Summary
Regenerative medicine strategies using induced pluripotent stem (iPS) cells are among
the candidate approaches to treat diabetic nephropathy caused by type 1 diabetes.
Cell transplantation therapy and disease modeling with patient-derived iPS cells should
be examined for diabetic renal disease. Considerable work already has been performed
with regard to the generation of renal lineage cells from mouse embryonic stem cells,
however, few reports have described research with human embryonic stem cells or iPS
cells. Further elucidation of the mechanisms of kidney development and establishing
the method for directed differentiation from human iPS cells into renal lineage cells
will be required for the development of iPS cell technology–based treatment for diabetic
nephropathy.
Keywords
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Financial disclosure and conflict of interest statements: none.
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© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
