Seminars in Nephrology
Volume 29, Issue 1 , Pages 30-38, January 2009

Do Low-Protein Diets Work in Chronic Kidney Disease Patients?

  • Denis Fouque, MD, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Denis Fouque, MD, PhD, Department of Nephrology, Hôpital Edouard HERRIOT, INSERM U870-University, Claude Bernard Lyon 1, 69437 Lyon Cedex 03, France
    • ,
  • Fitsum Guebre-Egziabher, MD

Department of Nephrology, Hôpital Edouard Herriot, INSERM U870-University, Lyon, France

Summary 

Patients with chronic kidney disease have been advised for many years to reduce their protein intake. This review addresses the biochemical, pathophysiologic, and nutritional background that underlies this recommendation. The clinical and therapeutic evidence for prescribing such diets is addressed, as well as the potential caveats. A proposed method for managing and monitoring patients also is provided.

Keywords: Low-protein diet, proteinuria, chronic kidney disease, clinical trial, meta-analysis

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PII: S0270-9295(08)00168-X

doi:10.1016/j.semnephrol.2008.10.005

Seminars in Nephrology
Volume 29, Issue 1 , Pages 30-38, January 2009

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