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Diuretics: Introduction
My late father loved to tell the story of his first use of diuretics during his 1945 internship. Anxious to treat their dyspneic and edematous patient with a new mercurial diuretic, the house staff wa...
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Richard H. Sterns
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473-474
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Diuretics and Salt Transport Along the Nephron
Summary: The clinical use of diuretics almost uniformly predated the localization of their site of action. The consequence of diuretic specificity predicts clinical application and side effect, and th...
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Paul L. Bernstein,
David H. Ellison
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475-482
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Update in Diuretic Therapy: Clinical Pharmacology
Summary: All diuretics except spironolactone exert their effects from the lumen of the nephron. Thus, to exert an effect, they must reach the urine. Pharmacokinetics (PK) describes this access. Differ...
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D. Craig Brater
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483-494
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Diuretics in the Treatment of Hypertension
Summary: Diuretics are powerful agents that impair sodium reabsorption in renal tubules. Their ability to alter long-term sodium balance induces important hemodynamic changes that result in a reductio...
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Michael E. Ernst,
Samuel J. Mann
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495-502
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Use of Diuretics in Heart Failure and Cirrhosis
Summary: Sodium and water retention in cardiac failure and cirrhosis is pivotal in the morbidity and mortality of patients with these disorders. Moreover, the pathophysiology of these edematous disord...
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Robert W. Schrier
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503-512
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Intravenous High-Dose Furosemide and Hypertonic Saline Solutions for Refractory Heart Failure and Ascites
Summary: Several studies have shown the efficacy of hypertonic saline solution infusion in conditions in which regional organ blood flow is impaired. Our group has shown that treatment of patients wit...
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Antonino Tuttolomondo,
Antonio Pinto,
Gaspare Parrinello,
Giuseppe Licata
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513-522
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Diuretics in Acute Kidney Injury
Summary: Acute kidney injury (AKI) is common in hospitalized patients and is associated with significant morbidity and mortality. The incidence of AKI is increasing and despite clinical advances there...
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Sagar U. Nigwekar,
Sushrut S. Waikar
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523-534
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Diuretics and Disorders of Calcium Homeostasis
Summary: Diuretics commonly are administered in disorders of sodium balance. Loop diuretics inhibit the Na-K-2Cl transporter and also increase calcium excretion. They are often used in the treatment o...
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Marvin Grieff,
David A. Bushinsky
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535-541
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Metabolic Complications Associated With Use of Diuretics
Summary: Diuretics are commonly used therapeutic agents that act to inhibit sodium transport systems along the length of the renal tubule. The most effective diuretics are inhibitors of sodium chlorid...
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Biff F. Palmer
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542-552
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Diuretic-Associated Hyponatremia
Summary: Soon after their introduction in 1957, thiazide diuretics became a recognized cause of hyponatremia. Thiazides may be the sole cause and they may exacerbate hyponatremia in patients with diso...
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John K. Hix,
Stephen Silver,
Richard H. Sterns
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553-566
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Table of Contents
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Editorial Advisory Board
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A2
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