Seminars in Nephrology
Volume 29, Issue 3 , Pages 257-270 , May 2009

Hyponatremia in the Intensive Care Unit

  • Biff F. Palmer, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Biff F. Palmer, MD, Professor of Internal Medicine, Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390

References 

  1. Anderson RJ, Chung HM, Kluge R, Schrier RW. Hyponatremia: a prospective analysis of its epidemiology and the pathogenetic role of vasopressin. Ann Intern Med. 1985;102:164–168
  2. Gill G, Huda B, Boyd A, Skagen K, Wile D, Watson I, et al. Characteristics and mortality of severe hyponatraemia—a hospital-based study. Clin Endocrinol (Oxf). 2006;65:246–249
  3. Zilberberg MD, Exuzides A, Spalding J, Foreman A, Jones AG, Colby C, et al. Epidemiology, clinical and economic outcomes of admission hyponatremia among hospitalized patients. Curr Med Res Opin. 2008;24:1601–1608
  4. Palmer BF. Renal complications associated with use of nonsteroidal anti-inflammatory agents. J Investig Med. 1995;43:516–533
  5. Paut O, Lacroix F. Recent developments in the perioperative fluid management for the paediatric patient. Curr Opin Anaesthesiol. 2006;19:268–277
  6. Moritz M, Ayus J. Prevention of hospital-acquired hyponatremia: a case for using isotonic saline. Pediatrics. 2003;111:227–230
  7. Hoorn EJ, Geary D, Robb M, Halperin Ml, Bohn D. Acute hyponatremia related to intravenous fluid administration in hospitalized children: an observational study. Pediatrics. 2004;113:1279–1284
  8. Choong K, Kho ME, Menon K, Bohn D. Hypotonic versus isotonic saline in hospitalized children: a systematic review. Arch Dis Child. 2006;91:828–835
  9. Diederich S, Franzen NF, Bähr V, Oelkers W. Severe hyponatremia due to hypopituitarism with adrenal insufficiency: report on 28 cases. Eur J Endocrinol. 2003;148:609–617
  10. Oelkers W. Hyponatremia and inappropriate secretion of vasopressin (antidiuretic hormone) in patients with hypopituitarism. N Engl J Med. 1989;321:492–496
  11. Mandell IN, DeFronzo RA, Robertson GL, Forrest JN. Role of plasma arginine vasopressin in the impaired water diuresis of isolated glucocorticoid deficiency in the rat. Kidney Int. 1980;17:186–195
  12. Liu JP, Robinson PJ, Funder JW, Engler D. The biosynthesis and secretion of adrenocorticotropin by the ovine anterior pituitary is predominantly regulated by arginine vasopressin (AVP). J Biol Chem. 1990;265:14136–14142
  13. Sawchenko PE, Swanson LW, Vale WW. Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat. Proc Natl Acad Sci U S A. 1984;81:1883–1887
  14. Kiss JZ, Mezey E, Skirboll L. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy. Proc Natl Acad Sci U S A. 1984;81:1854–1858
  15. Davis LG, Arentzen R, Reid JM, et al. Glucocorticoid sensitivity of vasopressin mRNA levels in the paraventricular nucleus of the rat. Proc Natl Acad Sci U S A. 1986;83:1145–1149
  16. Green HH, Harrington AR, Valtin H. On the role of antidiuretic hormone in the inhibition of acute water diuresis in adrenal insufficiency and the effects of gluco- and mineralocorticoids in reversing the inhibition. J Clin Invest. 1970;49:1724
  17. Ishikawa SE, Schrier RW. Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats. Kidney Int. 1982;22:587–593
  18. Schrier R. Vasopressin and aquaporin 2 in clinical disorders of water homeostasis. Semin Nephrol. 2008;28:289–296
  19. Wartofsky L. Myxedema coma. Edocrinol Metab Clin N Am. 2006;35:687–698
  20. Warner MH, Holding S, Kilpatrick ES. The effect of newly diagnosed hypothyroidism on serum sodium concentrations: a retrospective study. Clin Endocrinol (Oxf). 2006;64:598–599
  21. Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O'Connor CM, et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J. 2007;28:920–921
  22. Schrier R, Bansal S. Pulmonary hypertension, right ventricular failure, and kidney: different from left ventricular failure. Clin J Am Soc Nephrol. 2008;3:1232–1237
  23. Forfia PR, Mathai SC, Fisher MR, Housten-Harris T, Hemnes AR, Champion HC, et al. Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2008;177:1364–1369
  24. Palmer BF. Pathogenesis of ascites and renal salt retention in cirrhosis. J Invest Med. 1999;47:183–202
  25. Angeli P, Wong F, Watson H, Ginès P CAPPS Investigators. Hyponatremia in cirrhosis: results of a patient population survey. Hepatology. 2006;44:1535–1542
  26. Heuman DM, Abou-Assi SG, Habib A, Williams LM, Stravits RT, Sanyal AJ, et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death. Hepatology. 2004;40:787–789
  27. Ruf AE, Kremers WK, Chavez LL, Descalzi VI, Podesta LG, Villamil FG. Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl. 2005;11:336–343
  28. Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH. Possible causes of central pontine myelinolysis after liver transplantation. World J Gastroenterol. 2004;10:2540–2543
  29. Browne WL, Nair B. The hyponatremic hypertensive syndrome in renal artery stenosis: an infrequent cause of hyponatremia. J Postgrad Med. 2007;53:41–43
  30. Agarwal M, Lynn K, Richards M, Nicholls M. Hyponatremic-hypertensive syndrome with renal ischemia: an underrecognized disorder. Hypertension. 1993;33:1020–1024
  31. Neeli S. Renal artery stenosis with hyponatremic hypertensive syndrome in a 7-year-old child. J Pediatr Urol. 2008;4:407–408
  32. Ashida A, Matsumura H, Inoue N, Katayama H, Kiyohara Y, Yamamoto T, et al. Two cases of hyponatremic-hypertensive syndrome in childhood with renovascular hypertension. Eur J Pediatr. 2006;165:336–339
  33. Nair V, Niederman MS, Masani N, Fishbane S. Hyponatremia in community-acquired pneumonia. Am J Nephrol. 2007;27:184–190
  34. Don M, Valerio G, Korppi M, Canciani M. Hyponatremia in pediatric community-acquired pneumonia. Pediatr Nephrol. 2008;10:1007
  35. Brouwer MC, van de Beek D, Heckenberg SGB, Spanjaard L, de Gans J. Hyponatermia in adults with community-acquire bacterial meningitis. QJM. 2007;100:37–40
  36. Moro N, Katayama Y, Igarashi T, Mori T, Kawamata T, Kojima J. Hyponatremia in patients with traumatic brain injury: incidence mechanism, and response to sodium supplementation or retention therapy with hydrocortisone. Surg Neurol. 2007;68:387–393
  37. Leaf A, Bartier F, Santos R, Wrong O. Evidence in man that urinary electrolyte loss induced by pitressin is a function of water retention. J Clin Invest. 1953;32:886–888
  38. Nelson PB, Seif SM, Maroon JC, Robinson AG. Hyponatremia in intracranial disease: perhaps not the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). J Neurosurg. 1981;55:938–941
  39. Nelson PB, Seif S, Gutai J, Robinson AG. Hyponatremia and natriuresis following subarachnoid hemorrhage in a monkey model. J Neurosurg. 1984;60:233–237
  40. Wijdicks EFM, Vermeulen M, ten Haaf JA, Hijdra A, Bakker WH, van Gijn J. Volume depletion and natriuresis in patients with a ruptured intracranial aneurysm. Ann Neurol. 1985;18:211–216
  41. Levine JP, Stelnicki E, Weiner H, McCarthy J. Hyponatremia in the postoperative craniofacial pediatric patient population: a connection to cerebral salt wasting syndrome and management of the disorder. Plast Reconstr Surg. 2001;108:1501–1508
  42. Sivakumar V, Rajshekhar V, Chandy MJ. Management of neurosurgical patients with hyponatremia and natriuresis. Neurosurgery. 1994;34:269–274
  43. Benito H, Iglesisas P, Guevara P, Fernandez-Reyes R. Hyponatremia secondary to cerebral salt-wasting syndrome associated to bacterial meningitis. Nefrologia. 2008;28:570–571
  44. Nagotkar L, Shanbag P, Dasarwar N. Cerebral salt wasting syndrome following neurosurgical intervention in tuberculous meningitis. Indian Pediatr. 2008;45:598–601
  45. Oster J, Perez G, Larios O, Bourgoignie J. Cerebral salt wasting in a man with carcinomatous meningitis. Arch Intern Med. 1983;143:2187–2188
  46. Singh S, Bohn D, Carlotti AP, et al. Cerebral salt wasting: truths, fallacies, theories, and challenges. Crit Care Med. 2002;30:2575
  47. Carlotti AP, Bohn D, Rutka JT, et al. A method to estimate urinary electrolyte excretion in patients at risk for developing cerebral salt wasting. J Neurosurg. 2001;95:420
  48. Palmer BF. Hyponatremia in patients with central nervous system disease: SIADH versus CSW. Trends Endocrinol Metab. 2003;14:182
  49. Sterns R, Silver S. Cerebral salt wasting versus SIADH: what difference?. J Am Soc Nephrol. 2008;19:194–196
  50. Sherlock M, O'Sullivan E, Agha A, et al. The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage. Clin Endocrinol (Oxf). 2006;64:250
  51. Lu D, Binder D, Chien B, Maisel A, Manley G. Cerebral salt wasting and elevated brain natriuretic peptide levels after traumatic brain injury: 2 case reports. Surg Neurol. 2008;69:226–229
  52. Berendes E, Walter M, Cullen P, et al. Secretion of brain natriuretic peptide in patients with aneurysmal subarachnoid hemorrhage. Lancet. 1997;349:245
  53. Wijdicks EF, Vermeulen M, Murray GD, et al. The effects of treating hypertension following aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg. 1990;92:111–117
  54. Papadimitriou DT, Spiteri A, Pagnier A, Bayle M, Mischalowski MD, Bourdat G, et al. Mineralocorticoid deficiency in post-operative cerebral salt wasting. J Pediatr Endocrinol Metab. 2007;20:1145–1150
  55. Taplin CE, Cowell CT, Silink M, Ambler GR. Fludrocortisone therapy in cerebral salt wasting. Pediatrics. 2006;118:1904–1908

PII: S0270-9295(09)00019-9

doi: 10.1016/j.semnephrol.2009.03.003

Seminars in Nephrology
Volume 29, Issue 3 , Pages 257-270 , May 2009