Seminars in Nephrology
Volume 28, Issue 3 , Pages 227-244, May 2008

Dysregulation of Renal Aquaporins and Epithelial Sodium Channel in Lithium-Induced Nephrogenic Diabetes Insipidus

  • Jakob Nielsen, MD, PhD

      Affiliations

    • The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark.
    • ,
  • Tae-Hwan Kwon, MD, DMSc

      Affiliations

    • The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark.
    • Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu, Korea.
    • ,
  • Birgitte Mønster Christensen, PhD

      Affiliations

    • The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark.
    • ,
  • Jørgen Frøkiær, MD, DMSc

      Affiliations

    • The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark.
    • ,
  • Søren Nielsen, MD, DMSc

      Affiliations

    • The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Aarhus C, Denmark.
    • Corresponding Author InformationAddress reprint requests to Søren Nielsen, MD, DMSc, The Water and Salt Research Center, Institute of Anatomy, University of Aarhus, Wilhelm Meyers Alle, Building 1234, DK-8000 Aarhus C, Denmark.

Summary 

Lithium is used commonly to treat bipolar mood disorders. In addition to its primary therapeutic effects in the central nervous system lithium has a number of side effects in the kidney. The side effects include nephrogenic diabetes insipidus with polyuria, mild sodium wasting, and changes in acid/base balance. These functional changes are associated with marked structural changes in collecting duct cell composition and morphology, likely contributing to the functional changes. Over the past few years, investigations of lithium-induced renal changes have provided novel insight into the molecular mechanisms that are responsible for the disturbances in water, sodium, and acid/base metabolism. This includes dysregulation of renal aquaporins, epithelial sodium channel, and acid/base transporters. This review focuses on these issues with the aim to present this in context with clinically relevant features.

Keywords: AQP, ENaC, kidney, water balance

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 The Water and Salt Research Center at the University of Aarhus is established and supported by the Danish National Research Foundation (Danmarks Grundforskningsfond). This study was supported by The Danish Medical Research Council, the European Commission programs, Korea Science and Engineering Foundation grant funded by the Ministry of Science and Technology, Korea (R01-2007-000-20441-0).

PII: S0270-9295(08)00046-6

doi:10.1016/j.semnephrol.2008.03.002

Seminars in Nephrology
Volume 28, Issue 3 , Pages 227-244, May 2008

Article Tools

* Image Usage & Resolution