Summary: Transplant professionals strive to improve domestic kidney transplantation rates
safely, cost efficiently, and ethically, but to increase rates further may wish to
allow their recipients and donors to traverse international boundaries. Travel for
transplantation presents significant challenges to the practice of transplantation
medicine and donor medicine, but can be enhanced if sustainable international registries
develop to include low- and low-middle income countries. Robust data collection and
sharing across registries, linking pretransplant information to post-transplant information,
linking donor to recipient information, increasing living donor transplant activity
through paired exchange, and ongoing reporting of results to permit flexibility and
adaptability to changing clinical environments, will all serve to enhance kidney transplantation
across international boundaries.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Seminars in NephrologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
REFERENCES
- Worldwide access to treatment for end-stage kidney disease: a systematic review.Lancet. 2015; 385: 1975-1982https://doi.org/10.1016/S0140-6736(14)61601-9
- Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant.N Engl J Med. 1999; 341: 1725-1730https://doi.org/10.1056/NEJM199912023412303
- Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes.Am J Transplant. 2011; 11: 2093-2109https://doi.org/10.1111/j.1600-6143.2011.03686.x
- global estimates of capacity for kidney transplantation in world countries and regions.Transplantation. 2022; 106: 1113-1122https://doi.org/10.1097/TP.0000000000003943
- Outcome measures framework: information model report: registry of patient registries [internet].Agency for Healthcare Research and Quality (US), 2018 (Accessed January 2, 2022.)
- Severe Chronic Neutropenia International Registry. Registries for study of nonmalignant hematological diseases: the example of the Severe Chronic Neutropenia International Registry.Curr Opin Hematol. 2020; 27: 18-26https://doi.org/10.1097/MOH.0000000000000558
- Registering a need.BMJ. 1992; 305: 597-598https://doi.org/10.1136/bmj.305.6854.597
- Review article: use of renal registry data for research, health-care planning and quality improvement: what can we learn from registry data in the Asia-Pacific region?.Nephrology (Carlton). 2008; 13: 745-752https://doi.org/10.1111/j.1440-1797.2008.01044.x
- Evaluation and implementation of public health registries.Public Health Rep. 1991; 106: 142-150
- Gliklich RE Dreyer NA Leavy MB Registries for Evaluating Patient Outcomes: A User’s Guide [Internet]. 3rd ed. Agency for Healthcare Research and Quality (US), 2014 (Accessed January 2, 2022.)
- Renal registry in Hong Kong-the first 20 years.Kidney Int Suppl. 2015; 5 (2011): 33-38https://doi.org/10.1038/kisup.2015.7
- Australian registries-ANZDATA and ANZOD.Transplant Rev (Orlando). 2013; 27: 46-49https://doi.org/10.1016/j.trre.2013.01.003
National Institute of Neurological Disorders and Stroke. Common Data Elements. Accessed January 2, 2022. https://www.commondataelements.ninds.nih.gov/#page=Default.
- A framework for creating standardized outcome measures for patient registries.J Comp Eff Res. 2014; 3: 473-480https://doi.org/10.2217/cer.14.38
- Kidney transplant registries: how to optimise their utility?.Nefrologia (Engl Ed). 2019; 39: 581-591https://doi.org/10.1016/j.nefro.2018.11.008
- DEBATE-statistical analysis plans for observational studies.BMC Med Res Methodol. 2019; 19: 233https://doi.org/10.1186/s12874-019-0879-5
- Leitlinien für Forschungsberichte sind auch für Leser medizinischer Fachartikel hilfreich: CONSORT, STARD, STROBE & Co [Reporting guidelines are also useful for readers of medical research publications: CONSORT, STARD, STROBE and others].Dtsch Med Wochenschr. 2009; 134: 2078-2083https://doi.org/10.1055/s-0029-1237560
- Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.JAMA. 2000; 283: 2008-2012https://doi.org/10.1001/jama.283.15.2008
- Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement.BMC Med. 2015; 13: 1https://doi.org/10.1186/s12916-014-0241-z
- Actual causes of death in the United States, 2000.JAMA. 2004; 291 (Erratum in: JAMA. 2005;293(3):298. Erratum in: JAMA. 2005;293(3):293-294.): 1238-1245https://doi.org/10.1001/jama.291.10.1238
- The association of community health indicators with outcomes for kidney transplant recipients in the United States.Arch Surg. 2012; 147: 520-526https://doi.org/10.1001/archsurg.2011.2220
- Kidney transplant recipients with rheumatic diseases: epidemiological data from the Polish Transplant Registries 1998-2015.Transplant Proc. 2018; 50: 1654-1657https://doi.org/10.1016/j.transproceed.2018.03.122
- The overlapping risk profile between dialysis patients listed and not listed for renal transplantation.Am J Transplant. 2008; 8: 58-68https://doi.org/10.1111/j.1600-6143.2007.02020.x
- Wait expectations: the impact of delisting as an outcome from the kidney transplant waitlist.Clin Transplant. 2021; 35: e14250https://doi.org/10.1111/ctr.14250
- Mortality on a renal transplantation waiting list.Nefrologia. 2015; 35: 18-27https://doi.org/10.3265/Nefrologia.pre2014.Oct.12681
- National and international kidney failure registries: characteristics, commonalities, and contrasts.Kidney Int. 2022; 101: 23-35https://doi.org/10.1016/j.kint.2021.09.024
- Patient and center characteristics associated with kidney transplant outcomes: a binational registry analysis.Transpl Int. 2020; 33: 1667-1680https://doi.org/10.1111/tri.13681
- Risk-factor profile of living kidney donors: the Australia and New Zealand Dialysis and Transplant Living Kidney Donor Registry 2004-2012.Transplantation. 2016; 100: 1278-1283https://doi.org/10.1097/TP.0000000000000877
- Australian and New Zealand Paediatric Nephrology Association. Long-term survival of children with end-stage renal disease.N Engl J Med. 2004; 350: 2654-2662https://doi.org/10.1056/NEJMoa031643
- Survival in living kidney donors: an Australian and New Zealand Cohort Study Using Data Linkage.Transplant Direct. 2020; 6: e533https://doi.org/10.1097/TXD.0000000000000975
- Cancer incidence before and after kidney transplantation.JAMA. 2006; 296: 2823-2831https://doi.org/10.1001/jama.296.23.2823
- Steroids and recurrent IgA nephropathy after kidney transplantation.Am J Transplant. 2011; 11: 1645-1649https://doi.org/10.1111/j.1600-6143.2011.03667.x
- Recurrent glomerulonephritis after kidney transplantation: risk factors and allograft outcomes.Kidney Int. 2017; 92: 461-469https://doi.org/10.1016/j.kint.2017.03.015
- When and how should multiple imputation be used for handling missing data in randomised clinical trials - a practical guide with flowcharts.BMC Med Res Methodol. 2017; 17: 162https://doi.org/10.1186/s12874-017-0442-1
- How great is the survival advantage of transplantation over dialysis in elderly patients?.Nephrol Dial Transplant. 2004; 19: 945-951https://doi.org/10.1093/ndt/gfh022
- Daily hemodialysis practices in Australia/New Zealand and in France: a comparative cohort study.BMC Nephrol. 2019; 20: 156https://doi.org/10.1186/s12882-019-1330-1
- Mortality after kidney transplantation: a comparison between the United States and Canada.Am J Transplant. 2006; 6: 109-114https://doi.org/10.1111/j.1600-6143.2005.01141.x
- Consolidated criteria for strengthening reporting of health research involving indigenous peoples: the CONSIDER statement.BMC Med Res Methodol. 2019; 19: 173https://doi.org/10.1186/s12874-019-0815-8
- Ethics of healthcare research in developing countries.J R Soc Med. 2002; 95: 275-276https://doi.org/10.1258/jrsm.95.6.275
- Quality and safety in health care, part XXXIV: the PINNACLE Registry.Clin Nucl Med. 2018; 43: 246-247https://doi.org/10.1097/RLU.0000000000001884
- Application description and policy model in collaborative environment for sharing of information on epidemiological and clinical research data sets.PLoS One. 2010; 5: e9314https://doi.org/10.1371/journal.pone.0009314
- Living donor renal transplantation: recent developments and perspectives.Nat Clin Pract Nephrol. 2007; 3: 31-41https://doi.org/10.1038/ncpneph0383
- OPTN/SRTR 2019 annual data report: kidney.Am J Transplant. 2021; 21: 21-137https://doi.org/10.1111/ajt.16502
- Long-term risks for kidney donors.Kidney Int. 2014; 86: 162-167https://doi.org/10.1038/ki.2013.460
- Risk of end-stage renal disease following live kidney donation.JAMA. 2014; 311: 579-586https://doi.org/10.1001/jama.2013.285141
- Long-term consequences of kidney donation.N Engl J Med. 2009; 360: 459-469https://doi.org/10.1056/NEJMoa0804883
- Risks of living kidney donation: current state of knowledge on outcomes important to donors.Clin J Am Soc Nephrol. 2019; 14: 597-608https://doi.org/10.2215/CJN.11220918
- Living Donor Collective Participants. The Living Donor Collective: a scientific registry for living donors.Am J Transplant. 2017; 17: 3040-3048https://doi.org/10.1111/ajt.14365
- Post-transplant outcomes in recipients of living donor kidneys and intended recipients of living donor kidneys.BMC Nephrol. 2022; 23: 97https://doi.org/10.1186/s12882-022-02718-6
- Outcomes of living kidney donor candidate evaluations in the Living Donor Collective Pilot Registry.Transplant Direct. 2021; 7: e689https://doi.org/10.1097/TXD.0000000000001143
- Best practices to optimize utilization of the National Living Donor Assistance Center for the financial assistance of living organ donors.Am J Transplant. 2020; 20: 25-33https://doi.org/10.1111/ajt.15684
- Understanding the sex disparity in living kidney donation.J Eval Clin Pract. 2018; 24: 999-1004https://doi.org/10.1111/jep.13015
- Has the UK living kidney donor population changed over time? A cross-sectional descriptive analysis of the UK living donor registry between 2006 and 2017.BMJ Open. 2020; 10e033906https://doi.org/10.1136/bmjopen-2019-033906
- Temporal trends in living kidney donation in France between 2007 and 2017.Nephrol Dial Transplant. 2021; 36: 730-738https://doi.org/10.1093/ndt/gfz229
- Identifying outcomes that are important to living kidney donors: a nominal group technique study.Clin J Am Soc Nephrol. 2018; 13: 916-926https://doi.org/10.2215/CJN.13441217
NHS Blood and Transplant, Annual Report on Living Donor Kidney Transplantation 2020/21, 2022. Accessed August 3, 2022. https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/25370/annual-report-on-living-donor-kidney-transplantation-2020-21.pdf.
- Living-donor follow-up attitudes and practices in U.S. kidney and liver donor programs.Transplantation. 2013; 95: 883-888https://doi.org/10.1097/TP.0b013e31828279fd
- The national landscape of living kidney donor follow-up in the United States.Am J Transplant. 2017; 17: 3131-3140https://doi.org/10.1111/ajt.14356
- The impact of the General Data Protection Regulation on health research.Br Med Bull. 2018; 128: 109-118https://doi.org/10.1093/bmb/ldy038
Organisation for Economic Cooperation and Development. A road map for a country-led data revolution, 2015. Accessed: September 2, 2021. https://read.oecd-ilibrary.org/development/a-road-map-for-a-country-led-data-revolution_9789264234703-en#page1.
- Data challenges in addressing chronic kidney disease in low- and lower-middle-income countries.Kidney Int Rep. 2021; 6: 1503-1512https://doi.org/10.1016/j.ekir.2021.03.901
- International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in South Asia.Kidney Int Suppl. 2021; 11 (2011): e97-e105https://doi.org/10.1016/j.kisu.2021.01.006
- A renal registry for Africa: first steps.Clin Kidney J. 2016; 9: 162-167https://doi.org/10.1093/ckj/sfv122
- Economic evaluation of clinical quality registries: final report.ACSQHC, 2016 (Accessed February 1, 2022)
- Continuous quality improvement initiatives to sustainably reduce peritoneal dialysis-related infections in Australia and New Zealand.Perit Dial Int. 2016; 36: 472-477https://doi.org/10.3747/pdi.2016.00114
- Countries need better information to receive development aid.Bull World Health Organ. 2005; 83 (Accessed September 2, 2021.): 565-566
- Partnership in Statistics for Development in the 21st Century (PARIS21).Secretary General's Report to Ministers 2019. OECD Publishing, 2019https://doi.org/10.1787/078f091a-en
- National quality registries: how to improve the quality of data?.J Thorac Dis. 2018; 10: S3490-S3499https://doi.org/10.21037/jtd.2018.04.146
World Health Organization global strategy on digital health. World Health Organization (2020-2025). Accessed February 16, 2021.https://cdn.who.int/media/docs/default-source/documents/gs4dhdaa2a9f352b0445bafbc79ca799dce4d_02adc66d-800b-4eb5-82d4-f0bc778a5a2c.pdf?sfvrsn=f112ede5_68.
- Strategic Plan Working Groups. Strategic plan for integrated care of patients with kidney failure.Kidney Int. 2020; 98: S117-S134https://doi.org/10.1016/j.kint.2020.07.023
- Capturing and monitoring global differences in untreated and treated end-stage kidney disease, kidney replacement therapy modality, and outcomes.Kidney Int Suppl. (2011). 2020; 10: e3-e9https://doi.org/10.1016/j.kisu.2019.11.001
- The declaration of Istanbul on organ trafficking and transplant tourism.Clin J Am Soc Nephrol. 2008; 3: 1227-1231https://doi.org/10.2215/CJN.03320708
- Outcomes of commercial renal transplantation: a Canadian experience.Transplantation. 2006; 82: 1130-1135https://doi.org/10.1097/01.tp.0000241072.03400.11
- Commercial kidney transplantation is an important risk factor in long-term kidney allograft survival.Kidney Int. 2016; 89: 1119-1124https://doi.org/10.1016/j.kint.2015.12.047
- The landscape of international living kidney donation in the United States.Am J Transplant. 2019; 19: 2009-2019https://doi.org/10.1111/ajt.15256
- Care of international living kidney donor candidates in the United States: a survey of contemporary experience, practice, and challenges.Clin Transplant. 2020; 34: e14064https://doi.org/10.1111/ctr.14064
- How to increase kidney transplant activity throughout Europe–an advocacy review by the European Kidney Health Alliance.Nephrol Dial Transplant. 2019; 34: 1254-1261https://doi.org/10.1093/ndt/gfy390
- Indigenous people in Australia, Canada, New Zealand and the United States are less likely to receive renal transplantation.Kidney Int. 2009; 76: 659-664https://doi.org/10.1038/ki.2009.236
- The International Society for Heart and Lung Transplantation Registries in the era of big data with global reach.J Heart Lung Transplant. 2015; 34: 1225-1232https://doi.org/10.1016/j.healun.2015.08.001
- Kidney paired donation and the “valuable consideration” problem: the experiences of Australia, Canada, and the United States.Transplantation. 2017; 101: 1996-2002https://doi.org/10.1097/TP.0000000000001778
- Domino paired kidney donation: a strategy to make best use of live non-directed donation.Lancet. 2006; 368: 419-421https://doi.org/10.1016/S0140-6736(06)69115-0
- Distinguishing internal property from external property in kidney transplantation.J Eval Clin Pract. 2016; 22: 539-543https://doi.org/10.1111/jep.12571
- Complete chain of the first global kidney exchange transplant and 3-yr follow-up.Eur Urol Focus. 2018; 4: 190-197https://doi.org/10.1016/j.euf.2018.07.021
- A moral dilemma argument against clinical trials of incentives for kidney donation.Transplant Res. 2015; 4: 3https://doi.org/10.1186/s13737-015-0025-9
- COVID-19-associated mortality among kidney transplant recipients and candidates in the United States.Clin J Am Soc Nephrol. 2021; 16: 1695-1703https://doi.org/10.2215/CJN.02690221
- Mortality risk factors of COVID-19 infection in kidney transplantation recipients: a systematic review and meta-analysis of cohorts and clinical registries.Sci Rep. 2021; 11: 20073https://doi.org/10.1038/s41598-021-99713-y
- Is COVID-19 infection more severe in kidney transplant recipients?.Am J Transplant. 2021; 21: 1295-1303https://doi.org/10.1111/ajt.16424
Article info
Publication history
Published online: January 04, 2023
Publication stage
In Press Corrected ProofFootnotes
Financial disclosure and conflict of interest statements: none.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
