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Seminars in Nephrology
Volume 27, Issue 5
, Pages 529-537
, September 2007
The Association of Aldosterone With Obesity-Related Hypertension and the Metabolic Syndrome
References
- . Multiple mechanisms involved in obesity-induced hypertension. Heart Lung Circ. 2003;12:84–93
- . The metabolic syndrome. Lancet. 2005;365:1415–1428
- Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112:2735–2752
- . The metabolic syndrome—a new worldwide definition. Lancet. 2005;366:1059–1062
- The disease burden associated with overweight and obesity. JAMA. 1999;282:1523–1529
- Body mass index and blood pressure in Korean men and women: the Korean National Blood Pressure Survey. J Hypertens. 1994;12:1433–1437
- Pathogenesis of weight-related changes in blood pressure in dogs. Hypertension. 1989;13:922–928
- . Aldosterone in obesity. Endocr Res. 1998;24:789–796
- Weight loss and the renin-angiotensin-aldosterone system. Hypertension. 2005;45:356–362
- The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients. N Engl J Med. 1981;304:930–933
- Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42:878–884
- Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med. 1987;16:235–251
- Mortality and cardiac and vascular outcomes in extremely obese women. JAMA. 2006;296:79–86
- The sympathetic nervous system and the metabolic syndrome. J Hypertens. 2007;25:909–920
- . Hypertension and associated metabolic abnormalities—the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996;334:374–381
- Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342:1378–1384
- Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med. 1997;157:1746–1752
- Sleep apnea and hypertension (A population-based study). Ann Intern Med. 1994;120:382–388
- . The kidney, hypertension, and obesity. Hypertension. 2003;41:625–633
- . Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy. Hypertension. 2004;43:518–524
- . Obesity hypertension. Am J Hypertens. 2002;15:50S–52S
- . Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance?. J Hum Hypertens. 2007;21:12–19
- . Obesity and hypertension: two epidemics or one?. Am J Physiol. 2004;286:R803–R813
- Obesity-associated hypertension: new insights into mechanisms. Hypertension. 2005;45:9–14
- . Spotlight on renin (The renin-angiotensin-aldosterone system and metabolic syndrome). J Renin Angiotensin Aldosterone Syst. 2006;7:184
- . Renin and aldosterone are higher and the hyperinsulinemic effect of salt restriction greater in subjects with risk factors clustering. Am J Hypertens. 1994;7:886–893
- Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension. 2006;48:239–245
- . Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension. 2000;35:1270–1277
- Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology. 2001;142:5220–5225
- Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension. J Hypertens. 2002;20:965–973
- Adipose tissue and circulating endothelial cell specific molecule-1 in human obesity. Horm Metab Res. 2006;38:28–33
- Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone. Circulation. 2005;111:1954–1961
- Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes. Diabetes Obes Metab. 2003;5:462–467
- Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation. J Hypertens. 2006;24:1809–1816
- . Mechanisms of disease: selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome. Nat Clin Pract Endocrinol Metab. 2005;1:92–99
- Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing’s syndrome. Eur J Endocrinol. 2006;155:435–441
- Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest. 1989;83:1168–1173
- . Effects of body fat distribution on regional lipolysis in obesity. J Clin Invest. 1991;88:609–613
- . Pressor effects of portal venous oleate infusion (A proposed mechanism for obesity hypertension). Hypertension. 1995;26:193–198
- Hemodynamic effects of lipids in humans. Am J Physiol. 2001;280:R1674–R1679
- Moderate sodium restriction enhances the pressor response to hyperlipidemia in obese, hypertensive patients. J Clin Hypertens. 2002;4:173–180
- . An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. Prostaglandins Leukot Essent Fatty Acids. 2002;67:163–167
- Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension. 2004;43:358–363
- Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A. 2003;100:14211–14216
- Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J Am Soc Nephrol. 2006;17:3438–3446
- . Resistant hypertension: prevalence and evolving concepts. J Clin Hypertens. 2007;9:2–6
- . Obesity-related cardiovascular disease: implications of obstructive sleep apnea. Diabetes Obes Metab. 2006;8:250–260
- Role for aldosterone in blood pressure regulation of obese adolescents. Am J Cardiol. 1986;57:613–618
- High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin Exp Pharmacol Physiol. 1994;21:315–318
- Potentially high prevalence of primary aldosteronism in a primary-care population. Lancet. 1999;353:40
- High prevalence of primary aldosteronism in the Tayside hypertension clinic population. J Hum Hypertens. 2000;14:311–315
- Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. J Clin Endocrinol Metab. 2000;85:1863–1867
- Primary aldosteronism and hypertensive disease. Hypertension. 2003;42:161–165
- Hyperaldosteronism among black and white subjects with resistant hypertension. Hypertension. 2002;40:892–896
- Screening for primary aldosteronism without discontinuing hypertensive medications: plasma aldosterone-renin ratio. Am J Kidney Dis. 2001;37:699–705
- Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J Clin Endocrinol Metab. 2006;91:454–459
- Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension. Chest. 2007;131:453–459
- High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J Hypertens. 2001;19:2271–2277
- Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea. Chest. 2004;125:112–117
- Aldosterone and refractory hypertension: a prospective cohort study. Am J Hypertens. 2006;19:373–380
- . Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens. 2003;16:925–930
- The role of spironolactone in the treatment of patients with refractory hypertension. Am J Hypertens. 2002;15:333–339
- Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade. Endocr J. 2004;51:243–251
- Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor. Cell Biochem Funct. 2002;20:237–245
- Aldosterone as a key mediator of the cardiometabolic syndrome in primary aldosteronism: an observational study. J Hypertens. 2007;25:177–186
- Impaired insulin action in primary hyperaldosteronism. Physiol Res. 2000;49:241–244
- Does the treatment of primary hyperaldosteronism influence glucose tolerance?. Physiol Res. 2003;52:503–506
- Can primary hyperaldosteronism be considered as a specific form of diabetes mellitus?. Physiol Res. 2001;50:603–607
- Insulin, renin-aldosterone system and blood pressure in obese people. Int J Obes Relat Metab Disord. 2001;25:239–242
- Relationships among plasma aldosterone, high-density lipoprotein cholesterol, and insulin in humans. Hypertension. 1995;25:30–36
- Association of adrenal steroids with hypertension and the metabolic syndrome in blacks. Hypertension. 2007;49:704–711
- Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment. Exp Clin Endocrinol Diabetes. 2000;108:21–25
- Mineralocorticoid receptor is involved in the regulation of genes responsible for hepatic glucose production. Biochem Biophys Res Commun. 2006;342:1291–1296
- . Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans. Prostaglandins Leukot Essent Fatty Acids. 1999;60:401–405
- Metabolic cardiovascular risk factors and the renin-aldosterone system in essential hypertension. J Hum Hypertens. 1992;6:27–29
- Effects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism. J Clin Endocrinol Metab. 1995;80:1816–1821
- Effects of a new hormone therapy, drospirenone and 17-beta-estradiol, in postmenopausal women with hypertension. Hypertension. 2006;48:246–253
- . Effects of 17beta-oestradiol plus different doses of drospirenone on adipose tissue, adiponectin and atherogenic metabolites in postmenopausal women. J Intern Med. 2005;258:544–553
- Changes in plasma lipids during renin-angiotensin system blockade by combination therapy (enalapril plus valsartan) in patients with diabetes and hypertension. J Cardiovasc Pharmacol. 2005;45:362–366
- Eplerenone inhibits atherosclerosis in nonhuman primates. Hypertension. 2005;46:1135–1139
- The effect of spironolactone on morbidity and mortality in patients with severe heart failure (Randomized Aldactone Evaluation Study Investigators). N Engl J Med. 1999;341:709–717
- Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol. 2005;46:425–431
- Metabolic syndrome and insulin resistance in the TROPHY sub-study: contrasting views in patients with high-normal blood pressure. Am J Hypertens. 2005;18:3–12
- −344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men. Am J Hypertens. 2007;20:218–222
- . Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension. 2004;43:41–47
- The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?. Int J Biochem Cell Biol. 2003;35:807–825
PII: S0270-9295(07)00094-0
doi: 10.1016/j.semnephrol.2007.07.009
© 2007 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 27, Issue 5
, Pages 529-537
, September 2007
