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High Risk of ESRD in Type 1 Diabetes: Call for Action: Introduction

      Despite 30 years of significant improvements in the care of patients with type 1 diabetes (T1D), the risk of end-stage renal disease (ESRD) in these patients in the United States has increased rather than decreased, although it now occurs at slightly older ages. Furthermore, the competing risk of mortality from other causes (including cardiovascular disease) for patients with diabetic nephropathy has proved to be a relatively minor competitor. Therefore, ESRD has become the major contributor to the excess morbidity and premature mortality of patients with T1D. This state of affairs is a call to action and the rationale for this special issue of Seminars in Nephrology.
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