The burden of acute kidney injury (AKI) and chronic kidney disease (CKD) increases
as much as hardly any other malady apart from obesity in the United States and pulmonary
disorders in China. But in contrast to these two mentioned, the increase in AKI and
CKD happens globally as we breathe. Nephrologists are well aware of the tremendous
clinical need to define novel concepts, hypotheses, therapeutic targets, drugs, and
cures, but instead abandon these developments to their fate instead of translating
basic scientific concepts. Given the awareness of the medical disaster of ever-increasing
numbers of dialysis treatments and exploding costs for AKI/CKD, it is disappointing
to realize the number of approaches to develop novel first-in-class compounds, many
of which do not have a ghost of a chance for success. Trials that combine the next
best immunosuppressants have failed multiple times and did not change the game. It
is time for something new.
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Footnotes
Financial support: The Linkermann group is funded by the German research foundation in the Cluster of Excellence, Inflammation at interfaces (EXC 306), and the research is supported by Genentech, Glaxo Smith Kline, and Apogenix (material transfer agreements).
☆☆Conflict of interest statement: The author has received research grants from Pfizer, Novartis, Fresenius Medical Care, and the Else Kröner-Fresenius Stiftung, and honoraria and/or travel grants from Astellas, Otsuka, Genentech, Alexion, and Tekmira.
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© 2016 Elsevier Inc. All rights reserved.
