Viral Hemorrhagic Fever–Induced Acute Kidney Injury
Summary
Viral hemorrhagic fevers (VHFs) are diseases caused by the RNA virus from 4 different families (Flaviridiae, Arenaviridae, Bunyaviridae, and Filoviridae) that are acquired through the bite of an infected arthropod or by the inhalation of particles of rodent excreta. Among the VHFs, dengue and yellow fever are the most prevalent in tropical regions worldwide. The clinical presentation is characterized by fever, malaise, increased vascular permeability, and coagulation defects that can result in bleeding. Acute kidney injury is an uncommon complication but renal dysfunction has been associated with various VHFs. In this article we review the renal manifestations of dengue and yellow fever infections.
Keywords: Acute kidney injury, viral hemorrhagic fever, dengue, yellow fever
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Emerson Q. Lima was supported in part by a grant from Fundação de Amparo à Pesquisa do Estado de Säo Paulo (FAPESP), Brazil; and Mauricio L. Nogueira was supported by FAPESP and Conselho Nacional de Desenvolvimento Científico e Tecnológico grants.
PII: S0270-9295(08)00087-9
doi:10.1016/j.semnephrol.2008.04.009
© 2008 Elsevier Inc. All rights reserved.
