Seminars in Nephrology
Volume 27, Issue 6 , Pages 652-657, November 2007

Proteomic Analysis in Pediatric Renal Disease

  • Avram Z. Traum, MD

      Affiliations

    • Pediatric Nephrology Unit, Massachusetts General Hospital, Boston, MA.
    • Harvard Medical School, Boston, MA.
    • Corresponding Author InformationAddress reprint requests to Avram Traum, MD, Massachusetts General Hospital, Pediatric Nephrology Unit, 55 Fruit St, Yawkey 6C, Boston, MA 02114.
    • ,
  • Asher D. Schachter, MD, MMSc, MS

      Affiliations

    • Division of Nephrology, Children’s Hospital Boston, Children’s Hospital Informatics Program at Harvard-MIT Division of Health Sciences and Technology, Boston, MA.
    • Harvard Medical School, Boston, MA.

Summary 

Children with renal disease have tremendous potential for recovery, particularly when disease processes are detected early in the disease course. However, invasive diagnostic maneuvers can be challenging, especially in younger children who may require general anesthesia. Urine proteomics technologies present an opportunity to discover noninvasive yet informative diagnostic and prognostic markers of renal disease in children. In this article we review current concepts regarding the normal urine proteome, followed by an overview of urine proteomics as applied to nephrotic syndrome, and conclude with a discussion of some of the challenges of performing proteomic profiling on nephrotic urine, with its inherent abundance of proteins.

Keywords: Pediatrics, urine proteomics, noninvasive, biomarkers

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 Supported by a National Kidney Foundation of MA/RI/NH/VT Pediatric Renal Research Award (A.D.S., A.Z.T.) and a National Institutes of Health training grant T32 DK 007726 (A.Z.T.).

PII: S0270-9295(07)00127-1

doi:10.1016/j.semnephrol.2007.09.009

Seminars in Nephrology
Volume 27, Issue 6 , Pages 652-657, November 2007

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