Seminars in Nephrology
Volume 27, Issue 2 , Pages 161-171, March 2007

Angiogenesis in Diabetic Nephropathy

  • Roy Zent, MD, PhD
    • ,
  • Ambra Pozzi, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ambra Pozzi, PhD, Department of Medicine, Division of Nephrology, Vanderbilt University, Medical Center North, B3109, Nashville, TN, 37232.

Department of Research Medicine, Veterans Affairs Hospital, Nashville, TN, and Department of Medicine, Division of Nephrology, Medical Center North, Vanderbilt University, Nashville, TN.

Summary 

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a key role in both physiologic and pathologic events, including wound healing, cancer, and diabetes. Neovascularization has been implicated in the genesis of diverse diabetic complications such as retinopathy, impaired wound healing, neuropathy, and, most recently, diabetic nephropathy. Diabetic nephropathy is one of the major microvascular-associated complications in diabetes and is the leading cause of end-stage renal disease worldwide. In this review we describe the major factors involved in the pathologic glomerular microvascular alterations in response to hyperglycemia and the possible use of anti-angiogenic therapies for the treatment of diabetic nephropathy.

Keywords: Angiogenesis, diabetes, kidney, therapy, endothelial cells

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 Supported in part by National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants R01-DK074359 (A.P.); RO1-DK 69921 (R.Z.), National Institutes of Health/NIDDK O’Brien Center grant P50-DK39261-16 (A.P., R.Z.), and a Merit award from the Department of Veterans Affairs (R.Z.).

PII: S0270-9295(07)00008-3

doi:10.1016/j.semnephrol.2007.01.007

Seminars in Nephrology
Volume 27, Issue 2 , Pages 161-171, March 2007

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