Summary
Acid-base balance and potassium disorders are often clinically linked. Importantly,
acid-base disorders alter potassium transport. In general, acidosis causes decreased
K+ secretion and increased reabsorption in the collecting duct. Alkalosis has the opposite
effects, often leading to hypokalemia. Potassium disorders also influence acid-base
homeostasis. Potassium depletion causes increased H+ secretion, ammoniagenesis and H-K-ATPase activity. Hyperkalemia decreases ammoniagenesis
and NH4+ transport in the thick ascending limb. Some combined potassium and acid-base disorders
involve indirect factors such as aldosterone, impaired renal function, volume depletion,
and diarrhea. In summary, disorders of potassium and acid-base homeostasis are mechanistically
linked and clinically important.
Keywords
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☆Financial disclosure and conflict of interest statements: none.
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