Seminars in Nephrology
Volume 28, Issue 5 , Pages 499-509, September 2008

Multiple Organ Dysfunction Syndrome in Children With Sepsis: Role of Genetic Factors

  • Orfeas Liangos, MD
    • ,
  • Bertrand L. Jaber, MD, MS

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Bertrand L. Jaber, MD, Department of Medicine, Division of Nephrology, Caritas St. Elizabeth's Medical Center, 736 Cambridge St, Boston, MA 02135

Division of Nephrology, Caritas St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, MA

Summary 

This review summarizes current knowledge on the impact of genetic markers on susceptibility, severity, and outcome of acute inflammatory disorders in children, with a special focus on systemic infections. A 14-year-old child with Neisseria meningitides bacteremia, complicated by septic shock and multiple organ dysfunction, is discussed as an exemplary case, and linked to the application of genetic epidemiology and the study of common disorders in children. The current pertinent literature is comprehensively reviewed and limitations and future directions are discussed.

Keywords: Genetic risk markers, sepsis, acute kidney injury, multiple organ, dysfunction syndrome

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 This work was supported by a grant from the National Institutes of Health (DK065102 to B.L.J.), and by a grant from the American Heart Association (0535367N to O.L.).

PII: S0270-9295(08)00119-8

doi:10.1016/j.semnephrol.2008.05.011

Seminars in Nephrology
Volume 28, Issue 5 , Pages 499-509, September 2008

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