CM , Schild L , Buell G , et al.   Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits . Nature . 1994;367:463–467
  18. Eskandari S , Snyder PM , Kreman M , et al.   Number of subunits comprising the epithelial sodium channel . J Biol Chem . 1999;274:27281–27286
  19. Kellenberger S , Schild L . Epithelial sodium channel/degenerin family of ion channels (A variety of functions for a shared structure) . Physiol Rev . 2002;82:735–767
  20. Shimkets RA , Lifton RP , Canessa CM . The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis . J Biol Chem . 1997;272:25537–25541
  21. Kamynina E , Debonneville C , Bens M , et al.   A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel . FASEB J . 2001;15:204–214
  22. Debonneville C , Flores SY , Kamynina E , et al.   Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression . EMBO J . 2001;20:7052–7059
  23. Shimkets RA , Warnock DG , Bositis CM , et al.   Liddle’s syndrome (Heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel) . Cell . 1994;79:407–414
  24. Alvarez de la Rosa D , Paunescu TG , Els WJ , et al.   Mechanisms of regulation of epithelial sodium channel by SGK1 in A6 cells . J Gen Physiol . 2004;124:395–407
  25. Chang SS , Grunder S , Hanukoglu A , et al.   Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1 . Nat Genet . 1996;12:248–253
  26. Furberg CD , Wright JT , David BR . Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic (The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)) . JAMA . 2002;288:2981–2997
  27. Kim GH , Masilamani S , Turner R , et al.   The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein . Proc Natl Acad Sci U S A . 1998;95:14552–14557
  28. Velazquez H , Bartiss A , Bernstein P , et al.   Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules . Am J Physiol . 1996;270:F211–F219
  29. Masilamani S , Wang X , Kim GH , et al.   Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction . Am J Physiol . 2002;283:F648–F657
  30. Abdallah JG , Schrier RW , Edelstein C , et al.   Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance (Role of aldosterone) . J Am Soc Nephrol . 2001;12:1335–1341
  31. Gitelman HJ , Graham JB , Welt LG . A new familial disorder characterized by hypokalemia and hypomagnesemia . Trans Assoc Am Physicians . 1966;79:221–235
  32. Simon DB , Karet FE , Rodriguez-Soriano J , et al.   Genetic heterogeneity of Bartter’s syndrome revealed by mutations in the K+ channel, ROMK . Nat Genet . 1996;14:152–156
  33. Kunchaparty S , Palcso M , Berkman J , et al.   Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome . Am J Physiol . 1999;277:F643–F649
  34. De Jong JC , Van Der Vliet WA , Van Den Heuvel LP , et al.   Functional expression of mutations in the human NaCl cotransporter (Evidence for impaired routing mechanisms in Gitelman’s syndrome) . J Am Soc Nephrol . 2002;13:1442–1448
  35. Verrey F , Beron J , Spindler B . Corticosteroid regulation of renal Na,K-ATPase . Miner Electrolyte Metab . 1996;22:279–292
  36. Zecevic M , Heitzmann D , Camargo SM , et al.   SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes . Pflugers Arch . 2004;448:29–35
  37. Beron J , Mastroberardino L , Spillmann A , et al.   Aldosterone modulates sodium kinetics of Na,K-ATPase containing an alpha 1 subunit in A6 kidney cell epithelia . Mol Biol Cell . 1995;6:261–271
  38. Stockand JD , Spier BJ , Worrell RT , et al.   Regulation of Na(+) reabsorption by the aldosterone-induced small G protein K-Ras2A . J Biol Chem . 1999;274:35449–35454
  39. Staruschenko A , Patel P , Tong Q , et al.   Ras activates the epithelial Na(+) channel through phosphoinositide 3-OH kinase signaling . J Biol Chem . 2004;279:37771–37778
  40. Naray-Fejes-Toth A , Canessa C , Cleaveland ES , et al.   sgk is an aldosterone-induced kinase in the renal collecting duct. Effects on epithelial na+ channels . J Biol Chem . 1999;274:16973–16978
  41. Chen SY , Bhargava A , Mastroberardino L , et al.   Epithelial sodium channel regulated by aldosterone-induced protein sgk . Proc Natl Acad Sci U S A . 1999;96:2514–2519
  42. Waldegger S , Barth P , Forrest JN , et al.   Cloning of sgk serine-threonine protein kinase from shark rectal gland—a gene induced by hypertonicity and secretagogues . Pflugers Arch . 1998;436:575–580
  43. Rozansky DJ , Wang J , Doan N , et al.   Hypotonic induction of SGK1 and Na+ transport in A6 cells . Am J Physiol . 2002;283:F105–F113
  44. Wang J , Barbry P , Maiyar AC , et al.   SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport . Am J Physiol . 2001;280:F303–F313
  45. Park J , Leong ML , Buse P , et al.   Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway . EMBO J . 1999;18:3024–3033
  46. Zhou R , Snyder PM . Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation . J Biol Chem . 2005;280:4518–4523
  47. Verrey F , Summa V , Heitzmann D , et al.   Short-term aldosterone action on Na,K-ATPase surface expression (Role of aldosterone-induced SGK1?) . Ann N Y Acad Sci . 2003;986:554–561
  48. Summa V , Mordasini D , Roger F , et al.   Short term effect of aldosterone on Na,K-ATPase cell surface expression in kidney collecting duct cells . J Biol Chem . 2001;276:47087–47093
  49. Summa V , Camargo SM , Bauch C , et al.   Isoform specificity of human Na(+), K(+)-ATPase localization and aldosterone regulation in mouse kidney cells . J Physiol . 2004;555:355–364
  50. Wulff P , Vallon V , Huang DY , et al.   Impaired renal Na(+) retention in the sgk1-knockout mouse . J Clin Invest . 2002;110:1263–1268
  51. Wilson FH , Disse-Nicodeme S , Choate KA , et al.   Human hypertension caused by mutations in WNK kinases . Science . 2001;293:1107–1112
  52. Yang CL , Angell J , Mitchell R , et al.   WNK kinases regulate thiazide-sensitive Na-Cl cotransport . J Clin Invest . 2003;111:1039–1045
  53. Kahle KT , Wilson FH , Leng Q , et al.   WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion . Nat Genet . 2003;35:372–376
  54. Kahle KT , Macgregor GG , Wilson FH , et al.   Paracellular Cl- permeability is regulated by WNK4 kinase (Insight into normal physiology and hypertension) . Proc Natl Acad Sci U S A . 2004;101:14877–14882
  55. Yang CL , Zhu X , Wang Z , et al.   Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport . J Clin Invest . 2005;115:1379–1387
  56. O’Reilly M , Marshall E , Speirs HJ , et al.   WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain . J Am Soc Nephrol . 2003;14:2447–2456
  57. Naray-Fejes-Toth A , Snyder PM , Fejes-Toth G . The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport . Proc Natl Acad Sci U S A . 2004;101:17434–17439
  58. Kokubo Y , Kamide K , Inamoto N , et al.   Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population . J Hum Genet . 2004;49:507–515
  59. Kahle KT , Wilson FH , Lifton RP . Regulation of diverse ion transport pathways by WNK4 kinase (A novel molecular switch) . Trends Endocrinol Metab . 2005;16:98–103
  60. Guyton AC . Blood pressure control–special role of the kidneys and body fluids . Science . 1991;252:1813–1816

 Supported in part by grants from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Child Health and Human Development, and the National Kidney Foundation.

PII: S0270-9295(05)00190-7

doi: 10.1016/j.semnephrol.2005.09.008

Seminars in Nephrology
Volume 26, Issue 2 , Pages 173-181 , March 2006

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