Seminars in Nephrology
Volume 29, Issue 6 , Pages 587-593, November 2009

Podocytes and Glomerular Function with Aging

  • Jocelyn Wiggins, BM, BCh, MRCP

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Jocelyn E. Wiggins, BM, BCh, MRCP, Division of Geriatrics, Department of Internal Medicine, University of Michigan Health System, 1560 MSRBII, Box 5676, Ann Arbor, MI 48109-5676

Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI

Summary 

Kidney function declines with age in association with the development of age-associated glomerulosclerosis. The well-established structural and functional changes with age are reviewed briefly. The modification of aging pathology by calorie restriction is discussed. The role of the podocyte as a critical cell in the aging process is considered, using animal models and human biopsy material. Newer data on changes in gene expression and possible changes in biology in the glomerulus are discussed. There is speculation on the implications of this change in biology for human disease and progression.

Keywords: Aging, glomerulus, podocyte, calorie restriction

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 Supported by grants from the National Institutes of Health (KO8 AG022019, DK46073, and P50 DK39255), and by pilot grant AG08808 from the Claude Pepper Older Americans Independence Center. Funding also was received from the Geriatric Research, Educational and Clinical Center from the Veterans Administration; technical assistance was received from Ronald Koenig, MD, Director of the Michigan National Institute of Diabetes and Digestive and Kidney Disease Biotechnology Center (DK58771).

PII: S0270-9295(09)00147-8

doi:10.1016/j.semnephrol.2009.07.012

Seminars in Nephrology
Volume 29, Issue 6 , Pages 587-593, November 2009

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