The Chronic Kidney Disease in Children (CKiD) cohort study, initiated in 2003, was
designed to fill critical gaps in our knowledge of kidney disease in children. The
primary aims of the study since its inception have been as follows: (1) to identify
novel risk factors for chronic kidney disease (CKD) progression; (2) to measure the
impact of kidney function decrease on growth, cognition, and behavior; and (3) to
characterize the evolution of cardiovascular disease risk factors. The CKiD study
is a large observational cohort study of children with kidney diseases and is a network
spanning 56 sites in the United States and Canada. As of this writing, the CKiD study
has recruited 1095 children with CKD over three recruitment waves to target complementary
features of the life-course of pediatric CKD. The CKiD study has generated landmark
studies in glomerular filtration rate (GFR) estimation, identified risk factors for
CKD progression, the epidemiology of kidney replacement therapy, clinical prediction
models for risk stratification, and the impact of CKD on cardiovascular disease, neurodevelopment,
and growth.
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Financial disclosure and conflict of interest statements: none.
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