Seminars in Nephrology
Volume 29, Issue 4 , Pages 360-369, July 2009

Renal Manifestations of Systemic Illness in Children

  • Keisha L. Gibson, MD, MPH

      Affiliations

    • UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
  • ,
  • Debbie S. Gipson, MD, MS

      Affiliations

    • UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
  • ,
  • Susan F. Massengill, MD

      Affiliations

    • Division of Pediatric Nephrology, Levine Children's Hospital at Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte, NC
    • Corresponding Author InformationAddress reprint requests to Susan F. Massengill, MD, Director, Division of Pediatric Nephrology, Levine Children's Hospital at Carolinas Medical Center, PO Box 32861, Charlotte, NC 28203

Summary 

Kidney disease may be associated with a systemic disorder or found in isolation. With advances in the understanding of the pathophysiology of glomerular disorders, the distinction between primary and secondary glomerular disease is no longer valid. A wide spectrum of glomerular, vascular, and tubulointerstitial diseases may accompany autoimmune disorders, nephritogenic pharmaceuticals, infections, or complement dysregulation. This article focuses on renal manifestations of systemic diseases such as vasculitis, drug- and infection-related tubulointerstitial injury, and thrombotic disorders.

Keywords: Vasculitis, nephritogenic, tubulointerstitial disease

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PII: S0270-9295(09)00049-7

doi:10.1016/j.semnephrol.2009.03.012

Seminars in Nephrology
Volume 29, Issue 4 , Pages 360-369, July 2009