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Seminars in Nephrology
Volume 29, Issue 4
, Pages 321-337
, July 2009
Cell and Molecular Biology of Kidney Development
References
- . Early organogenesis of the kidney. Pediatr Nephrol. 1987;1:385–392
- . Pediatric nephrology. In: 3rd ed.. Baltimore: Williams & Wilkins; 1994;p. 3–24p. i
- . Interspecies chimeras: an experimental approach for studies on embryonic angiogenesis. Med Biol. 1985;63:43–65
- . Role of the VEGF—a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol. 2007;106:32–37
- Defects in enteric innervation and kidney development in mice lacking GDNF. Nature. 1996;382:73–76
- . Qualitative and quantitative morphology of renal nerves in C57BL/6J mice. Anat Rec. 2002;268:399–404
- . Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development. 2007;134:2533–2539
- Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol. 2008;317:83–94
- . Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development. Development. 1993;119:711–720
- . Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007;18:1121–1129
- Canonical WNT signaling during kidney development. Am J Physiol Renal Physiol. 2007;293:F494–F500
- . Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development. 2006;133:2995–3004
- . Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Gene Expr Patterns. 2006;6:826–834
- . Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008;324:88–98
- . The zebrafish pronephros: a genetic system for studies of kidney development. Pediatr Nephrol. 2000;14:428–435
- Odd-skipped genes encode repressors that control kidney development. Dev Biol. 2007;301:518–531
- . Odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development. 2008;135:3355–3367
- . Model systems for the study of kidney development: use of the pronephros in the analysis of organ induction and patterning. Dev Biol. 1997;188:189–204
- Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003;426:247–254
- Six1 is required for the early organogenesis of mammalian kidney. Development. 2003;130:3085–3094
- . A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol. 2007;27:7661–7668
- SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes. Proc Natl Acad Sci U S A. 2004;101:8090–8095
- . Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech Dev. 2007;124:290–303
- Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J Biol Chem. 2006;281:18918–18926
- Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development. 2001;128:3105–3115
- Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006;25:5214–5228
- Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008;3:169–181
- Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development. 2005;132:2809–2823
- . Laser capture-microarray analysis of Lim1 mutant kidney development. Genesis. 2007;45:432–439
- WT-1 is required for early kidney development. Cell. 1993;74:679–691
- . PAX8-mediated activation of the wt1 tumor suppressor gene. EMBO J. 1996;15:4297–4306
- Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development. 2005;132:5437–5449
- Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet. 1999;24:252–262
- Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J Am Soc Nephrol. 2006;17:2864–2870
- The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 2006;133:3005–3013
- Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development. 2005;132:529–539
- . Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol. 1999;10:2125–2134
- . VEGF spatially directs angiogenesis during metanephric development in vitro. Dev Biol. 2000;227:558–566
- c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol. 2006;299:238–249
- . Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev. 2002;16:1423–1432
- . Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol. 2008;319:396–405
- . Real-time analysis of ureteric bud branching morphogenesis in vitro. Dev Biol. 2004;271:98–108
- Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol. 2008;317:83–94
- Renal and neuronal abnormalities in mice lacking GDNF. Nature. 1996;382:76–79
- GDNF is required for kidney development and enteric innervation. Cold Spring Harb Symp Quant Biol. 1996;61:445–457
- Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996;382:70–73
- . Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A. 1996;93:10657–10661
- GDNF signalling through the Ret receptor tyrosine kinase. Nature. 1996;381:789–793
- . Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature. 1994;367:380–383
- . Regulation of c-ret expression by retinoic acid in rat metanephros: implication in nephron mass control. Am J Physiol. 1998;275:F938–F945
- Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase. Dev Biol. 2002;243:128–136
- . PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Dev Biol. 2007;307:290–299
- . The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells. J Cell Biol. 1998;142:1337–1345
- . Renal aplasia in humans is associated with RET mutations. Am J Hum Genet. 2008;82:344–351
- . RET receptor tyrosine kinase isoforms in kidney function and disease. Oncogene. 2002;21:5582–5592
- Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005;8:229–239
- . Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development. 2000;127:1387–1395
- SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004;6:709–717
- . Screening for mutations in BMP4 and FOXC1 genes in congenital anomalies of the kidney and urinary tract in humans. Tokai J Exp Clin Med. 2003;28:121–126
- ROBO2 gene variants are associated with familial vesicoureteral reflux. J Am Soc Nephrol. 2008;19:825–831
- . GDNF/Ret signaling and the development of the kidney. Bioessays. 2006;28:117–127
- . The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. Dev Cell. 2005;8:65–74
- . Overexpression of RET leads to vesicoureteric reflux in mice. Am J Physiol Renal Physiol. 2004;287:F1123–F1130
- . Semaphorin3a inhibits ureteric bud branching morphogenesis. Mech Dev. 2008;125:558–568
- Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat Genet. 2005;37:964–968
- . The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract. Curr Opin Pediatr. 2006;18:161–166
- Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999;146:255–264
- . Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. Dev Biol. 2001;231:31–46
- . Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994;372:679–683
- . Induction of kidney epithelial morphogenesis by cells expressing Wnt-1. Dev Biol. 1994;166:815–818
- PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem. 2006;281:12705–12712
- . Mesenchyme to epithelium transition during development of the mammalian kidney tubule. Acta Anat (Basel). 1996;156:187–201
- . Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev. 1998;12:1894–1906
- . Molecular regulation of kidney development: is the answer blowing in the Wnt?. Pediatr Nephrol. 2007;22:1825–1838
- . Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol. 2008;314:112–126
- Secreted Frizzled-related proteins can regulate metanephric development. Mech Dev. 2001;102:45–55
- . Control of murine kidney development by sonic hedgehog and its GLI effectors. Cell Cycle. 2006;5:1426–1430
- GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development. 2006;133:569–578
- . Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet. 2002;11:1129–1135
- . Murine models of VACTERL syndrome: role of sonic hedgehog signaling pathway. J Pediatr Surg. 2001;36:381–384
- . Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002;129(22):5301–5312
- . TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004;131:4593–4605
- Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004;131:3401–3410
- . BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Am J Physiol Renal Physiol. 2001;280:F19–F33
- BMP receptor ALK3 controls collecting system development. J Am Soc Nephrol. 2008;19:117–124
- Glypican-3 modulates inhibitory Bmp2-Smad signaling to control renal development in vivo. Mech Dev. 2005;122:928–938
- BMP4 substitutes for loss of BMP7 during kidney development. Dev Biol. 2005;286:637–646
- Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol. 2008;19:2181–2191
- Bmp in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol. 2008;19:685–694
- . Regulation of metanephric kidney development by growth/differentiation factor 11. Dev Biol. 2003;257:356–370
- . Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473–485
- Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development. 2007;134:2397–2405
- . Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition. J Cell Biol. 2001;155:845–858
- TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis. Development. 2001;128:1045–1057
- FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development. Dev Biol. 2006;297:103–117
- . Role of fibroblast growth factor receptor signaling in kidney development. Pediatr Nephrol. 2007;22:343–349
- FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005;132:3847–3857
- Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol. 2006;291:325–339
- Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res. 2008;64:592–598
- Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Development. 2004;131:3345–3356
- . Bradykinin B2 receptor null mice harboring a Ser23-to-Ala substitution in the p53 gene are protected from renal dysgenesis. Am J Physiol Renal Physiol. 2008;295:F1404–F1413
- . Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor. Cancer Res. 2006;66(5):2576–2583
- . Expression of a cut-related homeobox gene in developing and polycystic mouse kidney. Kidney Int. 1996;50:453–461
- . Mouse models of polycystic kidney disease. Curr Top Dev Biol. 2008;84:311–350
- . Roles of HNF-1beta in kidney development and congenital cystic diseases. Kidney Int. 2005;68:1944–1947
- VEGF receptor 2 blockade leads to renal cyst formation in mice. Kidney Int. 2006;69:1741–1748
- Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 2007;134:801–811
- . Repression of Pax-2 by WT1 during normal kidney development. Development. 1995;121:867–875
- . The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. J Am Soc Nephrol. 2004;15:3044–3051
- Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008;313:584–593
- . Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006;116(3):663–674
- Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008;135:3301–3310
- . A dual requirement for Iroquois genes during Xenopus kidney development. Development. 2008;135:3197–3207
- The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A. 2005;102:18473–18478
- The role of XTRAP-gamma in Xenopus pronephros development. Int J Dev Biol. 2005;49:401–408
Dr. Reidy was supported in part by National Institutes of Health grant T32 DK007110 30.
PII: S0270-9295(09)00046-1
doi: 10.1016/j.semnephrol.2009.03.009
© 2009 Elsevier Inc. All rights reserved.
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Seminars in Nephrology
Volume 29, Issue 4
, Pages 321-337
, July 2009
