Summary
Mounting evidence from human, animal, and in vitro studies indicates that existing
drugs, developed to treat other disorders, also might be effective in preventing or
slowing the progression of diabetic nephropathy to end-stage renal disease. Examples
of such drugs include the urate-lowering agent allopurinol, the anti–tumor necrosis
factor agents etanercept and infliximab, and the immunomodulating drug abatacept.
Because some of these medications are already on the market and have been used for
a number of years for other indications, they can be tested immediately in human beings
for a beneficial effect on renal function in diabetes. Special emphasis should be
placed on evaluating the use of these drugs early in the course of diabetic nephropathy
when renal damage is most likely to be reversible and interventions can yield the
greatest delay to end-stage renal disease.
Keywords
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Article info
Footnotes
Financial support: Supported in part by National Institutes of Health grant R03 DK094484 (A.D.), Italian Ministry of Education, University, and Research grant “Staminali” RF-FSR-2008-1213704, a Juvenile Diabetes Research Foundation Career Development Award, and an American Society of Nephrology Career Development Award (P.F.), and American Diabetes Association mentor-based fellowship 7-03-MN-28 and a Pilot & Feasibility grant funded by National Institutes of Health grant P30 DK36836 to the Diabetes Research Center (DRC) at the Joslin Diabetes Center (M.A.N).
Conflict of interest statement: none.
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