Advertisement
Research Article| Volume 11, ISSUE 3, P259-267, May 1991

Glomerular injury induced by antibody and complement

  • Richard J. Quigg
    Correspondence
    Address reprint requests to Richard J. Quigg, MD, Division of Nephrology, MCV Station Box 160, Richmond, VA 23298.
    Affiliations
    Division of Nephrology, Department of Internal Medicine, Medical College of Virginia, Richmond, VA, USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:027092959190044K
Glomerular injury induced by antibody and complement
Previous ArticleMechanisms of glomerular injury: An overview
Next ArticleThe role of the macrophage in glomerular injury
      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Seminars in Nephrology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Couser W.G.
        Mediation of immune glomerular injury.
        J Am Soc Nephrol. 1990; 1: 13-29
        • Davies D.R.
        • Metzger H.
        Structural basis of antibody function.
        Ann Rev Immunol. 1983; 1: 87-117
        • Couser W.G.
        • Salant D.J.
        In situ immune complex formation and glomerular injury.
        Kidney Int. 1980; 17: 1-13
        • Couser W.G.
        • Adler S.G.
        • Baker P.J.
        • et al.
        Mechanisms of immune complex formation and deposition in glomeruli.
        in: Robinson R.R. Proceedings of the IXth International Congress of Nephrology. Springer-Verlag, New York, NY1984: 508-539
        • Andres G.
        • Brentjens Jr.,
        • Caldwell P.R.B.
        • et al.
        Biology of disease. Formation of immune deposits and disease.
        Lab Invest. 1986; 55: 510-520
        • Wilson C.B.
        Antibody reactions with native or planted glomerular antigens producing nephritogenic immune deposits or selective cell injury.
        in: Wilson C.G. Brenner B.M. Stein J.H. Immunopathology of Renal Disease. Churchill Livingstone, New York, NY1988: 1-34
        • Tonegawa S.
        Somatic generation of antibody diversity.
        Nature. 1983; 302: 575-581
        • Yancopoulos G.D.
        • Alt F.W.
        Regulation of the assembly and expression of variable region genes.
        Ann Rev Immunol. 1986; 4: 338-368
        • Salant D.J.
        • Madaio M.P.
        • Adler S.
        • et al.
        Altered glomerular permeability induced by F(ab′)2 and Fab′ antibodies to rat renal tubular antigen.
        Kidney Int. 1981; 21: 36-43
        • Mendrick D.L.
        • Rennke H.G.
        I. Induction of proteinuria in the rat by a monoclonal antibody against SGP-115/107.
        Kidney Int. 1988; 33: 818-830
        • Orikasa M.
        • Matsui K.
        • Oite T.
        • Shimatzu F.
        Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody.
        J Immunol. 1988; 141: 807-814
        • Couser W.G.
        • Stilmant M.M.
        • Jermanovich N.B.
        Complement-independent nephrotoxic nephritis in the guinea pig.
        Kidney Int. 1977; 11: 170-180
        • Couser W.G.
        • Darby C.
        • Salant D.J.
        • et al.
        Anti-GBM antibody-induced proteinuria in isolated perfused rat kidney.
        Am J Physiol. 1985; 249: F241-F250
        • Couser W.G.
        • Baker P.J.
        • Adler S.
        Complement and the direct mediation of immune glomerular injury: A new perspective.
        Kidney Int. 1985; 28: 879-890
        • Ruddy S.
        Plasma protein effectors of inflammation: Complement.
        in: Textbook of Rheumatology. vol 3. Saunders, Philadelphia, PA1989: 241-252
        • Müller-Eberhard H.J.
        Introduction and overview.
        in: Müller-Eberhard H.J. Miescher P.A. Complement. Springer-Verlag, Berlin, Germany1985: 1-6
        • Lachmann P.J.
        • Hughes-Jones N.C.
        Initiation of complement activation.
        in: Müller-Eberhard H.J. Miescher P.A. Complement. Springer-Verlag, Berlin, Germany1985: 147-166
        • Ziccardi R.J.
        • Cooper N.R.
        Physicochemical and functional characterization of the Or subunit of the first complement component.
        J Immunol. 1976; 116: 496-503
        • Law S.K.
        • Levine R.P.
        Interaction between the third complement protein and cell surface macromolecules.
        in: Proc Natl Acad Sci USA. 74. 1980: 2701-2705
        • Müller-Eberhard H.J.
        The membrane attack complex.
        (Complement)in: Müller-Eberhard H.J. Miescher P.A. Complement. Springer-Verlag, Berlin, Germany1985: 227-275
        • Pangburn M.K.
        • Müller-Eberhard H.J.
        The alternative pathway of complement.
        in: Müller-Eberhard H.J. Miescher P.A. Complement. Springer-Verlag, Berlin, Germany1985: 185-214
        • Alper C.A.
        Inherited structural polymorphism in human C2: Evidence for genetic linkage between C2 and Bf.
        J Exp Med. 1976; 144: 1111-1115
        • Fearon D.T.
        • Wong W.W.
        Complement ligand-receptor interactions that mediate biological responses.
        Ann Rev Immunol. 1983; 1: 243-271
        • Egwang T.G.
        • Befus A.D.
        The role of complement in the induction and regulation of the immune responses.
        Immunol. 1984; 51: 207-224
        • Gee A.P.
        • Boyle M.D.P.
        • Borsos T.
        Distinction between C8-mediated and Math Eq mediated hemolysis on the basis of independent 86Rb and hemoglobin release.
        J Immunol. 1980; 124: 1905-1910
        • Stolfi R.L.
        Immune lytic transformation: A state of irreversible damage generated as a result of the reaction of the eighth component in the guinea pig complement system.
        J Immunol. 1968; 100: 46-54
        • Pangburn M.K.
        • Müller-Eberhard H.J.
        The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular protease.
        Biochem J. 1986; 235: 723-730
        • Fearon D.T.
        • Austen K.F.
        Properdin: Binding to Cab and stabilization of the C3b-dependent C3 convertase.
        J Exp Med. 1975; 142: 856-863
        • Vallota E.H.
        • Forristal J.
        • Spitzer R.E.
        • et al.
        Characteristics of a non-complement dependent C3-reactive complex formed from factors in nephritic and normal serum.
        J Exp Med. 1970; 131: 1306-1324
        • Daha M.R.
        • Fearon D.T.
        • Austen K.F.
        C3 nephritic factor: Stabilization of fluid phase and cell-bound alternative pathway convertase.
        J Immunol. 1976; 116: 1-7
        • Davis A.E.
        • Zeigler J.B.
        • Gelfand E.W.
        • et al.
        Heterogeneity of nephritic factor and its identification as an immunoglobulin.
        in: Proc Natl Acad Sci USA. 74. 1977: 3980-3983
        • Halbwachs L.
        • Leveille M.
        • Lesavere P.
        • et al.
        Nephritic factor of the classical pathway of complement. Immunoglobulin G autoantibody directed against the classical pathway C3 convertase enzyme.
        J Clin Invest. 1980; 65: 1249-1256
        • Shin M.L.
        • Gelfand M.C.
        • Nagle R.B.
        • et al.
        Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulas.
        J Immunol. 1977; 118: 869-873
        • Appay M.-D.
        • Kazatchkine M.D.
        • Levi-Strauss M.
        • et al.
        Expression of CR1 (CD35) mRNA in podocytes from adult and fetal human kidneys.
        Kidney Int. 1990; 38: 289-293
        • Quigg R.J.
        • Nicholson-Weller A.
        • Cybulsky A.V.
        • et al.
        Decay accelerating factor regulates complement activation on glomerular epithelial cells.
        J Immunol. 1989; 142: 877-882
        • Holers V.M.
        • Cole J.L.
        • Lublin D.M.
        • et al.
        Human C3band C4b-regulatory proteins: A new multi-gene family.
        Immunol Today. 1985; 6: 188-192
        • Cosio F.G.
        • Sedmak D.D.
        • Nahan J.D.
        • et al.
        Localization of decay accelerating factor in normal and diseased kidneys.
        Kidney Int. 1989; 36: 100-107
        • Shibata T.
        • Cosio F.G.
        • Nahman Jr., N.S.
        Complement (C′) activation by immune complexes (IC) causes mesangial cell (MC) to express decay accelerating factor (DAF).
        Kidney Int. 1990; 37 (abstr): 433
        • Schönermark M.
        • Hess S.
        • Berger B.
        • et al.
        Complement regulatory proteins in glomerular cells.
        Kidney Int. 1990; 37 (abstr): 431
        • Quigg R.J.
        Isolation of a novel complement regulatory protein (GCRP) from cultured rat glomerular epithelial cells (GEC).
        J Am Soc Nephrol. 1990; 1 (abstr): 535
        • Farquhar M.G.
        The glomerular basement membrane. A selective macromolecular filter.
        in: Hay E.D. Cell Biology of the Extracellular Matrix. Plenum Press, New York, NY1981: 335-378
        • Levy M.
        • Halbwachs-Mecarelli L.
        • Gubler M.-C.
        • et al.
        H deficiency in two brothers with atypical dense intramembranous deposit disease.
        Kidney Int. 1986; 30: 949-956
        • Quigg R.J.
        • Cybulsky A.V.
        • Badalamenti J.
        • Salant D.J.
        Anti-Fx1A inhibits decay of Math Eq convertases on the surface of glomerular epithelial cells.
        Kidney Int. 1988; 33 (abstr): 321
        • Halperin J.A.
        • Nicholson-Weller A.
        Paroxysmal nocturnal hemoglobinuria: A complement mediated disease.
        Complement Inflamm. 1989; 6: 65-72
        • Salant D.J.
        • Adler S.
        • Darby C.
        • et al.
        Influence of antigen distribution on the mediation of immunological glomerular injury.
        Kidney Int. 1985; 27: 938-950
        • Fries J.W.U.
        • Mendrick D.L.
        • Rennke H.G.
        Determinants of immune complex-mediated glomerulonephritis.
        Kidney Int. 1988; 34: 333-345
        • Brenner B.M.
        • Dworkin L.D.
        • Ichikawa I.
        Glomerular ultrafiltration.
        in: Brenner B.M. Rector Jr., F.C. The Kidney. Saunders, Philadelphia, PA1986: 124-144
        • Matsuo S.
        • Fukatsu A.
        • Taub M.L.
        • et al.
        Glomerulonephritis induced in the rabbit by anti-endothelial antibodies.
        J Clin Invest. 1987; 79: 1798-1811
        • Yamamoto T.
        • Wilson C.B.
        Complement dependence of antibody-induced mesangial cell damage in the rat.
        J Immunol. 1987; 138: 3758-3765
        • Johnson R.J.
        • Garcia R.L.
        • Pritzl P.
        • et al.
        Platelets mediate glomerular proliferation in immune complex nephritis induced by anti-mesangial cell antibodies in the rat.
        Am J Pathol. 1990; 136: 369-374
        • Makino H.
        • Gibbons J.T.
        • Reddy M.K.
        • et al.
        Nephritogenicity of antibodies to proteoglycans of the glomerular basement membrane—I.
        J Clin Invest. 1986; 77: 142-156
        • Miettinen A.
        • Stow J.L.
        • Mentone S.
        • et al.
        Antibodies to basement membrane heparan sulfate proteoglycans bind to the laminae rarae of the glomerular basement membrane (GBM) and induce subepithelial thickening.
        J Exp Med. 1986; 163: 1064-1084
        • Feintzeig I.D.
        • Abrahamson D.R.
        • Cybulsky A.V.
        • et al.
        Nephritogenic potential of sheep antibodies against glomerular basement membrane laminin in the rat.
        Lab Invest. 1986; 55: 531-541
        • Globus S.M.
        • Wilson C.B.
        Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall.
        Kidney Int. 1979; 16: 148-157
        • Johnson R.J.
        • Klebanoff A.J.
        • Ochi R.F.
        • et al.
        Participation of the myeloperoxidase-H2O2-halide system in immune complex nephritis.
        Kidney Int. 1987; 32: 342-349
        • Heymann W.
        • Hackel D.B.
        • Harwood S.
        • et al.
        Production of nephrotic syndrome in rats by Freund's adjuvant and rat kidney suspensions.
        in: Proc Soc Exp Biol Med. 100. 1959: 660-667
        • Feenstra K.
        • Lee R.V.D.
        • Greben H.A.
        • et al.
        Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: A histologic and immunohistologic study at the light microscopic and the ultrastructural level.
        Lab Invest. 1975; 32: 235-242
        • Salant D.J.
        • Darby C.
        • Couser W.G.
        Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals.
        J Clin Invest. 1980; 66: 71-81
        • Couser W.G.
        • Steinmuller D.R.
        • Stilmant M.M.
        • et al.
        Experimental glomerulonephritis in the isolated perfused rat kidney.
        J Clin Invest. 1978; 62: 1275-1287
        • Van Damme B.J.C.
        • Fleuren G.J.
        • Bakker W.W.
        • et al.
        Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens: V Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis.
        Lab Invest. 1978; 38: 502-510
        • Kerjaschki D.
        • Farquhar M.G.
        Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats.
        J Exp Med. 1983; 157: 667-686
        • Cybulsky A.V.
        • Quigg R.J.
        • Badalamenti J.
        • et al.
        Anti-Fx1A induces association of Heymann nephritis antigens with microfilaments of cultured glomerular visceral epithelial cells.
        Am J Pathol. 1987; 129: 373-384
        • Camussi G.
        • Brentjens J.R.
        • Noble B.
        • et al.
        Antibody-induced redistribution of Heymann antigen on the surface of cultured glomerular visceral epithelial cells: Possible role in the pathogenesis of Heymann glomerulonephritis.
        J Immunol. 1985; 135: 2409-2416
        • Kerjaschki D.
        • Miettinen A.
        • Farquhar M.G.
        Initial events in the formation of immune deposits in passive Heymann nephritis. Gp330-anti-gp330 immune complexes form in the epithelial coated pits and rapidly become attached to the glomerular basement membrane.
        J Exp Med. 1987; 187: 109-128
        • Brentjens J.R.
        • Andres G.
        Lesions of the kidney caused by the interaction of antibodies with antigens on the surface of renal cells.
        Kidney Int. 1989; 35: 954-968
        • Quigg R.J.
        • Abrahamson D.R.
        • Cybulsky A.V.
        • et al.
        Studies with antibodies to cultured rat glomerular epithelial cells. Subepithelial immune deposit formation after in vivo injection.
        Am J Pathol. 1989; 134: 1125-1133
        • Batsford S.R.
        • Takamiya H.
        • Vogt A.
        A model of in situ immune complex glomerulonephritis in the rat employing cationized ferritin.
        Clin Nephrol. 1980; 14: 211-216
        • Border W.A.
        • Ward H.J.
        • Kamil E.S.
        • et al.
        Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen.
        J Clin Invest. 1982; 69: 451-461
        • Oite T.
        • Batsford S.R.
        • Mihatsch M.J.
        • et al.
        Quantitative studies on in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen.
        J Exp Med. 1982; 155: 460-474
        • Gallo G.R.
        • Caulin-Glaser T.
        • Emancipator S.N.
        • et al.
        Nephritogenicity and differential distribution of glomerular immune complexes related to immunogen charge.
        Lab Invest. 1983; 48: 353-362
        • Salant D.J.
        • Belok S.
        • Madaio M.P.
        • et al.
        A new role for complement in experimental membranous nephropathy in rats.
        J Clin Invest. 1980; 66: 1339-1350
        • Groggel G.C.
        • Adler S.
        • Rennke H.G.
        • et al.
        Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit.
        J Clin Invest. 1983; 72: 1948-1957
        • Baker P.J.
        • Ochi R.F.
        • Shulze M.
        • et al.
        Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats.
        Am J Pathol. 1989; 135: 185-194
        • Cybulsky A.V.
        • Rennke H.G.
        • Feintzeig I.D.
        • Salant D.J.
        Complement-induced glomerular epithelial cell injury. Role of the membrane attack complex in rat membranous nephropathy.
        J Clin Invest. 1986; 77: 1096-1107
        • Cybulsky A.V.
        • Quigg R.J.
        • Salant D.J.
        The membrane attack complex in complement-mediated glomerular epithelial cell injury: Formation and stability of C5b-9 and C5b-7 in rat membranous nephropathy.
        J Immunol. 1986; 137: 1511-1516
        • Quigg R.J.
        • Cybulsky A.V.
        • Jacobs J.B.
        • et al.
        Anti-Fx1A produces complement-dependent cytotoxicity of glomerular epithelial cells.
        Kidney Int. 1988; 34: 43-52
        • Camussi G.
        • Salvidio G.
        • Biesecker G.
        • et al.
        Heymann antibodies induced complement-dependent injury of rat glomerular visceral epithelial cells.
        J Immunol. 1987; 139: 2906-2914
        • Cybulsky A.V.
        • Bonventre J.V.
        • Quigg R.J.
        • et al.
        Cytosolic calcium and protein kinase C reduce complement-mediated glomerular epithelial injury.
        Kidney Int. 1990; 38: 803-811
        • Kerjaschki D.
        • Shulze M.
        • Binder S.
        • et al.
        Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy.
        J Immunol. 1989; 143: 546-552
        • Shulze M.
        • Baker P.J.
        • Perkinson D.T.
        • et al.
        Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat.
        Kidney Int. 1989; 35: 60-68
        • Pruchno C.J.
        • Burns M.W.
        • Shulze M.
        • et al.
        Urinary excretion of C5b-9 reflects disease activity in passive Heymann nephritis.
        Kidney Int. 1989; 36: 65-71
        • Schulze M.
        • Baker P.J.
        • Johnson R.J.
        • et al.
        Urinary complement C5b-9 excretion in membranous nephropathy (MN).
        Kidney Int. 1988; 33 (abstr): 331
        • Salant D.J.
        • Quigg R.J.
        • Cybulsky A.V.
        Heymann nephritis: Mechanisms of renal injury.
        Kidney Int. 1989; 35: 976-984
        • Brenner B.M.
        hemodynamically mediated glomerular injury and the progressive nature of kidney disease.
        Kidney Int. 1983; 23: 647-655
        • Hänsch G.M.
        • Torbohm I.
        • Rother K.
        Chronic glomerulonephritis: Inflammatory mediators stimulate the collagen synthesis in glomerular epithelial cells.
        Int Arch Allergy Appl Immunol. 1989; 88: 139-143
        • Cybulsky A.V.
        • Salant D.J.
        • Quigg R.J.
        • et al.
        Complement C5b-9 complex activates phospholipases in glomerular epithelial cells.
        Am J Physiol. 1989; 257: F826-F836
        • Hänsch G.M.
        • Betz M.
        • Günther J.
        • et al.
        The complement membrane attack complex stimulates the prostanoid production of cultured glomerular epithelial cells.
        Int Arch Allergy Appl Immunol. 1988; 85: 87-93
        • Collaborative Study of the Adult Idiopathic Nephrotic Syndrome
        A controlled study of short-term prednisone treatment in adults with membranous nephropathy.
        N Engl J Med. 1979; 301: 1301-1306
        • Ponticelli C.
        • Zucchelli P.
        • Passerini P.
        • et al.
        A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy.
        N Engl J Med. 1989; 320: 8-13
        • Strom T.B.
        • Kelley V.E.
        Toward more selective therapies to block undesired immune responses.
        Kidney Int. 1989; 35: 1026-1033

      Article info

      Footnotes

      ☆Supported by NIH FIRST Award DK 41873.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:027092959190044K

      Copyright

      © 1991 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX