Summary
The tools available to physicians for the treatment of hyponatremia, the most common
of electrolyte disorders, are limited by lack of effectiveness, compliance difficulties,
and toxicity problems. For this reason the development of novel oral antagonists of
vasopressin provide a new approach to the management of these disorders. Since vasopressin
plays a central role in the pathogenesis of most hyponatremic disorders, the inhibition
of binding of the hormone to its receptors is likely to provide a most reliable and
reproducible response leading to increases in free water excretion. This article reviews
many of the studies that have been undertaken with this new class of agents, both
in hypovolemic and hypervolemic settings.
Keywords
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© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
