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Seminars in Nephrology
Volume 26, Issue 5
, Pages 361-374
, September 2006
Kidney Vacuolar H+-ATPase: Physiology and Regulation
References
- . The vacuolar (H+)-ATPases-nature’s most versatile proton pumps. Nat Rev Mol Cell Biol. 2002;3:94–103
- . Structure and properties of the vacuolar (H+)-ATPases. J Biol Chem. 1999;274:12951–12954
- . Structure, function, and cellular distribution of the vacuolar H+-ATPase (HV ATPase/proton pump). In: Seldin DW, Giebisch G editor. The Kidney; Physiology and Pathophysiology. Philadelphia: Lippincott Williams and Wilkins; 2000;p. 171–191
- Genetic and cell biological aspects of the yeast vacuolar H(+)-ATPase. J Bioenerg Biomembr. 1992;24:395–406
- . Structure, mechanism and regulation of the clathrin-coated vesicle and yeast vacuolar H+-ATPases. J Exp Biol. 2000;203:71–80
- Relative roles of Na+/H+ exchange and vacuolar-type H+ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages. J Cell Physiol. 1993;157:453–460
- . The structure and biochemistry of the vacuolar H+-ATPase in proximal and distal urinary acidification. J Bioenerg Biomembr. 1992;24:351–360
- Activation of lysosomal function during dendritic cell maturation. Science. 2003;299:1400–1403
- Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig. Am J Physiol. 2000;279:R1695–R1700
- . Mechanisms of endolymph secretion. Kidney Int. 1998;53(suppl):S98–S103
- Localization of pH regulating proteins H+-ATPase and Cl−/HCO3− exchanger in guinea pig inner ear. Hear Res. 1997;114:21–34
- Proton secretion in the male reproductive tract: Involvement of Cl−-independent HCO3− transport. Am J Physiol. 1998;275:C1134–C1142
- . ATP synthases (Structure, function and evolution of unique energy converters). Cell Mol Life Sci. 2003;60:474–494
- Structure-function relationships of A-, F- and V-ATPases. J Exp Biol. 2001;204:2597–2605
- Renal vacuolar H+-ATPase. Physiol Rev. 2004;84:1263–1314
- . Vacuolar and plasma membrane proton adenosine-triphosphatases. Physiol Rev. 1999;79:361–385
- Revised nomenclature for mammalian vacuolar-type H+-ATPase subunit genes. Mol Cell. 2003;12:801–803
- . Biochemistry and Molecular Biology. In: Brambl R, Marzluf J editor. The Mycota III. Berlin: Springer-Verlag; 1996;p. 57–83
- Site-directed mutagenesis of the yeast V-ATPase A subunit. J Biol Chem. 1997;272:11750–11756
- Mutational analysis of the nucleotide binding sites of the yeast vacuolar proton-translocating ATPase. J Biol Chem. 1998;273:150–156
- . 3′-O-(4-Benzoyl)benzoyladenosine 5′-triphosphate inhibits activity of the vacuolar (H+)-ATPase from bovine brain clathrin-coated vesicles by modification of a rapidly exchangeable, noncatalytic nucleotide binding site on the B subunit. J Biol Chem. 1996;271:12775–12782
- . Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. J Biol Chem. 1987;262:15780–15789
- Heterogeneity of vacuolar H+-ATPase differential expression of two human subunit B isoforms. Biochem J. 1994;303:191–198
- Selectively amplified expression of an isoform of the vacuolar H+-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992;89:3541–3545
- The B1 subunit of the H+ATPase is a PDZ domain-binding protein (Colocalization with NHE-RF in renal B-intercalated cells). J Biol Chem. 2000;275:18219–18224
- . Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J Med Genet. 2002;39:796–803
- . Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans (A new gene, vha-3, has a distinct cell-specific distribution). J Biol Chem. 1998;273:22570–22576
- . Bafilomycins a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc Natl Acad Sci U S A. 1988;85:7972–7976
- . Mutations in subunit c of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. J Biol Chem. 2002;277:3965–3972
- . Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps. J Biol Chem. 1994;269:17379–17381
- . Subunit a of the yeast V-ATPase participates in binding of bafilomycin. J Biol Chem. 2005;280:40481–40488
- VMA11 and VMA16 encode second and third proteolipid subunits of the Saccharomyces cerevisiae vacuolar membrane H+-ATPase. J Biol Chem. 1997;272:4795–4803
- . Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation. J Biol Chem. 2001;276:17941–17948
- Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Nat Genet. 2000;26:71–75
- Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis. Nat Genet. 2000;25:343–346
- Molecular cloning and characterization of Atp6n1b a novel fourth murine vacuolar H+-ATPase a-subunit gene. J Biol Chem. 2001;276:42382–42388
- . Transmembrane topography of the 100-kDa a subunit (Vph1p) of the yeast vacuolar proton-translocating ATPase. J Biol Chem. 1999;274:14655–14661
- . Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase. J Biol Chem. 2000;275:6824–6830
- . Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C (G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis). Gene. 2002;297:169–177
- Vacuolar H+-ATPase d2 subunit: molecular characterization, developmental regulation, and localization to specialized proton pumps in kidney and bone. J Am Soc Nephrol. 2005;5:1245–1256
- . Expression and function of the mouse V-ATPase d subunit isoforms. J Biol Chem. 2003;278:46396–46402
- . ATP synthase’s second stalk comes into focus. Nature. 1998;393:29
- . Structure of the vacuolar ATPase by electron microscopy. J Biol Chem. 1999;274:31804–31810
- Evidence for rotation of V1-ATPase. Proc Natl Acad Sci U S A. 2003;100:2312–2315
- Subunit rotation of vacuolar-type proton pumping ATPase relative rotation of the G and C subunits. J Biol Chem. 2003;278:23714–23719
- Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase. Proc Natl Acad Sci U S A. 2004;101:59–64
- Mutational analysis of the subunit C (Vma5p) of the yeast vacuolar H+-ATPase. J Biol Chem. 2002;277:8979–8988
- . Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo. J Biol Chem. 1995;270:17025–17032
- Regulation of plasma membrane V-ATPase activity by dissociation of peripheral subunits. J Biol Chem. 1995;270:5649–5653
- . Cysteine-mediated cross-linking indicates that subunit C of the V-ATPase is in close proximity to subunits E and G of the V1 domain and subunit a of the Vo domain. J Biol Chem. 1995;280:27896–27903
- Evidence that the NH2 terminus of vph1p, an integral subunit of the V0 sector of the yeast V-ATPase, interacts directly with the Vma1p and Vma13p subunits of the V1 sector. J Biol Chem. 2000;275:15449–15457
- Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary. Eur J Biochem. 1999;262:484–491
- Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005;16:3235–3256
- . Cellular mechanisms of renal tubular acidification. In: Seldin DW, Giebisch G editor. The Kidney Physiology and Pathophysiology. (ed 3).. Philadelphia: Lippincott Williams & Wilkins; 2000;p. 1935–1979
- Biochemical aspects of H+-ATPase in renal proximal tubules: Inhibition by N, N′-dicyclohexylcarbodiimide, N-ethylmaleimide, and bafilomycin. Kidney Int Suppl. 1991;33:S64–S70
- . Characteristics of the proton pump in rat renal cortical endocytotic vesicles. Am J Physiol. 1986;250:F817–F826
- . Localization of a proton-pumping ATPase in rat kidney. J Clin Invest. 1988;82:2114–2126
- Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis. Am J Physiol. 2004;287:C149–C162
- Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem. 1992;267:9948–9957
- Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest. 2000;105:1141–1146
- Bicarbonate reabsorption and NHE-3 expression abundance and activity are increased in Henle’s loop of remnant rats. Kidney Int. 2002;62:2126–2135
- Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol. 1997;273:F601–F614
- Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991;88:126–136
- Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989;86:5429–5433
- Localization of pendrin in mouse kidney. Am J Physiol. 2002;284:F229–F241
- A new member of the HCO3− transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney. J Biol Chem. 2001;276:8180–8189
- . Genetic diseases of acid-base transporters. Annu Rev Physiol. 2002;64:899–923
- Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Am J Physiol. 2003;284:F584–F593
- . Transport characteristics of the apical anion exchanger of rabbit cortical collecting duct beta-cells. Am J Physiol. 1999;276:F635–F643
- Regulation of the expression of the Cl−/anion exchanger pendrin in mouse kidney by acid-base status. Kidney Int. 2002;62:2109–2117
- Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001;98:4221–4226
- . Prolactin regulation of the pendrin-iodide transporter in the mammary gland. Am J Physiol. 2003;284:E25–E28
- . Recent advances in our understanding of intercalated cells. Curr Opin Nephrol Hypertens. 2005;14:480–488
- . Contribution of the Na+-K+-2 CL−cotransporter (NKCC1) to transepithelial transport of H+, NH4+, K+, and Na+ in rat outer medullary collecting duct. J Am Soc Nephrol. 2002;13:827–835
- Differential regulation of basolateral Cl−/HCO3− exchangers Slc26a7 and AE1 in kidney outer medullary collecting duct. J Am Soc Nephrol. 2004;15:2002–2011
- . Roles and mechanisms of urinary buffer excretion. Am J Physiol. 1987;253:F595–F605
- . Luminal acidification in K-replete OMCDi: contributions of H+-K+-ATPase and bafilomycin-A1-sensitive H-ATPase. Am J Physiol. 1994;267:F450–F458
- Morphologic heterogeneity along the rat inner medullary collecting duct. Lab Invest. 1989;60:219–230
- . Proton gradient formation in early endosomes from proximal tubules. Biochim Biophys Acta. 1996;1284:171–180
- . H+ extrusion by an apical vacuolar-type H+-ATPase in rat renal proximal tubules. J Membr Biol. 1992;126:19–26
- Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells. Proc Natl Acad Sci U S A. 1998;95:9665–9668
- . Cell pH and H+ secretion by S3 segment of mammalian kidney role of H+-ATPase and Cl−. J Membr Biol. 2000;178:115–125
- Role of Cl− in electrogenic H+ secretion by cortical distal tubule. J Membr Biol. 1997;157:193–201
- The intrinsic Cl− conductance of mouse kidney cortex brush-border membrane vesicles is not related to CFTR. Pflugers Arch. 1997;434:575–580
- Properties of chloride-conductive pathways in rat kidney cortical and outer-medulla brush-border membranes—inhibition by anti-(cystic fibrosis transmembrane regulator) mAbs. Eur J Biochem. 1997;246:367–372
- . Protein kinase A regulates chloride conductance in endocytic vesicles from proximal tubule. Nature. 1990;348:637–639
- Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. Cell. 1999;96:495–506
- An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol. 1996;133:29–41
- Assembly of distinctive coated pit and microvillar microdomains in the renal brush border. Am J Physiol. 1992;262:F55–F67
- . SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol. 2001;2:98–106
- Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as q- and r-SNAREs. Proc Natl Acad Sci U S A. 1998;95:15781–15786
- SNARE proteins regulate H+-ATPase redistribution to the apical membrane in rat renal inner medullary collecting duct cells. J Biol Chem. 1999;274:26518–26522
- . Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. J Biol Chem. 2003;278:19791–19797
- Vacuole membrane fusion: V0 functions after trans-SNARE pairing and is coupled to the Ca2+-releasing channel. J Cell Biol. 2003;162:211–222
- Selectively amplified expression of an isoform of the vacuolar H+-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992;89:3541–3545
- Differential expression of the “B” subunit of the vacuolar H+-ATPase in bovine tissues. J Biol Chem. 1992;267:3696–3706
- The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction. Am J Physiol. 2003;284:C667–C673
- . A novel role for subunit C in mediating binding of the H+-V-ATPase to the actin cytoskeleton. J Biol Chem. 2003;278:18499–18505
- . Plasticity of functional epithelial polarity. Nature. 1985;318:368–371
- Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. Clin Invest. 2002;109:89–99
- . Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. J Clin Invest. 1996;98:2324–2331
- . Role of hensin in mediating the adaptation of the cortical collecting duct to metabolic acidosis. Curr Opin Nephrol Hypertens. 2005;14:383–388
- Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J Clin Invest. 2002;109:89–99
- Galectin-3 expression is induced in renal beta-intercalated cells during metabolic acidosis. Am J Physiol. 2006;290:F148–F158
- . Cellular remodeling of HCO3−-secreting cells in rabbit renal collecting duct in response to an acidic environment. J Cell Biol. 1989;109:1279–1288
- Effect of respiratory acidosis and respiratory alkalosis on renal transport enzymes. Am J Physiol. 1994;267:F390–F399
- . Carbonic anhydrase II and IV mRNA in rabbit nephron segments: Stimulation during metabolic acidosis. Am J Physiol. 1998;274:F259–F267
- . Colchicine-induced redistribution of proton pumps in kidney epithelial cells. Kidney Int Suppl. 1991;33:S79–S83
- Effect of metabolic acidosis and alkalosis on NEM-sensitive ATPase in rat nephron segments. Am J Physiol. 1992;262:F583–F590
- . Potassium deprivation upregulates expression of renal basolateral Na+-HCO3− cotransporter (NBC-1). Am J Physiol. 2000;279:F532–F543
- . Morphometric analysis of kidney hypertrophy in rats after chronic potassium depletion. Am J Physiol. 1992;262:F656–F667
- The relationship between distal tubular proton secretion and dietary potassium depletion: Evidence for up-regulation of H+-ATPase. Nephrol Dial Transplant. 1999;14:1435–1440
- . Localization and function of angiotensin AT1 receptors. Am J Hypertens. 2000;13:31S–38S
- Immortalized rabbit cortical collecting duct cells express AT1 angiotensin II receptors. Am J Physiol. 1996;271:F1147–F1157
- Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol. 1999;10:S189–S195
- . Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. Am J Physiol. 1996;271:F143–F149
- . Stimulation of H+-ATPase in intercalated cells from isolated mouse cortical collecting ducts by angiotensin II. J Am Soc Nephrol. 2000;11:A0054;(abstr)
- Surviving rat distal tubule bicarbonate reabsorption: Effects of chronic AT1 blockade. Am J Physiol. 2000;278:F476–F483
- Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron. J Am Soc Nephrol. 1997;8:1658–1666
- Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II. Am J Physiol. 1995;269:F730–F738
- . Acid-base transport in the collecting duct. J Nephrol. 2002;15:S112–S127
- Angiotensin II increases H+-ATPase B1 subunit expression in medullary collecting ducts. Hypertension. 2005;45:818–823
- . Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro. Am J Physiol. 1978;235:F576–F585
- Mineralocorticoid modulation of rabbit medullary collecting duct acidification (A sodium-independent effect). J Clin Invest. 1983;72:77–83
- . Effects of aldosterone on NEM-sensitive ATPase in rabbit nephron segments. Kidney Int. 1988;34:13–17
- . Early aldosterone action: Toward filling the gap between transcription and transport. Am J Physiol. 1999;277:F319–F327
- Aldosterone increases the synthesis and cell surface expression of a4, a kidney specific subunit of H+-ATPase in a mouse renal collecting tubule cell line. J Am Soc Nephrol. 2003;14:68
- Early genomic effect of aldosterone on a4 subunit of the vacuolar H+-ATPase. J Am Soc Nephrol. 2005;16:F-PO002
- . Regulation of collecting tubule adenosine triphosphates by aldosterone and potassium. J Clin Invest. 1993;91:2385–2392
- Nongenomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone. Proc Natl Acad Sci U S A. 2004;101:2636–2641
- . Renal tubular acidosis. In: Scriver CR, Beaudet AL, Sly WS editor. The Metabolic and Molecular Bases of Inherited Disease. (ed 8).. New York: McGraw-Hill; 2001;p. 4983–5021
- . Renal tubular acidosis: the clinical entity. J Am Soc Nephrol. 2002;13:2160–2170
- Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet. 1999;21:84–90
- Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34. Am J Hum Genet. 1999;65:1656–1665
- The primary hereditary form of distal renal tubular acidosis: Clinical and genetic studies in a 60-member kindred. Clin Genet. 1994;45:194–199
- Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc Natl Acad Sci U S A. 1998;95:6337–6342
- Generation and characterization of H+-ATPase B1 subunit deficient mice. J Am Soc Nephrol. 2001;12:0015;(abstr)
- Loss of plasma membrane H+-ATPase activity from cortical collecting duct intercalated cells of H+-ATPase B1-subunit deficient mice: A mouse model of distal renal tubular acidosis. J Am Soc Nephrol. 2002;13:0004;(abstr)
- . Proton translocation driven by ATP hydrolysis in V-ATPases. FEBS Lett. 2003;545:76–85
- A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse. Pflugers Arch. 2003;446:623–632
PII: S0270-9295(06)00081-7
doi: 10.1016/j.semnephrol.2006.07.004
© 2006 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 26, Issue 5
, Pages 361-374
, September 2006
