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Seminars in Nephrology
Volume 26, Issue 3
, Pages 200-208
, May 2006
Roles of Aquaporins in Kidney Revealed by Transgenic Mice
References
- Aquaporins in the kidney (From molecules to medicine) . Physiol Rev . 2002;82:205–244
- . Clinical update on renal aquaporins . Biol Cell . 2005;97:357–371
-
Renal medullary gene expression in aquaporin-1 null mice
.
Am J Physiol
. 2005;288:F315–F321
- Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice . Biol Cell . 2005;97:765–778
-
.
Analysis of functional organ physiology in transgenic mice
.
Am J Physiol
. 2000;279:C1–C18
- Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels . J Biol Chem . 1998;273:4296–4299
- Nephrogenic diabetes insipidus in mice deficient in aquaporin-3 water channels . Proc Natl Acad Sci U S A . 2000;97:4386–4391
- . Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3 . J Biol Chem . 2001;276:624–628
- Generation and phenotype of a transgenic knock-out mouse lacking the mercurial-insensitive water channel aquaporin-4 . J Clin Invest . 1997;100:957–962
- Early neonatal mortality in a transgenic AQP2 knock-in model of nephrogenic diabetes insipidus . J Biol Chem . 2001;276:2775–2779
-
.
Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion
.
Am J Physiol
. 2006;
in press
- Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice . Proc Natl Acad Sci U S A . 1998;95:9660–9664
-
.
Luminal hypotonicity in proximal tubules of aquaporin-1 knockout mice
.
Am J Physiol
. 2000;278:F1030–F1033
- Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR . Acta Physiol Scand . 2004;181:455–462
- Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice . J Clin Invest . 1999;103:491–496
- Requirement of aquaporin-1 for NaCl driven water transport across descending vasa recta . J Clin Invest . 2000;105:215–222
- Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1 . N Engl J Med . 2001;345:175–179
- Four-fold reduction in water permeability in inner medullary collecting duct of aquaporin-4 knockout mice . Am J Physiol . 1998;274:C549–C554
-
Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues
.
J Cell Sci
. 1995;108:2993–3002
- . The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells . J Biol Chem . 1996;271:4577–4580
-
Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4
.
J Cell Sci
. 1997;110:2855–2860
- Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine . Science . 1994;264:92–95
- . Nephrogenic diabetes insipidus . Annu Rev Physiol . 2001;63:607–630
- Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing . J Clin Invest . 1995;95:2291–2296
- . Misfolding of mutant aquaporin-2 water channels in nephrogenic diabetes insipidus . J Biol Chem . 1999;274:34825–34831
- . Defective trafficking of AQP2 water channels in nephrogenic diabetes insipidus and correction by chemical chaperones . J Clin Invest . 1998;101:2257–2263
- Diabetes insipidus in mice with a mutation in aquaporin-2 . PLoS Genet . 2005;1:e20
-
Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice
.
Am J Physiol
. 2005;289:F1195–F1200
-
Aquaporin-4 is expressed in basolateral membranes of juxtamedullary proximal tubules in mouse kidney
.
Am J Physiol
. 2000;278:F310–F316
-
Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways
.
Am J Physiol
. 2001;281:F1047–F1057
-
Phenotype analysis of aquaporin-8 null mice
.
Am J Physiol
. 2005;288:C1161–C1170
- Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule . Mol Cell Biol . 2005;25:7770–7779
- . Determinants of [Cl-] in recycling and late endosomes and Golgi complex measured using fluorescent ligands . J Cell Biol . 2003;160:1129–1138
- Impairment of angiogenesis and cell migration by targeted of aquaporin-1 gene disruption . Nature . 2005;434:786–792
- Involvement of aquaporin-4 in astroglial cell migration and glial scar formation . J Cell Sci . 2005;118:5691–5698
-
.
Aquaporin-1 facilitates migration of epithelial cells in kidney proximal tubule
.
J Am Soc Nephrol
. 2006;17:38–45
- Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels . J Biol Chem . 1999;274:20071–20074
- . Aquaporin-5 dependent fluid secretion in airway submucosal glands . J Biol Chem . 2001;276:41288–41292
-
Reduced intraventricular pressure and cerebrospinal fluid production in mice lacking aquaporin-1 water channels
.
FASEB J
. 2005;18:76–78
- . Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production . J Gen Physiol . 2002;119:561–569
-
Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
.
Nature Med
. 2000;6:159–163
-
Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema
.
FASEB J
. 2004;18:1291–1293
- Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels . Glia . 2006;53:631–636
- Increased seizure threshold in mice lacking aquaporin-4 water channels . Neuroreport . 2004;15:259–262
- . Impaired hearing in mice lacking aquaporin-4 water channels . J Biol Chem . 2001;276:31233–31237
- In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching . J Neurosci . 2004;24:8049–8056
-
K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator
.
Nature Meth
. 2005;2:825–827
- . Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity and barrier recovery . J Biol Chem . 2002;277:46616–46621
- . Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice . Proc Natl Acad Sci U S A . 2003;100:7360–7365
- Progressive adipocyte hypertrophy in aquaporin-7 deficient mice (Adipocyte glycerol permeability as a novel regulator of fat accumulation) . J Biol Chem . 2005;280:15493–15496
- Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase . Proc Natl Acad Sci U S A . 2005;102:10993–10998
Supported by grants DK35124, DK72517, EY13574, EB00415, HL59198, and HL73856 from the National Institutes of Health, and Research Development Program and Drug Discovery grants from the Cystic Fibrosis Foundation.
PII: S0270-9295(06)00013-1
doi: 10.1016/j.semnephrol.2006.02.002
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 26, Issue 3
, Pages 200-208
, May 2006
