Summary
Diabetic nephropathy is the single major cause of kidney failure in the industrialized
world and given the emerging global pandemic of diabetes mellitus, its prevalence
is expected to only increase. Because of the lack of dynamic biomarkers that define
the rate of kidney function loss, there are few proof-of-concept clinical trials for
new therapeutics to treat diabetic nephropathy. A molecular understanding of the pathogenesis
of diabetic nephropathy also is lacking. These deficiencies are magnified by the fact
that most mouse models of diabetic nephropathy fail to show progressive kidney disease.
Recently, some mouse models that showed requisite phenotypic changes of diabetic nephropathy
have been identified. Validation of results obtained in these experimental models,
and showing whether they accurately can predict clinical response to therapeutics
in human diabetic nephropathy, must now be established.
Keywords
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Financial disclosure and conflict of interest statements: none.
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© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
