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Seminars in Nephrology
Volume 27, Issue 2
, Pages 144-152
, March 2007
The Renin-Angiotensin System and Diabetic Nephropathy
References
- . Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev. 1977;57:313–370
- Pressure dependent modulation of renin release in isolated perfused glomeruli. Kidney Int. 1992;41:275–280
- Biomechanical coupling in renin-releasing cells. J Clin Invest. 1997;100:1566–1574
- Macula densa cell signaling involves ATP release through a maxi anion channel. Proc Natl Acad Sci U S A. 2003;100:4322–4327
- Effects of adenosine and angiotensin on macula densa-stimulated renin secretion. Am J Physiol. 1993;265:F187–F194
- Uptake and proteolytic activation of prorenin by cultured human endothelial cells. J Hypertens. 1999;17:621–629
- Proteolytic release of human angiotensin-converting enzyme (Localization of the cleavage site). J Biol Chem. 1993;268:26428–26434
- . Kallikreins and kinins (Molecular characteristics and cellular and tissue responses). Diabetes. 1996;45(Suppl 1):S14–S19
- Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N Engl J Med. 1998;339:1285–1292
- Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993;45:205–251
- . Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. Cold Spring Harb Symp Quant Biol. 2002;67:451–457
- Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci U S A. 1997;94:6391–6396
- . Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature. 1995;377:748–750
- Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 1998;101:527–535
- . Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int. 1981;19:410–415
- Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proc Natl Acad Sci U S A. 1985;82:5963–5967
- Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest. 1986;77:1925–1930
- Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1985;76:612–619
- Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A. 1993;90:1814–1818
- Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest. 1994;93:2431–2437
- Expression of transforming growth factor-beta isoforms in human glomerular diseases. Kidney Int. 1996;49:461–469
- TGF-beta isoforms in renal fibrogenesis. Kidney Int. 2003;64:844–856
- . Renal expression of fibrotic matrix proteins and of transforming growth factor-β (TGF-β) isoforms in TGF-β transgenic mice. J Am Soc Nephrol. 1999;10:271–280
- The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med. 1993;329:1456–1462
- Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001;345:861–869
- Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345:851–860
- The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001;345:870–878
- . USRDS 2006 annual data report (atlas of end-stage renal disease in the United States). Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006;
- Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1990;33:438–443
- . Diabetic renal disease: racial and ethnic differences from an epidemiologic perspective. Transplant Proc. 1993;25:2426–2430
- . Genetics of diabetic nephropathy: evidence for major and minor gene effects. Kidney Int. 1999;55:1582–1596
- An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343–1346
- Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse. Proc Natl Acad Sci U S A. 2001;98:13330–13334
- Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. Endocrinology. 2003;144:2184–2190
- Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proc Natl Acad Sci U S A. 2004;101:13302–13305
- A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87:E1–E9
- A human homolog of angiotensin-converting enzyme (Cloning and functional expression as a captopril-insensitive carboxypeptidase). J Biol Chem. 2000;275:33238–33243
- Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem. 2002;277:14838–14843
- Angiotensin-(1-7): a new hormone of the angiotensin system. Hypertension. 1991;18:126–133
- Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A. 2003;100:8258–8263
- . Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol. 2005;289:H2281–H2290
- Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828
- Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006;47:718–726
- Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006;116:2218–2225
- Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J Biol Chem. 2001;276:17132–17139
- Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. Am J Physiol. Epub. 2006;Accession number: 16985211
- Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension. 2003;41:392–397
- Increased ACE2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination. Hypertension. 2004;43:1120–1125
- ACE and ACE2 activity in diabetic mice. Diabetes. 2006;55:2132–2139
- Renin regulation in type II diabetes mellitus: influence of dietary sodium. Hypertension. 1989;13:200–205
- . Hyporeninemic hypoaldosteronism in diabetes mellitus (Studies of the autonomic nervous system’s control of rennin release). Diabetes. 1979;28:237–241
- . Plasma rennin activity in diabetes mellitus. Clin Sci (Lond). 1979;56:255–259
- . Increased glomerular filtration rate as a predictor of diabetic nephropathy: an 8-year prospective study. Kidney Int. 1992;41:822
- . Physiology of local renin-angiotensin systems. Physiol Rev. 2006;86:747–803
- . Renal renin-angiotensin system in diabetes: functional, immunohistochemical and molecular biological correlations. Am J Physiol. 1993;265:4777–4786
- Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest. 1992;90:766–771
- Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest. 1996;98:1991–2000
- Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy. Kidney Int. 1997;51:57–68
- Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int. 2004;65:30–39
- Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II. Diabetes. 2003;52:1023–1030
- Irbesartan normalizes the deficiency in glomerular nephrin expression in a model of diabetes and hypertension. Diabetologia. 2001;44:874–877
- Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition. Diabetologia. 2002;45:1572–1576
- Comparative effects of ramipril on ambulatory and office blood pressures (A HOPE substudy). Hypertension. 2001;38:e28
- Renoprotection by ACE inhibition or aldosterone blockade is blood pressure–dependent. Hypertension. 2003;41:201–206
- Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2005;16:27–45
Supported in part by grants from the National Institutes of Health (5 U01 HL070523-05), the American Heart Association, and the US Department of Veterans Affairs.
PII: S0270-9295(07)00010-1
doi: 10.1016/j.semnephrol.2007.01.009
© 2007 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 27, Issue 2
, Pages 144-152
, March 2007
