Seminars in Nephrology
Volume 26, Issue 3 , Pages 189-199 , May 2006

Structure-Function Relationships in Aquaporins

  • Melvin E. Laski

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Melvin E. Laski, MD, Professor, Internal Medicine and Physiology, Program Director, Nephrology Fellowship, Texas Tech University Health Sciences Center, 3601 4th St, Lubbock, TX 79430.

References 

  1. Reuss L . General principles of water transport . In:  Seldin DW ,  Giebisch G editor. The Kidney, Physiology and Pathophysiology . (ed 3).. Philadelphia, Lippincott: Williams, and Wilkins; 2000;p. 321–340
  2. In:  Finkelstein A editors. Water Movement Through Lipid Bilayers, Pores, and Plasma Membranes (Theory and Reality) . New York: Wiley; 1987;
  3. Solomon AK . Characterization of biological membranes by equivalent pores . J Gen Physiol . 1968;51(suppl):355S–364S
  4. Brown D , Sabolic I , Breton S . Membrane macro- and microdomains in electrolyte transporting epithelia (structure-function correlations) . In:  Seldin DW ,  Giebisch G editor. The Kidney, Physiology and Pathophysiology (ed 3) . Philadelphia, Lippincott: Williams, and Wilkins; 2000;p. 655–684
  5. Wade JB , Stetson DL , Lewis SA . ADH action (Evidence for a membrane shuttle mechanism) . Ann N Y Acad Sci . 1981;372:106–117
  6. Agre P , Saboori AM , Asimos A , et al.   Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen . J Biol Chem . 1987;262:17497–17503
  7. Smith BL , Agre P . Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins . J Biol Chem . 1991;266:6407–6415
  8. Preston GM , Agre P . Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons (Member of an ancient channel family) . Proc Natl Acad Sci U S A . 1991;88:11110–11114
  9. van Hoek AN , Hom ML , Luthjens LH , et al.   Functional unit of 30 kDa for proximal tubule water channels as revealed by radiation inactivation . J Biol Chem . 1991;266: 16633-1635
  10. Preston GM , Carroll TP , Guggino WB , et al.   Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein . Science . 1992;256:385–387
  11. van Hoek AN , Verkman AS . Functional reconstitution of the isolated erythrocyte water channel CHIP28 . J Biol Chem . 1992;267:18267–18269
  12. Park JH , Saier MH . Phylogenetic characterization of the MIP family of transmembrane channel proteins . J Membr Biol . 1996;153:171–180
  13. Gorin MB , Yancey SB , Cline J , et al.   The major intrinsic protein (MIP) of the bovine lens fiber membrane (Characterization and structure based on cDNA cloning) . Cell . 1984;39:49–59
  14. Chandy G , Zampighi GA , Kreman M , et al.   Comparison of the water transporting properties of MIP and AQP1 . J Membr Biol . 1997;159:29–39
  15. Sabolic I , Valenti G , Verbavetz J-M , et al.   Localization of the CHIP28 water channel in the rat kidney . Am J Physiol . 1993;263:C1225–C1233
  16. Maunsbach AB , Marples D , Chin E , et al.   Aquaporin-1 water channel expression in human kidney . J Am Soc Nephrol . 1997;8:358–360
  17. Nielsen S , Kwon TH , Christensen BM , et al.   Physiology and pathophysiology of renal aquaporins . J Am Soc Nephrol . 1999;92:1013–1017
  18. Sasaki S , Ishibashi K , Marumo F , et al.   Aquaporin-2 and -3 (Representatives of two subgroups of the aquaporin family co-localized in the kidney collecting duct) . Ann Rev Physiol . 1998;60:199–220
  19. Kishore BK , Mandon B , Oza NB , et al.   Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor . J Clin Invest . 1996;97:2763–2771
  20. Saito T , Ishikawa SE , Sasaki S , et al.   Alteration in water channel AQP-2 by removal of AVP stimulation in collecting duct cells of dehydrated rats . Am J Physiol . 1997;272:F183–F191
  21. Echevarria M , Windhager EE , Tate SS , et al.   Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney . Proc Natl Acad Sci U S A . 1994;91:10997–11001
  22. Ishibashi K , Sasaki S , Fushimi K , et al.   Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells . Proc Natl Acad Sci U S A . 1994;91:6269–6273
  23. Terris J , Ecelbarger CA , Marples D , et al.   Distribution of aquaporin-4 water channel expression within rat kidney . Am J Physiol . 1995;269:F663–F672
  24. Matsuzaki T , Suzuki T , Koyama H , et al.   Aquaporin-5 (AQP5) a water channel protein, in the rat salivary and lacrimal glands (Immunolocalization and effect of secretory stimulation) . Cell Tissue Res . 1999;295:513–521
  25. Hibuse T , Maeda N , Funahashi T , et al.   Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase . Proc Natl Acad Sci U S A . 2005;102:10993–10998
  26. Ma T , Yang B , Verkman AS . Cloning of novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart . Biochem Biophys Res Commun . 1997;240:324–328
  27. Ishibashi K , Kuwahara M , Gu Y , et al.   Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol . Biochem Biophys Res Commun . 1998;244:268–274
  28. Ren G , Reddy  , Cheng A , et al.   Visualization of a water-selective pore by electron crystallography in vitreous ice . Proc Natl Acad Sci U S A . 2001;98:1398–1403
  29. Heyman J, Engel A: Aquaporins: Phylogeny, structure, and physiology of water channels. News Physiol Sci 14:187-193
  30. Jung J , Preston G , Smith B , et al.   Molecular structure of the water channel through aquaporin CHIP. The hourglass model . J Biol Chem . 1994;269:14648–14654
  31. Walz T , Hiral T , Murata K , et al.   The 6A three-dimensional structure of aquaporin-1 . Nature . 1997;387:624–627
  32. Cheng A , van Hoek AN , Yeager M , et al.   Three-dimensional organization of a human water channel . Nature . 1997;387:627–630
  33. Verkman AS . More than just water channels (Unespected cellular roles of aquaporins) . J Cell Sci . 2005;118:3225–3232
  34. deGroot BL , Grubmuller H . Water permeation across biological membranes (Mechanism and dynamics of aquaporin-1 and GlpF) . Science . 2001;294:2353–2357
  35. Zeidel ML , Nielsen S , Smith BL , et al.   Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin CHIP in proteoliposomes . Biochemistry . 1994;33:1606–1615
  36. Gouaux E , MacKinnon R . Principles of selective ion transport in channels and pumps . Science . 2005;310:1461–1465
  37. Agre P , Bonhivers M , Borgnia MJ . The aquaporins, blueprints for cellular plumbing systems . J Biol Chem . 1998;273:14659–14662
  38. Nakhoul NL , Davis BA , Romero MF , et al.   Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes . Am J Physiol . 1998;274:C543–C548
  39. Yang B , Fukuda N , van Hoek A , et al.   Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes . J Biol Chem . 2000;275:2686–2692
  40. deGrotthuss CJT . Sur la decomposition de l′eau et des corps qu’elle tient en dissolution a l′aide de l′electricite galvanique . Ann Chim . 1806;LVIII:54–73
  41. Kong Y , Ma J . Dynamic mechanisms of the membrane water channel aquaporin-1 (AQP1) . Proc Natl Acad Sci U S A . 2001;98:14345–14349
  42. Engel A , Fujiyoshi Y , Agre P . The importance of aquaporin water channel protein structure . EMBO J . 2000;19:800–806
  43. Beitz E , Pavlovic-Djuranovic S , Yasui M , et al.   Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis . Proc Acad Sci USA . 2004;101:1153–1158
  44. Fu D , Libson A , Miercke JW , et al.   Structure of a glycerol-conducting channel and the basis for its selectivity . Science . 2000;290:481–486
  45. Tajkhorshid E , Nollert P , Jensen MO , et al.   Control of the selectivity of the aquaporin water channel family by global orientational tuning . Science . 2002;296:525–530
  46. Miloshevsky GV , Jordan PC . Water and ion permeation in bAQP1 and GlpF channels (A kinetic Monte Carlo study) . Biophys J . 2004;87:3690–3702
  47. Jensen MO , Rothlisberger U , Rovira C . Hydroxide and proton migration in aquaporins . Biophys J . 2005;89:1744–1759
  48. Zhu F , Tajkhorshid E , Schulten K . Theory and simulation of water permeation in aquaporin-1 . Biophys J . 2004;86:50–57
  49. Mathai JC , Mori S , Smith GM , et al.   Functional analysis of aquaporin 1 deficient red cells . J Biol Chem . 1996;271:1309–1313
  50. Tajkhorshid E , Schulten K . Winning illustration, National Science Foundation and Science Magazine 2004 Science and Engineering Visualization Challenge . Science . 2004;305:1905
  51. Preston GM , Jung JS , Guggino WB , et al.   The mercury sensitive residue at C189 in the CHIP28 water channel . J Biol Chem . 1991;268:17–20
  52. Liu K , Kozono D , Kato Y , et al.   Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution . Proc Natl Acad Sci U S A . 2005;102:2192–2197
  53. Yasui M , Hazama A , Kwon TH , et al.   Rapid gating and anion permeability of an intracellular aquaporin . Nature . 1999;402:184–187
  54. Ikeda M , Bitz E , Kozono D , et al.   Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63 . J Biol Chem . 2002;277:39873–39879

PII: S0270-9295(06)00029-5

doi: 10.1016/j.semnephrol.2006.03.002

Seminars in Nephrology
Volume 26, Issue 3 , Pages 189-199 , May 2006

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