Seminars in Nephrology
Volume 27, Issue 2 , Pages 153-160, March 2007

Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

  • Yanqing Zhu, MD
    • ,
  • Hitomi Kataoka Usui, MD, PhD
    • ,
  • Kumar Sharma, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Kumar Sharma, MD, Thomas Jefferson University, Suite 353, Jefferson Alumni Hall, 1020 Locust St, Philadelphia, PA 19107.

Center for Novel Therapies in Kidney Disease, Dorrance Hamilton Research Laboratories, Division of Nephrology, Thomas Jefferson University, Philadelphia, PA.

Summary

The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

Keywords: Protein kinase C, reactive oxygen species, upstream stimulatory factor, HETE, decorin, thrombospondin, macrophages, podocytes, glucose excursion

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 Supported by the National Institutes of Health (R01DK053867-07, R01DK063017-04, U01DK076133-02 to K.S.), the American Diabetes Association, and the Juvenile Diabetes Research Foundation.

PII: S0270-9295(07)00009-5

doi:10.1016/j.semnephrol.2007.01.008

Seminars in Nephrology
Volume 27, Issue 2 , Pages 153-160, March 2007

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