Seminars in Nephrology
Volume 27, Issue 5 , Pages 524-528 , September 2007

The (Pro)Renin Receptor and the Kidney

References 

  1. Ichihara A, Hayashi M, Kaneshiro Y, et al. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for non-proteolytic activation of prorenin. J Clin Invest. 2004;114:1128–1135
  2. Nguyen G, Delarue F, Burckle C, et al. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417–1427
  3. Schefe JH, Funke-Kaiser H, Jost A, et al. Signal transduction of the renin/prorenin receptor. [abstract] J Hypertens. 2005;23(Suppl 2):S354
  4. Huang Y, Wongamorntham S, Kasting J, et al. Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int. 2006;69:105–113
  5. Ichihara A, Suzuki F, Nakagawa T, et al. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol. 2006;17:1950–1961
  6. Suzuki F, Hayakawa M, Nakagawa T, et al. Human prorenin has “gate and handle” regions for its non-proteolytic activation. J Biol Chem. 2003;278:22217–22222
  7. Nabi AHMN, Kageshima A, Uddin M, et al. Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med. 2006;18:483–488
  8. Hamming I, Contrepas A, Nguyen G, et al. Regulation of the renal renin/(pro)renin receptor (RPR) by ACE inhibition and sodium restriction. [abstract] J Am Soc Nephrol. 2005;16:120A
  9. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003;83:253–307
  10. Khan KN, Stanfield KM, Harris RK, et al. Expression of cyclooxygenase-2 in the macula densa of human kidney in hypertension, congestive heart failure, and diabetic nephropathy. Ren Fail. 2001;23:321–330
  11. Komers R, Lindsley JN, Oyama TT, et al. Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. J Clin Invest. 2001;107:889–898
  12. Kaneshiro Y, Ichihara A, Takemitsu T, et al. Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int. 2006;70:641–646
  13. Obata J, Nakamura T, Takano H, et al. Increased gene expression of components of the renin-angiotensin system in glomeruli of genetically hypertensive rats. J Hypertens. 2000;18:1247–1255
  14. Ichihara A, Kaneshiro Y, Takemitsu T, et al. Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894–900
  15. Veniant M, Menard J, Bruneval P, et al. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest. 1996;98:1966–1970
  16. Ichihara A, Kaneshiro Y, Takemitsu T, et al. Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol. 2006;17:2495–2503

 Supported in part by grants from the Ministry of Education, Science and Culture of Japan (16790474 and 17390249).

PII: S0270-9295(07)00090-3

doi: 10.1016/j.semnephrol.2007.07.005

Seminars in Nephrology
Volume 27, Issue 5 , Pages 524-528 , September 2007

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